Clinical trials: Neuromuscular Disorder
Optic Neuropathy
Neuromuscular Ultrasonography Assessment of Optic Nerve in Systemic Lupus Eryhematosus
assessing the role of neuromuscular ultrasound in optic nerve involvement in systemic lupus patients.
- Trial name
- NCT05853003
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Amira M elSonbaty
Lumbar Radiculopathy
Effects of Myofascial Release and Nerve Flossing Technique on Pain and Disability in Patients With Lumbar Radiculopathy
Radiculopathy is a clinical condition which involves one or more nerves resulting in impaired function. The site of injury in radiculopathy is at the level of the spinal nerve root.
- Trial name
- NCT06241027
- Testing
- Nerve flossing technique, Myofascial release
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Duchenne Muscular Dystrophy
Heart Rate Variability in Individuals With Duchenne Muscular Dystrophy
A cross-sectional study was carried out, in which 40 boys, aged 11 to 18 years, were evaluated. The recruitment of groups was carried out at the neuromuscular disease outpatient clinic of the Federal University of São Paulo…
- Trial name
- NCT04740554
- Testing
- Duchenne Muscular Dystrophy group with Deflazacort, Duchenne Muscular Dystrophy group with Prednisone/Predisolone, Duchenne Muscular Dystrophy group without Corticosteroids therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fibromyalgia
A Prospective Evaluation of RINCE to Reduce Fibromyalgia Effects - University of Michigan
The purpose of this study is to evaluate the mechanisms of noninvasive cortical electrostimulation therapy known as "Reduced Impedance Noninvasive Cortical Electrostimulation" RINCE)in the management of fibromyalgia.
- Trial name
- PERRFECT-UM (NCT01914679)
- Testing
- RINCE
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Michigan
Duchenne Muscular Dystrophy
Phase 1/2a for Safety, PK and PD of SQY51 in Paediatric and Adult Patients Duchenne Muscular Dystrophy
This is a Phase 1/2a, monocentric, open label study to evaluate the safety, pharmacokinetics, and pharmacodynamics of SQY51 in patients with Duchenne muscular dystrophy
- Trial name
- AVANCE1 (NCT05753462)
- Testing
- Phase 1, SQY51, Phase 2a, SQY51 (cohort 1), Phase 2a, SQY51 (cohort 2)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Sqy Therapeutics
Spasticity, Cerebral Palsy
Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity
Oral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although for adults there is dosing,safety and efficacy information in the package insert, this is not the case for children.
- Trial name
- Best PK/PD (NCT00607542)
- Testing
- baclofen
- Where
- 11 sites in United States
- Volunteers
- 61 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Spinal Muscular Atrophy
Implementation of FEES in Spinal Muscle Atrophy
The major aim of this project is to assess comprehensively frequency and extent of dysphagia and bulbar dysfunction in SMA1, 2, and 3 patients by applying FEES and validated dysphagia scores.
- Trial name
- DYS-SMA (NCT04773470)
- Testing
- Flexible Endoscopic Evaluation of Swallowing
- Where
- Germany
- Volunteers
- 79 people
- Sponsor
- University of Giessen
Sports Physical Therapy
Comparative Effects of High and Moderate Intensity Resistance Training in Young Football Players
Football playing is an intermittent sport requiring high intensity dynamic movements, such as acceleration, sprinting and jumping. Higher levels of strength and power are crucial for young football players.
- Trial name
- NCT06479551
- Testing
- high intensity-low volume resistance training, Moderate intensity-high volume resistance training
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sarcopenia, CKD
The Relationship Between Sarcopenia and Cardiovascular Disease in Chronic Kidney Disease and the Risk Involved.
This study explores the risk factors for sarcopenia in patients with chronic kidney disease and the effects of sarcopenia on cardiovascular disease.
- Conditions
- Sarcopenia, CKD, Cardiovascular Diseases
- Trial name
- NCT05479331
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cirrhosis, Kidney Injury
Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis
The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.
