Clinical trials: Neuromuscular Disease Patients
Glioma, Neurofibromatosis Type 1
MicroRNAs in Patients With Neurofibromatosis Type 1
MicroRNAs are small molecules which have recently been discovered in cells. They are known to be responsible for the normal development of cells and when they are disrupted can contribute to the development of cancer.
- Trial name
- NCT01595139
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Carpal Tunnel Syndrome (CTS)
Streamlining Care for Patients With Compression Neuropathies: The Carpal Tunnel Plus Pathway
The goal of this clinical trial is to assess the impact of a new care pathway (the Carpal Tunnel Plus Pathway) in patients with carpal tunnel syndrome. The main questions it aims to answer are: 1.
- Trial name
- CTS+ Pathway (NCT06717477)
- Testing
- Changes to the care pathway for carpal tunnel syndrome (The Carpal Tunnel Plus Pathway)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of British Columbia
Obesity, Chronic Pain
Chronic Abdominal Pain After Laparoscopic Sleeve Gastrectomy
The study aims to evaluate the prevalence of postoperative chronic pain, defined as the persistence of abdominal pain for more than 3 months after laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Chronic Pain, Abdominal Pain
- Trial name
- Chron Pain LSG (NCT06686875)
- Testing
- Questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Duchenne Muscular Dystrophy
Evaluation of Brain Dysfunction in Patients with Duchene Muscular Dystrophy
To study the cognitive function \& psychiatric aspects of patients with DMD by specific psychometry tests \& its relation to quality of life of the patients To evaluate brain structural changes using MRI and correlate them to the…
- Trial name
- NCT06732011
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bulbar Palsy
Stellate Ganglion Block in Bulbar Palsy
This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine in 3 hospitals in China.
- Trial name
- NCT06319534
- Testing
- Comprehensive rehabilitation, Stellate ganglion block, Lidocaine Hydrochloride
- Where
- 6 sites in China
- Volunteers
- 124 people
- Sponsor
- Zeng Xi
Generalized Myasthenia Gravis
Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab for the treatment of participants with generalized myasthenia gravis (gMG).
- Trial name
- NCT03920293
- Testing
- Ravulizumab
- Where
- 106 sites in United States, Austria and 13 more
- Volunteers
- 175 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Spasticity, Multiple Sclerosis
One Year Extension Study To Protocol C2/5/TZ:MS-05
Open label, one year extension study to evaluate the clinical efficacy and safety of 12 mg sublingual tizanidine administered once nightly in MS patients who successfully completed Phase I/II protocol C2/5/TZ:MS-05 at the Tel…
- Trial name
- NCT00464958
- Testing
- sublingual tizanidine 12 mg
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Teva GTC
Maxillary Neoplasms
Prevalence of Trismus in Patients With Maxillary Cancer With and Without Radiation Therapy in the Egyptian Population.
This study aims at evaluating the prevalence of trismus among maxillary cancer patients in the Egyptian population and the effect of radiotherapy on the occurrence of trismus.
- Trial name
- NCT05091814
- Testing
- radiotherapy
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Cairo University
Familial Dysautonomia
The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia
Familial dysautonomia (FD) is a devastating hereditary disease in which the development of selective neuronal populations is impaired because of a deficiency of the protein IKAP (Slaugenhaupt, 2002). There is no known cure.
- Trial name
- NCT02276716
- Testing
- Phosphatidylserine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- NYU Langone Health
Myasthaenia Gravis
Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis
The AURORA Study is evaluating the safety, tolerability, and efficacy of an investigational mRNA CAR T-cell therapy known as Descartes-08 in adults with acetylcholine receptor autoantibody -positive generalized myasthenia gravis.
- Trial name
- NCT06799247
- Testing
- Decartes-08
- Where
- 34 sites in United States, Canada and 6 more
- Volunteers
- 128 people
- Sponsor
- Cartesian Therapeutics
Amyotrophic Lateral Sclerosis
Colchicine Effect on Amyotrophic Lateral Sclerosis Patients
The goal of this clinical trial is to evaluate whether low-dose colchicine can slow disease progression in patients with amyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disorder affecting motor…
- Trial name
- CO-ALSII (NCT07813858)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- 5 sites in Italy
- Volunteers
- 87 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Muscular Atrophy, Spinal
A Real-world Study of Disease-modifying Therapy Treatment Outcomes in Patients With Spinal Muscular Atrophy
The aim of this study was to evaluate treatment patterns, SMA-related complications and services, and all-cause medical encounters of patients with SMA receiving multiple DMTs in the real world.
