Clinical trials: Neuron Disease, Motor
Amyotrophic Lateral Sclerosis ALS
Intestinal Microbiome Transplant in ALS
This is a 24-week study of intestinal microbiome transplant in people with ALS. All participants will be evaluated clinically in person for 4 visits. Blood and mailed/ fresh stool samples will also be collected.
- Trial name
- NCT07017946
- Testing
- MTP-101C
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Spinal Muscular Atrophy, Spinal Muscular Atrophy Type II
Spinraza in Adult Spinal Muscular Atrophy
This is a longitudinal, observational study of adult patients with genetically confirmed chromosome 5q SMA to examine the safety, tolerability, and effectiveness of SPINRAZA® (nusinersen) for up to 30 months.
- Conditions
- Spinal Muscular Atrophy, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type 3
- Trial name
- SAS (NCT03709784)
- Testing
- Observational study to examine safety, tolerability, and effectiveness of SPINRAZA® prescribed as part of standard of care, One time survey
- Where
- 11 sites in United States, Canada
- Volunteers
- 148 people
- Sponsor
- Washington University School of Medicine
ALS (Amyotrophic Lateral Sclerosis)
Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS)
The purpose of this study is to study use of advance Digital Health Technologies (DHT) and its validity as measures for assessing progression in Amyotrophic Lateral Sclerosis (ALS) patients.
- Trial name
- NCT05276349
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Amyotrophic Lateral Sclerosis
A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis
The purpose of this study is to evaluate the long-term safety of intramuscular administration of Engensis in Participants with Amyotrophic Lateral Sclerosis who were previously randomized, received treatment, and completed the…
- Trial name
- REViVALS-1B (NCT05176093)
- Testing
- Engensis
- Where
- 2 sites in United States, South Korea
- Volunteers
- 8 people
- Sponsor
- Helixmith Co., Ltd.
ALS, Amyotrophic Lateral Sclerosis
Clinical Trial - Analyzing Participation Experiences Of Amyotrophic Lateral Sclerosis Patients
Clinical trial participation has always been substantially skewed toward certain demographic groups. However, there has been little study on whether trial qualities impact participation in either a positive or negative way.
- Trial name
- NCT05423678
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Amyotrophic Lateral Sclerosis
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Pre-fALS is a prospective natural history and biomarker study of people not yet affected with ALS, but who are at genetic risk for developing ALS.
- Trial name
- Pre-fALS (NCT00317616)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Miami
Muscular Atrophy, Spinal
A Study of RO6885247 in Adult and Pediatric Patients With Spinal Muscular Atrophy (MOONFISH)
This multicenter, randomized, double-blind, 12-week, placebo-controlled multiple dose study will investigate the safety and tolerability of RO6885247 in adult and pediatric patients with spinal muscular atrophy (SMA).
- Trial name
- NCT02240355
- Testing
- RO6885247
- Where
- 26 sites in United States, Canada and 7 more
- Volunteers
- 9 people
- Sponsor
- Hoffmann-La Roche
Amyotrophic Lateral Sclerosis
sCD163 in ALS Patients
Amyotrophic lateral sclerosis (ALS) is a fatal disease with progressive muscle weakness leading to severe disability and eventually death.Since the diagnosis relies on clinical features and electromyographic abnormalities, which…
- Trial name
- NCT02325375
- Testing
- lumbar puncture for spinal fluid and blood sample
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis (ALS)
Oral Nutritional Supplementation in Amyotrophic Lateral Sclerosis (ALS) Patients
The purpose of this study is to determine whether an early oral nutritional supplementation (ONS) in amyotrophic lateral sclerosis (ALS) patients is effective on the treatment of this rapidly progressive disease.
- Trial name
- NUTRALS (NCT02152449)
- Testing
- Oral nutritional supplementation
- Where
- France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Limoges
Child With Cancer, Muscular Atrophy, Spinal
A BHI to Increase Hope Level and Stress Level of Parents With a CMC
Being a parent of a child with medical complexity (CMC) poses an enormous stress because these CMC have a multisystem disease, a severe neurologic condition or cancer which may result in premature death.
- Conditions
- Child With Cancer, Muscular Atrophy, Spinal, Child With Cerebral Palsy, Endocrine System Diseases
- Trial name
- NCT05269693
- Testing
- Brief Hope Intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP)
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American…
- Conditions
- Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT04363684
- Where
- 26 sites in United States, Canada
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Amyotrophic Lateral Sclerosis
Study of Cognitive and Emotional Disorders in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that involves not only motor structures, as was previously thought, but also brain areas dealing with cognition as well as parts of the limbic system.
- Trial name
- SLAMEM (NCT01530438)
- Testing
- MRI + 18FDG-PET + neuropsychological assessments ; 18FDG performed especially for the research
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Amyotrophic Lateral Sclerosis (ALS)
HEALEY ALS Platform Trial - Regimen I NUZ-001
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.
- Trial name
- NCT07410806
- Testing
- NUZ-001
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Merit E. Cudkowicz, MD
Acne Vulgaris
Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris
Patients with acne vulgaris (AV) appeared to be a chronic inflammation with a wide range in teenagers and adult. The protocol design is as follows.
- Trial name
- NCT06108193
- Testing
- topical minoxidil in Acne Vulgaris
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- Chang Gung Memorial Hospital
Muscular Atrophy, Spinal
A Study to Learn About the Long-Term Safety of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Took Part in an Earlier Nusinersen Trial (ONWARD)
In this study, researchers will learn more about the use of nusinersen (BIIB058) in participants with spinal muscular atrophy (SMA).
- Trial name
- ONWARD (NCT04729907)
- Testing
- Nusinersen
- Where
- 39 sites in United States, Brazil and 14 more
- Volunteers
- 115 people
- Sponsor
- Biogen
Motor Neuron Disease, Benign Fasciculation-Cramp Syndrome
Serial Fasciculation Measurements in Motor Neurone Disease
Patients with motor neurone disease (MND) typically experience relentless motor decline and die within three years of symptom onset from respiratory muscle weakness.
- Trial name
- NCT03809845
- Testing
- High-density surface electromyography
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College Hospital NHS Trust
Amyotrophic Lateral Sclerosis
EH301 for the Treatment of ALS
The objective of this trial is to evaluate the efficacy and tolerability of EH301 in patients with amyotrophic lateral sclerosis.
- Trial name
- NCT03489200
- Testing
- EH301
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Elysium Health
Amyotrophic Lateral Sclerosis (ALS)
A Study to Evaluate the Tolerability, Safety and Efficacy of VGN-R13 in Patients with ALS
The purpose of this trial is to evaluate safety and efficacy of intrathecal delivery of VGN-R13 as a treatment of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT06849609
- Testing
- VGN-R13
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Hong Chen
Amyotrophic Lateral Sclerosis
Arimoclomol in Amyotropic Lateral Sclerosis
A multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of arimoclomol in amyotropic lateral sclerosis (ALS)
- Trial name
- NCT03491462
- Testing
- Arimoclomol
- Where
- 29 sites in United States, Belgium and 10 more
- Volunteers
- 245 people
- Sponsor
- ZevraDenmark
Amyotrophic Lateral Sclerosis
Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS)
The purpose of this pilot study is to characterize changes in postural orientation and equilibrium in early diagnosed ALS patient.
- Trial name
- NCT00956501
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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