Clinical trials: Neuromuscular Disease Patients
Amyotrophic Lateral Sclerosis
An Intermediate Size Expanded Access Protocol of AMX0035 for ALS
The Expanded Access Program will provide access and assess the safety of AMX0035 for the treatment of people living with ALS.
- Trial name
- NCT05286372
- Testing
- AMX0035
- Where
- 21 sites in United States, Puerto Rico
- Sponsor
- Amylyx Pharmaceuticals Inc.
Trigeminal Neuralgia, Multiple Sclerosis
Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - a Prospective Study in 60 Patients
Clinical characteristics, neuroanatomical findings and efficacy of medical and surgical treatment of symptomatic trigeminal neuralgia - a systematic prospective study of 60 consecutive patients
- Conditions
- Trigeminal Neuralgia, Multiple Sclerosis, Pain, Neuropathic
- Trial name
- NCT04371575
- Testing
- Carbamazepine
- Volunteers
- 60 people
- Sponsor
- Stine Maarbjerg, MD PhD
Back Pain, Failed Back Surgery Syndrome
Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery Syndrome
Low back pain can persist in some patients with history of back surgery. In some cases, an increase in pain may even occur, and chronic pain may make treatment more difficult.
- Conditions
- Back Pain, Failed Back Surgery Syndrome, Neuropathic Pain
- Trial name
- NCT06239857
- Testing
- Epidural pulsed radiofrequency
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Neurofibromatosis 1, Plexiform Neurofibroma
FCN-159 in Adult Patients With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibromas
A study to evaluate the efficacy of FCN-159 in adult patients with symptomatic, inoperable neurofibromatosis type 1-related plexiform neurofibromas.
- Conditions
- Neurofibromatosis 1, Plexiform Neurofibroma, NF1
- Trial name
- NCT05913037
- Testing
- Test group (Group A): FCN-159 8 mg, orally, once daily;
- Where
- 15 sites in China
- Volunteers
- 167 people
- Sponsor
- Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
Fibromyalgia
Comparison of Lymph Drainage and Connective Tissue Massage in Fibromyalgia Patients
The present study was designed to analyze and compare the effects of Manual Lymph Drainage Therapy and Connective Tissue Massage in females with Fibromyalgia (FM).
- Trial name
- FM (NCT00635895)
- Testing
- Manual Lymph Drainage Therapy and Connective Tissue Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Pamukkale University
Polyneuropathy
Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
Even 20-50% of patients under sedation and mechanical ventilation develops myopathy and / or neuropathy which difficulties both the process of extubation and the functional recovery.
- Trial name
- NCT02033057
- Testing
- Muscular electrostimulation and percutaneus muscular biopsy.
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario La Fe
Fibromyalgia
The Effect of Transcutaneous Posterior Tibial Nerve Stimulation in Patients With Fibromyalgia
This study aimed to investigate the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing pain, improving quality of life, and decreasing disease severity in patients with fibromyalgia.
- Trial name
- NCT05937711
- Testing
- Transcutaneous Posterior Tibial Nerve Stimulation + Duloxetine 30 MG, Duloxetine 30 MG
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ilker Fatih Sari
Obstetrical Brachial Plexus Palsy
Study of the Biological Function of Muscle Satellite Cells From Patients With Obstetric Brachial Plexus Palsy
The purpose of this prospective work is to study the consequences of obstetrical brachial plexus paralysis on the rotator muscles of the shoulder.
- Trial name
- SCOPE (NCT05403034)
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Autonomic Nervous System Disease, Amyloid Neuropathies
Autonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart Disease
Transthyretin amyloidosis exhibits a variety of possible phenotypes, the hereditary neurological form being the most commonly found and studied (familial amyloidotic polyneuropathy or FAP), which can present from oligosymptomatic…
- Trial name
- NCT05087953
- Testing
- Head-Up Tilt table test, Heart Rate Variability
- Where
- 3 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Peripheral Neuropathy, HIV
Acupuncture/Moxibustion (Acu/Moxa) for Distal Symmetric Peripheral Neuropathy (DSP) in HIV
This preliminary study will investigate the use of Acupuncture and Moxibustion (Acu/Moxa) for distal symmetric peripheral neuropathy (DSP) associated with HIV applying traditional Chinese medicine (TCM) evaluations conducted by a…
- Conditions
- Peripheral Neuropathy, HIV, AIDS, HIV Infections
- Trial name
- TCMAcuPilot (NCT00826345)
- Testing
- Acupuncture / Moxibustion, Acupuncture/Moxibustion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Neonatal Brachial Plexus Palsy
NMES Efficacy on Patients With NBPP
Neonatal Brachial Plexus Palsy (NBPP), characterized by weakness and sensory loss in the affected arm, results from damage in the prenatal period to the nerves extending from the spine to the arm.