- Trial name
- NCT07403214
- Where
- United States
- Volunteers
- 4,805 people
- Sponsor
- Novartis Pharmaceuticals
Subacromial Impingement Syndrome
PNF in Subacromial Impingement Syndrome
Although proprioceptive neuromuscular facilitation (PNF) techniques have been used in the treatment of different shoulder problems, PNF techniques in scapular and upper trunk patterns with extremity pattern have not been…
- Trial name
- NCT04794933
- Testing
- Conventional therapy, CT+ PNF in extremity pattern, CT+ PNF in extremity pattern+PNF in scapula and upper trunk patterns
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara Yildirim Beyazıt University
Obese Patients, Laparoscopic Colorectal Surgery
Pharmacodynamics of Injection of Cisatracurium Base on Lean Body Mass Pattern to Maintain Deep Neuromuscular Blockade in Obese Patients
To observe the pharmacodynamics of intravenous injection of cisatracurium to maintain deep neuromuscular blockade in obese patients with lean body mass in laparoscopic colorectal surgery
- Trial name
- NCT05391958
- Testing
- base on Lean Body Mass Pattern, base on Actual Body Weight, obese patients
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
PARKINSON DISEASE (Disorder), Sarcopenia
Effects of Resistance and Aerobic Exercises on Walking and Sarcopenic Parameters in Parkinson's Disease
The aim of this study was to investigate the effects of resistance and aerobic exercises on the following outcomes in patients with sarcopenic Parkinson's disease: Timed Up and Go Test (TUG), gait speed, Short Physical…
- Trial name
- NCT07165106
- Testing
- Aerobic Exercise, Resistance Exercise, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Diabetic Polyneuropathy
Safety and Efficacy of MCC-257 in the Treatment of Diabetic Polyneuropathy
The primary objectives of the study are to evaluate the efficacy and safety of three doses of MCC-257 in patients with mild to moderate diabetic polyneuropathy
- Trial name
- NCT00307749
- Testing
- MCC-257
- Volunteers
- 420 people
- Sponsor
- Tanabe Pharma Corporation
Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction
Cardiac Amyloidosis in HFpEF Tunisian Patients
Cardiac amyloidosis (CA) has recently been reported as a common cause of heart failure with preserved left ventricular ejection fraction (HFpEF), with a prevalence of 6% in elderly HFpEF patients.
- Conditions
- Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction, Echocardiography, CMR
- Trial name
- Amy-Card (NCT06201832)
- Where
- Tunisia
- Volunteers
- 87 people
- Sponsor
- University Tunis El Manar
Muscular Dystrophies
A Phase I/II, Open Label, Escalating Dose, Pilot Study to Assess Effect, Safety, Tolerability and PK of Multiple SC Doses of Drisapersen in Patients With Duchenne Muscular Dystrophy and to Assess the Potential for IV Dosing as an Alternative Route of Administration
The purpose of the extension phase of this study is to determine whether Drisapersen is effective in the treatment of boys with Duchenne muscular dystrophy resulting from a mutation thought to be corrected by exon 51 skipping.
- Trial name
- NCT01910649
- Testing
- Drisapersen
- Volunteers
- 12 people
- Sponsor
- BioMarin Pharmaceutical
Heart Failure, Sarcopenia
Mechanism of Sarcopenia in Heart Failure
The aim of the study is to provide information on the interaction between socioeconomic factors, daily physical activity, nutrition and lifestyle on loss of muscle mass and muscle function in patients with heart failure.
- Conditions
- Heart Failure, Sarcopenia, Cachexia
- Trial name
- MUSCLE-CHF (NCT05063955)
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Multiple Sclerosis, Relapsing-Remitting, Pain, Chronic
The Effects of Relaxation Techniques on Pain, Fatigue and Kinesiophobia in Multiple Sclerosis Patients: A Three Arms Randomized Trial
Even though, current treatments including IVIG, corticosteroids, biological agents can provide positive effects on MS symptoms, MS cannot be cured completely today.
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Pain, Chronic, Fatigue Syndrome, Chronic, Kinesiophobia
- Trial name
- NCT04833673
- Testing
- PMR: Progressive Muscle Relaxation, BRT:Benson Relaxation Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hacettepe University
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