Clinical trials: Neuromuscular Blockade
Healthy Volunteers
Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle
The primary purpose of this study is: 1. To evaluate the model determined by the ability of botulism antitoxin (bivalent, Aventis) to neutralize Botulinum toxin in the Extensor Digitorum Brevis model of muscle paralysis in Stage…
- Trial name
- NCT00636519
- Testing
- Botulism Antitoxin Bivalent (Equine) Types A and B, Botulism Antitoxin Heptavalent (Equine) Types A-G
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Dental Anxiety
Comparison Between Jacobson's Progressive Muscle Relaxation Technique and Audio-visual Distraction Technique in Reducing Dental Anxiety in Children During Dental Visit
Dental anxiety is fear associated with the thought of visiting the dentist for preventive care and dental procedures. Children with dental anxiety characterized by crying before dental checkup, tachycardia and aggressively…
- Trial name
- NCT03923088
- Testing
- jacobson's progressive muscle relaxation technique, audio-visual distraction technique
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dina Hussien Abdelhafez
Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Cardiac Surgery Patients
The purpose of this project is to determine if reversal of neuromuscular blockade in cardiac surgery patients expedites time to extubation in fast track patients.
- Trial name
- NCT03574337
- Testing
- Sugammadex, neostigmine/glycopyrolate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Progressive Muscle Relaxation Exercise
The Effect of Progressive Relaxation Exercises in University Students
The aim of this randomized controlled study is to determine the effect of progressive muscle relaxation exercise on mental health and quality of life in university students.
- Trial name
- NCT05808829
- Testing
- Progressive Muscle Relaxation Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Gazi University
Hemodialysis Complication, Hemodialysis
The Effect of Progressive Muscle Relaxation Exercises on Depression and Fatigue in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial
This study aims to evaluate the effects of progressive muscle relaxation exercises on depression and fatigue levels in patients undergoing hemodialysis treatment.
- Trial name
- NCT07512895
- Testing
- Progressive Muscle Relaxation Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Primary Dysmenorrhea, Quality of Life
Effect of Progressive Muscle Relaxation Exercise on Primary Dysmenorrhea Menstrual Symptoms and Quality of Life.
In this study, it was aimed to evaluate the effect of progressive muscle relaxation exercise on dysmenorrhea, menstrual symptoms and quality of life in university students with common primary dysmenorrhea.
- Trial name
- NCT05340101
- Testing
- ROGRESSIVE MUSCLE RELAXATION EXERCISE
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gazi University
Neuromuscular Residual Curarization
Comparison of the TOFScan and the WiTOF During Recovery of Neuromuscular Function
The purpose of this study is to compare two neuromuscular blockade monitors on recovery from an ATRACURIUM intra veinous injection for surgery. The TOFscan, a wired connected monitors and the WiTOF, a wireless connected monitor.
- Trial name
- NCT05231525
- Testing
- WiTOF, TOFscan
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuropathy With Antibody A MAG
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a promising growing field (1). Non-invasive and painless, ultrasound provides additional data electroneuromyography (EMG), with a spatial…
- Trial name
- EchoNerf (NCT03008733)
- Testing
- Ultrasound UHF peripheral nerves, Electro myography surface nerves
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Skeletal Muscle Relaxation
A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Bolus and Infusion HRS-9190 in Healthy Adults
This study is divided into two parts. The first part adopts a single-center, randomized, single-blind, placebo-controlled dose escalation trial design to investigate the safety, tolerability, pharmacokinetics (PK), and effects on…
- Trial name
- NCT07142850
- Testing
- HRS-9190
- Where
- China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Neuromuscular Blockade, Neuromuscular Block, Residual
Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children
There is no recent information on the required dose of neostigmine for the reversal of cisatracurium-induced moderate neuromuscular blockade (NMB) [Train-of-four (TOF) count = 1-3)] in children.
- Conditions
- Neuromuscular Blockade, Neuromuscular Block, Residual, Neuromuscular Block Prolonged
- Trial name
- NCT05053594
- Testing
- Neostigmine 10 mcg/kg, Neostigmine 20 mcg/kg, Neostigmine 30 mcg/kg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Postpartum Depression, Progressive Muscle Relaxation
Postpartum Depression and Maternal Attachment
In terms of postpartum care and depression, follow-up and controls should be continued online in order not to interrupt the follow-up and treatment of women.
