Clinical trials: Neuromuscular Blockade
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Myofascial Trigger Point Pain
Integration of Neuromuscular Inhibition Technique On Trapezius Trigger Points.
The purpose of the study is to find the effects of integrated neuromuscular inhibition technique on upper trapezius trigger points in patients with non specific neck pain.
- Trial name
- NCT04993118
- Testing
- Integrated Neuromuscular Inhibition technique, Ischemic Compression,Hotpack,TENS
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pain Syndrome, Pain, Intractable
Determination of Longus Colli Muscle Thickness by Ultrasonography
This study aims to assess the longus colli muscle thickness by ultrasonography in order to guide stellate ganglion blocks
- Conditions
- Pain Syndrome, Pain, Intractable, Complex Regional Pain Syndromes, Hyperhidrosis
- Trial name
- NCT05108103
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Muscle Relaxants
Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle relaxants are medications used during surgery to facilitate surgical access. The effect of the muscle relaxant medications is measured by stimulation a motor nerve and measuring the force of the resultant muscle…
- Trial name
- NCT02425449
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Neuromuscular Blockade
Comparison of Neuromuscular Recovery at the Hand and Foot
Gold standard for neuromuscular blockade evaluation is accelerometry in three dimensions at the thumb. There are many times that measurement at the hand can be falsely under-estimated intraoperatively secondary to constriction of…
- Trial name
- NCT06236763
- Testing
- TOFscan foot
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Neuromuscular Blockade
Electromyographic Assessment of the TetraGraph in Normal Volunteers
There is an urgent need for an easy-to-use and accurate quantitative neuromuscular monitor in the clinical setting. The aim of this clinical investigation is to examine a prototype of a quantitative monitoring instrument that…
- Trial name
- NCT02912039
- Testing
- TetraGraph, TOF Watch
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Reversal of Neuromuscular Blockade
A Single Ascending Dose of HRS-2162 in Healthy Subjects
The study is being conducted to evaluate the safety and tolerability of HRS-2162 injection in a single dose in healthy subjects, as well as the characteristics of PK/PD
- Trial name
- NCT07195604
- Testing
- HRS-2162
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Critical Illness Polyneuropathy, Critical Illness Myopathy
Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients.
Patients suffering from critical illnesses who are admitted to the Intensive Care Unit (ICU) are often affected by multiple organ failure.
- Conditions
- Critical Illness Polyneuropathy, Critical Illness Myopathy, Weakness Due to Disease, Neuromuscular Blockade
- Trial name
- NCT03893058
- Where
- Italy
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Gynecologic Disease, Neuromuscular Blockade
Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum
The investigators hypothesized that deep neuromuscular block compare to moderate neuromuscular block would reduce the rate of increasing intraabdominal pressure and operation can be completely done in lower pressure…
- Trial name
- NCT05689957
- Testing
- Deep neuromuscular block using intravenous rocuronium induction at 1.2mg/kg and maintainance of 8-12mcg/kg/min for deep neuromuscular block
- Where
- Malaysia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Skeletal Muscle Relaxation
A Study to Evaluate the Safety, Tolerability and Dose-Response Relationship of HRS-9190 in Healthy Subjects
This is a single-center, open-label and dose-escalation study to evaluate the safety, tolerability and dose-response relationship of HRS-9190 in healthy adults.
- Trial name
- NCT06932315
- Testing
- HRS-9190 for Injection
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Observation of Neuromuscular Block
Train of Four Motor Point Stimulation and Monitoring
The assessment of neuromuscular blockage is common practice in the operating room, in which such agents are employed. Still today, the use of simple hand held stimulators and visual monitoring of these responses are the norm.
- Trial name
- NCT02591108
- Testing
- Neuromuscular Block Aid, Standard of Care: Microstim Plus
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Nerve Block, Neuromuscular Blockade
Dosage of Mepivacaine in Ultrasound Axillary Block
The use of ultrasonography as an adjunct to regional anesthesia has significantly increased in recent years. Brachial plexus blockade by an axillary approach is amenable to the use of ultrasound guidance.
- Conditions
- Nerve Block, Neuromuscular Blockade, Anesthesia
- Trial name
- NCT01485653
- Testing
- Mepivacaine
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Muscle Relaxation
Vibration Training and Muscles Properties
Application dose standards have not yet been determined for Whole Body Vibration Training which is subject to studies with different frequencies and amplitudes.
- Trial name
- CT (NCT04012762)
- Testing
- Whole body vibration training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tülay Çevik
Frailty, Caregiver Burden
Benefits of Strength Training in Informal Caregivers of Patients With Alzheimer's Disease
Informal caregivers of people with Alzheimer's disease experience high physical and psychological burden, increasing their risk of frailty, anxiety, and caregiver burnout.
- Conditions
- Frailty, Caregiver Burden, Anxiety
- Trial name
- NCT07388186
- Testing
- Progressive Muscle Relaxation, Functional Strength Training
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Skeletal Muscle Relaxation
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS3797 in Healthy Subjects
This is a single-center, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS3797 in Chinese adults.
- Trial name
- NCT05701826
- Testing
- HRS3797
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Peripheral Chemosensitivity
The Breath-2 Trial
This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation
- Trial name
- NCT05149872
- Testing
- Muscle relaxation, Reversal
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Neuromuscular Blockade
Comparison of Sugammadex and Neostigmine During PACU Stay
Sugammadex was approved for post-operative use in the operating room (OR) and post-anesthesia recovery unit (PACU) of our quaternary facility, Tampa General Hospital.
- Trial name
- NCT04096144
- Testing
- Neuromuscular Blocking Agents
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Relaxation Therapy, Stress, Psychological
Effects of Progressive Muscle Relaxation on Stress and Bowling Skills in Medium Fast Bowlers
The goal of this clinical trial is to learn if a 4-week Progressive Muscle Relaxation (PMR) protocol can manage psychological stress and improve performance in male cricket medium-fast bowlers aged 16-30 years.
- Conditions
- Relaxation Therapy, Stress, Psychological, Athletic Performance, Anxiety
- Trial name
- NCT07731464
- Testing
- Progressive Muscle Relaxation (PMR), Traditional Training / Active Comparator
- Where
- 4 sites in Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Neuromuscular Blockade
Comparison of Two Quantitative EMG Monitors for Deep Neuromuscular Block in Laparoscopic/Robotic and VATS Surgery
The main objective of the study is to compare the frequency of intraoperative spontaneous diaphragmatic movements and breath-initiation efforts in participants undergoing robotic and/or thoracic surgery under deep neuromuscular…
- Trial name
- NCT07706504
- Testing
- TetraGraph (Senzime)-Guided Neuromuscular Monitoring (Dominant Hand), TwitchView (Blink)-Guided Neuromuscular Monitoring (Dominant Hand)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Shoulder Pain, Anesthesia
The Effect of Deep Neuromuscular Block and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity in Shoulder Surgery Using a Deltopectoral Approach
The study evaluates wether deep neuromuscular block during entire surgical procedure to the gleno-humeral joint or the proximal humerus using a deltoideo-pectoral approach results in less muscular damage to the deltoid muscle and…
- Trial name
- NCT03643913
- Testing
- Deep neuromuscular block, Moderate neuromuscular block, Neuromuscular Blocking Agents and reversing agents
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven