Clinical trials: Neuronal Plasticity
Low Intensity Focussed Ultrasound
Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity
Low-intensity focused ultrasound (LIFUS) has been shown to be an effective and safe non-invasive brain stimulation technique, capable of reaching greater brain depth and a greater spatial resolution than other brain stimulation…
- Trial name
- LIFUS-Pharma (NCT04923659)
- Testing
- Carbamazepine, Lorazepam, Dextromethorphan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Prolonged Pain, Neuroplasticity
Modulatory Effects of Multichannel tDCS During Prolonged Experimental Pain
Corticomotor excitability, pain sensitivity, descending pain control and somatosensory evoked potentials (SEPs) is often altered in acute and chronic pain.
- Conditions
- Prolonged Pain, Neuroplasticity, Brain Modulation
- Trial name
- NCT04165980
- Testing
- transcranial direct current stimulation
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Healthy Young Adult, Neurophysiology
Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- KME-TBS (NCT06799260)
- Testing
- Ketone Monoester (KME), iTBS, cTBS
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Parkinson, Parkinson Disease
Neuroplasticity in Parkinson's Disease
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes…
- Trial name
- NCT05286736
- Testing
- Neuroimaging, Quantitative assessments
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cognitive Flexibility, Emotional Regulation
The STRENGTHEN Study
This study uses two different types of interventions including electrical brain stimulation delivered during sleep, and brief, daily meditation training.
- Trial name
- NCT06267521
- Testing
- Healthy Minds Program, Stimulation in Lab, MRI Scanner
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Women's Health, Brain Plasticity
Effects of Probiotics on Synaptic Plasticity During the Menstrual Cycle
Modulation of our gut microbiota through probiotics, can improve our emotional state, decrease pain sensitivity, improve cognitive processes, increase neurotransmitter levels and alter functional connectivity.
- Trial name
- NCT06213428
- Testing
- Progressive Perfect Probiotic
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Adult Participants, Synaptic Plasticity
Effects of Adolescent Synaptic Pruning
The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based…
- Trial name
- SPA PET (NCT07569718)
- Testing
- PET Imaging Scan using [11C]UCB-J
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beatriz Luna
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation
Measuring rTMS-induced Neuroplasticity With EEG Steady-state Visual-evoked Potentials
The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection…
- Conditions
- Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation, Visual Attention
- Trial name
- NCT05853939
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression
Study of Neuroplasticity on Depressed Patients : Modulation of MEP Induced by Theta Burst Stimulation
Neuroplasticity is supposed to be altered in patients suffering from a Major Depressive Disorder (MDD). Transcranial Magnetic Stimulation is a medical device which measures cerebral plasticity.
- Trial name
- DEPLAS (NCT02438163)
- Testing
- Theta Burst Stimulation
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Schizophrenia
Effects of Varenicline on Plasticity in Schizophrenia
This laboratory pilot study will explore the effects of varenicline tartrate on long-term potentiation (LTP)-like mechanisms of (1) the motor cortex and (2) the dorsolateral prefrontal cortex (DLPFC) and working memory in…
- Trial name
- VAR-PAS (NCT01934023)
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Impact of an Eight Week Exercise Intervention in Treating Major Depressive Disorder
To investigate the impact of a structured eight week exercise intervention as an add-on therapy in treating Major Depressive Disorder.
- Trial name
- NCT03191994
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ontario Institute of Technology
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Breast Pain, Mastalgia
Hormones, Outcomes, and Pain Pathways in Exercise Study
The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the…
- Conditions
- Breast Pain, Mastalgia, Back Pain, Back Pain, Low
- Trial name
- HOPE (NCT07579182)
- Testing
- Interventional Sports bra
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Houston
Dyslexia, Aging Problems
Neuroplasticity of Multisensory Cortical Areas Induced by Musical Training: a Translational Approach (MusicPlast)
Exploiting recent methodological advancements, several neuroimaging studies suggested that multisensory integration emerges from a dynamic interplay of distributed regions operating in large-scale networks.
- Trial name
- MusicPlast (NCT03786185)
- Testing
- MusicPlast, MusicPlast Control
- Where
- Greece
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Joint Loose Bodies
Different Methods of Physical Therapy for Stroke
It is estimated that worldwide, about 15 million people are affected by vascular accident (CVA) per year, and in Brazil, the stroke is a major cause of death and disability, generating too much economic and social impact by…
- Trial name
- NCT02932631
- Testing
- THERAPY CONTROL AND MOVEMENT OF INDUCTION
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Morphine, Itch
A Relation of Morphine-induced Itch and Pain Processing
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1.
- Trial name
- NCT04115462
- Testing
- Morphine, Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Alzheimer's Disease
Enhancing Neuroplasticity and Frontal Lobe Function in Patients With Mild Alzheimer's Disease
The purpose of this study is to determine if a novel brain stimulation approach using magnetic stimulation (Transcranial Magnetic Stimulation [TMS]) can improve memory and thinking processes in individuals with mild Alzheimer's…
- Trial name
- TMS-AD (NCT01847586)
- Testing
- Paired Associative Stimulation, Paired Associative Stimulation-Control
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity.
- Trial name
- NCT03851302
- Testing
- Active Remote Ischemic Conditioning, Isometric hand exercise
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Facial Synkinesis
Functional MRI Study Facial Synkinesis
Rationale. Facial synkinesis is one of the most common consequences after facial paralysis, defined as the inability to move muscles due to nerve damage.
- Trial name
- NCT05121896
- Testing
- MRI Scan
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center