- Trial name
- NCT05038085
- Testing
- progressive muscle relaxation exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gazi University
Inguinal Hernias
Ilioinguinal Nerve Block With Local Anesthetic vs. Placebo in Inguinal Hernia Repair Under Spinal Anesthesia
Postoperative pain management remains a critical area of concern in surgical practices, especially in procedures involving the lower abdomen and pelvis.
- Trial name
- NCT07049835
- Testing
- Ilioinguinal/iliohypogastric Nerve Block
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Neuromuscular Blockade
Reversal of Neuromuscular Blockade During the General Anaesthesia
There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe…
- Trial name
- NCT04048655
- Testing
- Neostigmine, Combinations
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Healthy Young Adults
The Effects of Quartz Crystal Singing Bowl Music and Guided Relaxation on Mood and Sleep in Rangatahi (Young Adults)
The number of people reporting poor mental wellbeing is increasing, with rates exceeding 25% of the population. Rates of psychological distress in young people (aged 15-24 years) are rapidly increasing but many cannot access…
- Trial name
- NCT07267520
- Testing
- Quartz Crystal Singing Bowl music, Progressive Muscle Relaxation
- Where
- New Zealand
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The University of Waikato
Muscle Relaxation
Stretching Isquiotibials in Water and on Land in Healthy Adutls
Comparison of therapeutic intervention to gain range of motion at the hip joint within therapeutic in water and on land. Stretching is a therapeutic maneuver used to increase the length of shortened soft tissue structures and…
- Trial name
- Flexibility (NCT03350880)
- Testing
- Flexibility training
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Magnesium Sulfate Causing Adverse Effects in Therapeutic Use, Neuromuscular Blockade
Effect of Magnesium on Dose of Rocuronium for Deep Neuromuscular Blockade
It is well known that magnesium enhances the effect of neuromuscular blocking agents such as rocuronium. However, it is not known how much magnesium can reduce neuromuscular blocking agents in maintaining deep neuromuscular…
- Trial name
- NCT04013243
- Testing
- Magnesium Sulfate
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
7-dose Control - Progressive Muscle Relaxation Only, 5-dose - Pairs Progressive Muscle Relaxation With Fruit 5 Consecutive Days
Testing a Novel Stress-induced Eating Intervention for Cancer Prevention
Subjects will be enrolled in a stress-induced eating intervention with 5, 7, or 9 treatments or control. Treatment will comprise imagining a stressful event, engaging in a stress relief activity (Progressive Muscle Relaxation)…
- Conditions
- 7-dose Control - Progressive Muscle Relaxation Only, 5-dose - Pairs Progressive Muscle Relaxation With Fruit 5 Consecutive Days, 7-dose - Pairs Progressive Muscle Relaxation With Fruit 7 Consecutive Days, 9-dose - Pairs Progressive Muscle Relaxation With Fruit 9 Consecutive Days
- Trial name
- NCT03468257
- Testing
- Pavlovian Conditioning
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Underdosing of Unspecified General Anesthetics
Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade
Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for…
- Trial name
- NCT02454868
- Testing
- Remifentanil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brasilia University Hospital
Neuromuscular Block
The Influence of Intravenous Lidocaine on the Action of the Neuromuscular Blocker Rocuronium
Lidocaine is a local anesthetic which is widely used in daily anesthesia and surgical practice. It has been shown that intravenous lidocaine given during an operation has analgesic properties.
- Trial name
- LidoRoc (NCT00828373)
- Testing
- Lidocaine
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Neuromuscular Blockade
The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery
This study aims to compare the use of sugammadex (domestic) and neostigmine for antagonism after thoracic surgery, and observe the effect of sugammadex (domestic) on neuromuscular blockade antagonism after thoracic surgery, in…
- Trial name
- NCT06334562
- Testing
- SUGAMMADEX SODIUM 100 Mg in 1 mL, Neostigmine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine