Clinical trials: Neuron Disease, Motor
Cardiac Arrest
Identification of Neurological Prognostic Markers of Cardiac Arrest Patients Alive on 3rd Day
The aim of the study is to identify prognostication predictors of 6-months neurological outcome in survivors at day 3 after cardiac arrest (CA) treated with therapeutic hypothermia (TH).
- Trial name
- NCT02888184
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
SMA - Spinal Muscular Atrophy
Adrenal& Bone Complications in Paediatric Patients Living With Spinal Muscular Atrophy (SMA)
Spinal muscular atrophy (SMA) is a genetic disorder that is known to cause damage to specialised nerve cells, called motor neurons.
- Trial name
- SMA-ABC (NCT07530926)
- Where
- United Kingdom
- Volunteers
- 550 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Cystinosis, Cystinosis, Nephropathic
Genetic Newborn Screening for Cystinosis and Spinal Muscular Atrophy
Newborn screening in Germany is a voluntary program. Cystinosis and spinal muscular atrophy (SMA) are rare autosomal recessive diseases. They are inherited in an autosomal recessive manner, i.e.
- Conditions
- Cystinosis, Cystinosis, Nephropathic, Spinal Muscular Atrophy
- Trial name
- GENESIS1 (NCT06027385)
- Testing
- molecular-based screening
- Where
- 4 sites in Germany
- Volunteers
- 300,000 people
- Sponsor
- Cystinose Stiftung
Metastatic Breast Cancer
Efficacy Evaluation of Enobosarm Monotherapy in Treatment of AR+/ER+/HER2- Metastatic Breast Cancer
To demonstrate the efficacy of enobosarmin the treatment of androgen receptor positive (AR+) and estrogen receptor positive (ER+) metastatic breast cancer (MBC) as measured by radiographic progression free survival (rPFS).
- Trial name
- ARTEST (NCT04869943)
- Testing
- Enobosarm, Exemestane
- Where
- 54 sites in United States, Poland and 2 more
- Volunteers
- 52 people
- Sponsor
- Veru Inc.
Amyotrophic Lateral Sclerosis, ALS
RolloverTreatment With Triumeq for People With ALS Following the Lighthouse II Trial
Triumeq is an approved medicine for HIV. The effectiveness of Triumeq in Amyotrophic Lateral Sclerosis (ALS) is being investigated in the Lighthouse II trial.
- Trial name
- Lighthouse III (NCT06658977)
- Testing
- Abacavir 600mg, Lamivudine 300mg and Dolutegravir 50mg (Triumeq)
- Where
- 7 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Macquarie University, Australia
Osteopenia, Spinal Muscular Atrophy
Effects of Standing on Non-Ambulatory Children With Neuromuscular Conditions
Children with neuromuscular disabilities and limited ambulation are at significant risk for decreased bone mineral density (BMD) and increased incidence of fracture.
- Conditions
- Osteopenia, Spinal Muscular Atrophy, Cerebral Palsy, Muscular Dystrophy
- Trial name
- NCT02428673
- Testing
- Assisted Standing Treatment Program
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Gillette Children's Specialty Healthcare
Motor Neuron Disease / Amyotrophic Lateral Sclerosis
Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease
A two-arm, individual participant randomised controlled, assessor-blinded trial in 7 MND care centres across Australia will be undertaken.
- Trial name
- 3TLA (NCT05136222)
- Testing
- Intervention polysomnography
- Where
- 13 sites in Australia
- Volunteers
- 244 people
- Sponsor
- University of Melbourne
Amyotrophic Lateral Sclerosis
Study of SPG302 in Healthy Volunteers and ALS Participants
The first-in-human Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SPG302 in healthy volunteers and ALS participants
- Trial name
- NCT05882695
- Testing
- SPG302
- Where
- 4 sites in Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Spinogenix
Amyotrophic Lateral Sclerosis
Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)
To evaluate whether dexpramipexole prolongs the QTc interval when orally administered to healthy volunteers.