- Conditions
- Cirrhosis, Kidney Injury, Sarcopenia, Frailty
- Trial name
- NCT05389280
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kangbuk Samsung Hospital
Overactive Bladder Syndrome
Comparisons of 3-month Versus 6-month Solifenacin Treatment for Female OAB Patients
To investigate whether prolonged period of treatment (6 months) can have a better therapeutic outcome than conventional period (3 months) of antimuscarinics.
- Trial name
- NCT01876186
- Testing
- Solifenacin for 12 weeks, Solifenacin for 24 weeks
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Stroke
Effect of Neural Constraints on Movement in Stroke
This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity…
- Trial name
- ENCMS (NCT06666673)
- Testing
- Tizanidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Myasthaenia Gravis, Myasthenia
Myasthenia Gravis Foundation of America Global MG Patient Registry
The goal of this observational study is to learn about the experiences of people living with Myasthenia Gravis (MG) in the United States.
- Conditions
- Myasthaenia Gravis, Myasthenia, Myasthenia Gravis Associated with Thymoma, Myasthenia Gravis Crisis
- Trial name
- MGFAPR (NCT06617741)
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Myasthenia Gravis Foundation of America
Chronic Fatigue Syndrome, Behavioral Therapy Targeted to Sleep Problems
Behavioral Insomnia Therapy With Chronic Fatigue Syndrome
The purpose of this study is to determine how best to manage the sleep problems of people with Chronic Fatigue Syndrome. This study is being conducted to determine how improvements in sleep affect other Chronic Fatigue symptoms…
- Trial name
- NCT00540254
- Testing
- Cognitive Behavioral Therapy, Usual Care for Chronic Fatigue Syndrome (Active Control Group)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Peripheral Neuropathy
Nutritional Supplementation With Agmatine Sulfate During Small Fiber Neuropathy
This is a nonblinded Case-only study that evaluates the effects of Agmatine Sulfate on small fiber peripheral neuropathy. Patients will be started on Agmatine sulfate (a metabolite of Arginine) and monitored for two months.
- Trial name
- NCT01524666
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- JFK Medical Center
Poliomyelitis
The Clinical Trial Protocol for the Inactivated Poliomyelitis Vaccine Made From Sabin Strains(Sabin IPV)
Based on pre-clinical trial and phase 1 and phase 2 clinical data and principle of GCP, the objective of phase Ⅲ clinical trial is to evaluate safety and immunogenicity of Inactivated Poliomyelitis Vaccine made from Sabin…
- Trial name
- IPV (NCT01510366)
- Testing
- Inactivated Poliomyelitis Vaccine (Sabin strains), Inactivated Poliomyelitis Vaccine (Salk strains)
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Cervical Radiculopathy
Effects of Laser Guided Cervical Proprioceptive Exercises in Patients With Cervical Radiculopathy
Cervical radiculopathy is a peripheral nervous system condition characterized by pathology of the cervical nerve root. Laser guided proprioceptive exercises shows positive impact in improving Joint sense error.
- Trial name
- NCT06397196
- Testing
- Laser guided proprioceptive exercises, Routine Physical therapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Cancer, Sarcopenia
Personalized Cooking and Nutrition Guidance and Physical Activities Program to Reduce Muscle Loss in Advanced Cancer
People with advanced cancer often lose muscle over time. This can make them weaker, more tired, and reduce their quality of life. Many patients also struggle to eat because of changes in taste, smell, or appetite.
- Conditions
- Cancer, Sarcopenia, Muscle Mass Loss
- Trial name
- NCT07466862
- Testing
- Oncology Dietitian's Standard of Care, Personalized Culinary and Nutrition Therapy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Gali Perel
Depression, Anxiety
Whole Body Hyperthermia Registry Study
This protocol will allow for the implementation of a research registry pertaining to Whole Body Hyperthermia (WBH) use in various subject populations.
- Conditions
- Depression, Anxiety, PTSD, Fibromyalgia
- Trial name
- NCT02174003
- Testing
- High intensity whole-body infrared heating
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Carpal Tunnel Syndrome
The Effect of Perineural Injection Therapy in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel.
- Trial name
- NCT02809261
- Testing
- Ultrasound-guided perineural injection with 5% dextrose, Ultrasound-guided perineural injection with normal saline, Normal Saline
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
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