Clinical trials: Neuromuscular Block
ARDS
Paediatric Ards Neuromuscular Blockade Study
Paediatric acute respiratory distress syndrome (ARDS) is a manifestation of severe, life-threatening lung injury. Care for paediatric patient is mainly supportive and based on what works in adults and personal experiences…
- Trial name
- PAN (NCT02902055)
- Testing
- Neuromuscular Blocking Agents, Isotonic saline
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- University Medical Center Groningen
Intubation
Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Emergency intubation of patients in intensive care is a high-risk endeavour. For many decades, succinylcholine has been the neuromuscular blocking agent of choice.
- Trial name
- NCT00355368
- Testing
- Succinylcholine, Rocuronium
- Where
- Switzerland
- Volunteers
- 420 people
- Sponsor
- University Hospital, Basel, Switzerland
Neuromuscular Blockade, Neuromuscular Blockade, Residual
Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade
The aim of the present study will be to evaluate by means of a prospective randomized clinical trial, the time required for the reversal of moderate neuromuscular blockade (NMB) (Train-of-four count = 3; TOFc 3) to Train-of-four…
- Trial name
- NCT05037006
- Testing
- Sevoflurane - Neostigmine 30, Sevoflurane - Neostigmine 50, Sevoflurane - Neostigmine 70
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Neuromuscular Blockade
Sugammadex Dose Finding Under Two Years Old
This is a prospective dose-finding study of sugammadex for conventional reversal of rocuronium-induced neuromuscular blockade in children under two years of age.
- Trial name
- NCT06575036
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Sang-Hwan Ji
Acute Respiratory Distress Syndrome
Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)
Mortality in Acute Respiratory Distress Syndrome is high (40 to 60 %). Protective mechanical ventilation, until 2010, was the cornerstone of the ARDS therapeutic strategies.
- Trial name
- NCT01573715
- Testing
- NIMBEX, WITHOUT NIMBEX
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Postoperative Pain, Lung Cancer
Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades
To investigate the effect of liposomal bupivacaine compared with bupivacaine hydrochloride for intercostal blockades for patients undergoing Video-assisted thoracoscopic surgery.
- Conditions
- Postoperative Pain, Lung Cancer, Video Assisted Thoracoscopic Surgery, Blockades Neuromuscular
- Trial name
- NCT05038007
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Jannie Bisgaard Stæhr
Brain Tumor
MEP and Neuromuscular Blocker
It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the…
- Trial name
- NCT04768400
- Testing
- Arm I (MEP)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Gangnam Severance Hospital
Neuromuscular Blockade
The Effect of Deep Neuromuscular Blockade on Respiratory Mechanics
This study is a randomized, controlled, double-blinded, and parallel design study. A total 58 patients were randomized to receive a deep block or a moderate block scheduled for elective robot assisted laparoscopic radical…
- Trial name
- NCT04174222
- Testing
- Moderate NMB, Deep NMB
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Blockade
Sciatic Nerve Block Using the Subgluteal Space Approach: A Comparison With the Infragluteal Approach
A new ultrasound-guided "subgluteal space" approach to sciatic nerve block that has been recently described obviates the need to identify the sciatic nerve.
- Trial name
- NCT01814605
- Testing
- Infragluteal space group, Subgluteal space group
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University Health Network, Toronto
Radiculopathy, Radiculopathy Lumbar
Evaluation of Erector Spina Plane Block(ESPB)'s Effectiveness on Patients With Lumbar Radiculopathy
A new regional anaesthetic block technique is described in this issue of Anaesthesia by Chin et al. whereby local anaesthetic is injected within a plane beneath the erector spinae muscle to achieve analgesia for abdominal…
- Conditions
- Radiculopathy, Radiculopathy Lumbar, Pain, Back
- Trial name
- NCT05261581
- Testing
- Erector Spinae Plane Block, NSAID, Home Exercise Programme
- Where
- Turkey (Türkiye)
- Sponsor
- Bezmialem Vakif University
Peripheral Chemosensitivity
The Breath-2 Trial
This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation
- Trial name
- NCT05149872
- Testing
- Muscle relaxation, Reversal
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
TOF
Residual Neuromuscular Blockade and PACU Admission
Residual neuromuscular blockade (RNMB) remains an underrecognized postoperative safety concern associated with pulmonary complications, prolonged post-anesthesia care unit stay, and reduced patient satisfaction.
- Trial name
- NCT07758868
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people
- Sponsor
- Ankara Etlik City Hospital
Sciatica Acute
Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care
The goal of this clinical trial is to compare transgluteal sciatic nerve block to standard of care to treat sciatic back pain in adult patients who present to the emergency department.
- Trial name
- TGSNB vs SoC (NCT07397117)
- Testing
- nerve block with ropivacaine, Standard medical treatment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Postoperative Complications, Neuromuscular Blockade
An Observational Study to Analyze the Prescription Pattern of Sugammadex and Its Effectiveness and Safety
The purpose of this observational study is to evaluate patients who are planning to administer sugammadex after rocuronium or vecuronium is used. The main questions it aims to answer are: 1. Prescription pattern of sugammadex 2.
- Conditions
- Postoperative Complications, Neuromuscular Blockade, Anesthesia
- Trial name
- SECURE (NCT05788718)
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 6,458 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Mechanomyography, Neuromuscular Blockade Monitoring
The TOF3D Mechanomyograph. Evaluation of a New Device for Assessment of the Neuromuscular Block.
In clinical anesthesiologic practice, most institutions use acceleromyography in order to assess the degree of a neuromuscular block. The aim of the present study is to assess a new device using mechanomyography.
- Trial name
- MMG versus AMG (NCT07371377)
- Testing
- measurement of the time course of a neuromuscular block
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Klinikum Hersfeld-Rotenburg
Refractory Myositis
Treatment With TNF Blockade, Infliximab, in Patients With Myositis
This is a 4 month open trial with TNF-blockade using infliximab (an antibody that blocks TNF) in adult patients with chronic myositis (polymyositis, dermatomyositis, inclusion body myositis) who have persisting muscle weakness…
- Trial name
- NCT00443222
- Testing
- Infliximab
- Sponsor
- Karolinska Institutet
Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
This study is a clinical research project conducted at Xijing Hospital to compare the effects of two different neuromuscular blockade reversal strategies on the recovery of gastrointestinal (GI) function after colorectal surgery.
- Conditions
- Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus, Colorectal Surgery
- Trial name
- NCT07271875
- Testing
- Neostigmine + Atropine, Sugammadex
- Volunteers
- 560 people
- Sponsor
- Xijing Hospital
Complex Regional Pain Syndromes
Thoracic Sympathetic Ganglion Block With Botulinum Toxin Type A
Thoracic sympathetic ganglion block is a percutaneous procedure that paralyzes the action of sympathetic nerves transiently by injecting a local anesthetic around the ganglion.
- Trial name
- NCT06470581
- Testing
- Botulinum toxin A
- Volunteers
- 78 people
- Sponsor
- Seoul National University
Neuropathic Pain, Amputation, Traumatic
Postamputation Pain: Peripheral Mechanisms
Stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. It has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain…
- Conditions
- Neuropathic Pain, Amputation, Traumatic, Nerve Block, Phantom Limb Pain
- Trial name
- NCT03317600
- Testing
- Lidocaine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Pain Research Center