- Trial name
- NCT01999465
- Testing
- Standard NMES device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Endometrial Cancer, Gastrointestinal Stromal Tumor
STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma
RATIONALE: STI571 may interfere with the growth of cancer cells and may be an effective treatment for soft tissue sarcoma. PURPOSE: Phase I/II trial to study the effectiveness of STI571 in treating patients who have recurrent or…
- Conditions
- Endometrial Cancer, Gastrointestinal Stromal Tumor, Ovarian Cancer, Sarcoma
- Trial name
- NCT00006357
- Testing
- imatinib mesylate
- Where
- 16 sites in Belgium, Denmark and 3 more
- Volunteers
- 91 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Healthy, Peripheral Neuropathic Pain
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food-effect of TRK-750
This is an exploratory, randomised, double-blind, placebo-controlled, Phase I study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effect of single and multiple, ascending oral doses of TRK-750 in…
- Trial name
- NCT03346330
- Testing
- TRK-750
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Toray Industries, Inc
Peripheral Neuropathy, Antineoplastic Combined Chemotherapy Protocols
Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy
This study was designed to evaluate the safety and efficacy of Cesamet™ in controlling pain in subjects experiencing pain due to chemotherapy-induced neuropathic pain in patients with cancer.
- Trial name
- NCT00380965
- Testing
- Cesamet™ (nabilone)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- NEMA Research, Inc.
Myasthenia Gravis
A Study to Evaluate the Efficacy, Safety and PD and PK of HBM9161 in MG Patients
Primary Objectives: To investigate the efficacy of HBM9161 in patients with attack of MG in China
- Trial name
- NCT04346888
- Testing
- HBM9161 Injection (680mg and 340 mg), HBM9161 Injection (340 mg)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Harbour BioMed (Guangzhou) Co. Ltd.
Chronic Regional Pain Syndrome
Interest of Day Hospital Care for Patients With Chronic Regional Pain Syndrome Referred to the Chronic Pain Unit for the First Time
Chronic Regional Pain Syndrome (CRPS) is a chronic disabling disease. Patients present a variable picture associating pain localized to an articular or peri-articular region, motor and vasomotor disorders and trophic disorders.
- Trial name
- NCT04913051
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier le Mans
Sarcopenia, Cardiac Surgery
Sarcopenia and Training Outcomes in Post-cardiac Surgery Patients
The goal of this observational study is to assess the prevalence of sarcopenia and see whether the current care is sufficient to improve sarcopenia outcomes in patients after cardiac surgery.
- Trial name
- STRONG (NCT07908472)
- Testing
- No intervention (observational study)
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fibromyalgia
Cost-utility and Immuno-inflammatory Effects of the FIBROWALK in Patients With Fibromyalgia (the On&Out Study)
The present project will evaluate through a randomised controlled clinical trial with 6-month follow-up, the efficacy and cost-utility (6-month time horizon) of the multicomponent FIBROWALK programme in an online (i.e., FIBRO-On)…
- Trial name
- On&Out (NCT05377567)
- Testing
- TAU + FIBRO-On, TAU + FIBRO-Out, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Sarcoma
Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of exatecan mesylate in treating patients who have…
- Trial name
- NCT00041236
- Testing
- exatecan mesylate
- Where
- 10 sites in Belgium, Denmark and 2 more
- Volunteers
- 39 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Fibromyalgia, Vestibular Disease
Effectiveness of Vestibular Rehabilitation for Improving Health Status in Patients With Fibromyalgia
The purpose of this study is to analyze the effectiveness of Vestibular Rehabilitation for improving balance and quality of life of patients with Fibromyalgia Syndrome (SFM).
- Conditions
- Fibromyalgia, Vestibular Disease, Postural Balance, Vestibular Rehabilitation
- Trial name
- NCT05300529
- Testing
- Vestibular Rehabilitation Exercises, Conventional Rehabilitation exercises
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- University of Jaén
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