- Trial name
- NCT01511029
- Testing
- Dexpramipexole, Moxifloxacin
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Knopp Biosciences
Amyotrophic Lateral Sclerosis (ALS)
Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial
The purpose of this research is to investigate the validity of a previous clinical trial named EH301, which showed beneficial effects of anti-oxidant therapies in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- MICABO-ALS (NCT04244630)
- Testing
- Antioxidants
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Dallas VA Medical Center
Amyotrophic Lateral Sclerosis (ALS), Neuromuscular Diseases
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
This project seeks to investigate the effects of a single acute intermittent hypoxia (AIH) session on respiratory and non-respiratory motor function and EMG (electromyography) activity on patients with ALS (amyotrophic lateral…
- Trial name
- AIH-ALS (NCT03645031)
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Amyotrophic Lateral Sclerosis
A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease
This is a Phase IIa, randomized, open-label, multi-center, multi-dose study for subjects with mild to moderate ALS. The protocol is designed to determine whether ALZT-OP1a treatment will positively impact neuro-inflammatory…
- Trial name
- NCT04428775
- Testing
- ALZT-OP1a (cromolyn)
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- AZTherapies, Inc.
Adjustment Disorder
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to…
- Trial name
- NCT07002034
- Testing
- RE104 for Injection
- Where
- 32 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reunion Neuroscience Inc
Frontotemporal Dementia, Frontotemporal Lobar Degeneration
Neurofilament Surveillance Project (NSP)
This is a biomarker study designed to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control group of individuals without known…
- Conditions
- Frontotemporal Dementia, Frontotemporal Lobar Degeneration, FTD-GRN, FTD
- Trial name
- NCT04516499
- Where
- 8 sites in United States
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- The Bluefield Project to Cure Frontotemporal Dementia
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease
This is a randomised, double-blind, placebo controlled study on a cannabis-based medicine extract (MediCabilis CBD Oil), in patients with Amyotrophic Lateral Sclerosis or Motor Neurone Disease.
- Trial name
- NCT03690791
- Testing
- MediCabilis CBD Oil
- Where
- Australia
- Volunteers
- 17 people
- Sponsor
- Gold Coast Hospital and Health Service
Spinal Muscular Atrophy
Sun May Arise on SMA : Newborn Screening of Spinal Muscular Atrophy in Belgium
Medico-economic study of Newborn screening of Spinal Muscular Atrophy
- Trial name
- NCT03554343
- Testing
- test for SMN1 exon 7 deletion
- Where
- Belgium
- Volunteers
- 136,339 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Amyotrophic Lateral Sclerosis, Neurodegenerative Disease
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular condition characterized by weakness, muscle wasting, fasciculations and increased reflexes.
- Conditions
- Amyotrophic Lateral Sclerosis, Neurodegenerative Disease, Motor Neuron Disease
- Trial name
- BCI (NCT00718458)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Amyotrophic Lateral Sclerosis
A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers and Participants With ALS
The primary purpose of this study is to evaluate the safety and tolerability of prosetin in healthy volunteers and participants with ALS.
- Trial name
- PRO-101 (NCT05279755)
- Testing
- prosetin
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 72 people
- Sponsor
- ProJenX
Amyotrophic Lateral Sclerosis, Motor Neurone Disease
Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project
Amyotrophic Lateral Sclerosis (ALS), the most common form of Motor Neuron Disease (MND), is a neurodegenerative disease. At present there are limited treatment options for this disease which progressively affects physical…
- Trial name
- TechnicALS (NCT06820008)
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- University of Dublin, Trinity College
Spinal Muscular Atrophy, Caregiver Burden
The Burden of Primary Caregivers of Spinal Muscular Atrophy Patients and Their Needs
The purpose of this study is to assess carer burden, needs, and expectations of Spinal Muscular Atrophy Parents
- Trial name
- NCT04228718
- Testing
- Zarit Burden Interview Scale, Family Needs Survey (FNS), Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Marmara University
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