Clinical trials: Neuropathic
Pain, Neuropathic, Pain, Inflammatory
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Phase I Part 1 (single ascending dose): Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to…
- Trial name
- NCT05547503
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Peripheral Neuropathic Pain
Gabapentin and Pregabalin Effects on Inflammation and Cardiac Function in Peripheral Neuropathic Pain
This prospective, controlled, observational cohort study will evaluate short-term changes in inflammatory biomarkers and subclinical cardiac function in adults with peripheral neuropathic pain who are prescribed gabapentin or…
- Trial name
- NCT07755514
- Testing
- Gabapentin, Pregabalin
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Giresun University
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neuropathy, Diabetic, Pain, Neuropathic
Balance and Gait in Diabetic Neuropathy
The aim of the study is to evaluate the effects of neuropathic pain due to type 2 diabetes on balance and gait. The study is a prospective controlled study.
- Conditions
- Neuropathy, Diabetic, Pain, Neuropathic, Gait Disorder, Sensorimotor
- Trial name
- NCT05127538
- Testing
- Gait analysis, Balance Assessment
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Baskent University
Digestive Cancer, Gynecological Cancer
Analysis of Chronic Neuropathic Pain Markers in Patients Treated With Oxaliplatin
The role of oxidative stress in the development of oxaliplatin-induced peripheral neuropathy has been previously described in mice and in neuronal cell cultures (Massicot 2013); clinical manifestations and pathophysiological…
- Trial name
- LIPIDOXA (NCT02169908)
- Testing
- Thermotest, von Frey hairs
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fondation Hôpital Saint-Joseph
Nerve Pain, Neuropathic Pain
PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin
The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain with Spinal or Peripheral Nerve Origin.
- Conditions
- Nerve Pain, Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic)
- Trial name
- NCT06599151
- Testing
- [18F]FTC-146
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Volunteers
Local Anaesthetic Effects of Transcutaneous Amitriptyline
The aim of this study is to assess the local anaesthetic effects of amitriptyline applied on the skin of human volunteers, considering the differential effects on mechanic and thermic sensitivity, the local and general tolerance…
- Trial name
- NCT00355277
- Testing
- Amitriptyline
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Endometriosis
Spinal Cord Stimulation for Intractable Chronic Lower Abdominal Neuropathic Pain Caused by Endometriosis
Endometriosis is a chronic, inflammatory disease where endometrium-like tissue is present outside the uterus. Nerve cells in the proximity of this tissue express cytokine receptors causing a signaling cascade.
- Trial name
- NCT05558540
- Testing
- spinal cord stimulator
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Prof. Velja Mijatovic
Neuropathic Pain
A Study to Assess Safety, Tolerability and Exposure of 4ET1103 in Healthy Human Volunteers
This study will dose healthy human volunteers with either active drug (4ET1103) or placebo. Each study subject will receive a single dose of either active drug or placebo, and will then be monitored for safety, tolerability and…
- Trial name
- NCT07586514
- Testing
- LY4286533
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- 4E Therapeutics
Lumbar Radiculopathy
Comparison of the Efficacy of rTMS and tDCS of the Motor Cortex in Patients With Chronic Neuropathic Pain
The present study aims to compare directly the efficacy of two noninvasive neurostimulation techniques : repetitive transcranial magnetic stimulation and transcranial direct electrical current of the motor cortex in patients with…
- Trial name
- NCT02030626
- Where
- 2 sites in France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospital Ambroise Paré Paris
Complex Regional Pain Syndromes, Healthy
Study of Proteins Associated With Complex Regional Pain Syndrome
This study will try to learn more about complex regional pain syndrome, or CRPS (previously known as reflex sympathetic dystrophy, spreading neuralgia, and sympathalgia), by examining the release of small proteins in the blood of…
- Trial name
- NCT00033969
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Neuropathic Pain, Chronic Pain
Post-operative Thoracic Epidural Analgesia and Incidence of Major Complications: a Large Retrospective Dual Center Experi-ence
A retrospective observational dual center study investigating side effects and major complications after thoracic epidural insertion according to local safety protocols.
- Conditions
- Neuropathic Pain, Chronic Pain, Thoracic Cancer
- Trial name
- NCT05909007
- Testing
- thoracic epidural insertion
- Where
- Greece
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Back Pain, Failed Back Surgery Syndrome
Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery Syndrome
Low back pain can persist in some patients with history of back surgery. In some cases, an increase in pain may even occur, and chronic pain may make treatment more difficult.
- Conditions
- Back Pain, Failed Back Surgery Syndrome, Neuropathic Pain
- Trial name
- NCT06239857
- Testing
- Epidural pulsed radiofrequency
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Non-inflammatory Neuropathic Pain, Healthy Subjects
Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor
Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain.
- Trial name
- LOGIN_NGF (NCT02159170)
- Testing
- NGF injection
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prof Herta Flor
Osteoarthritis, Pain
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
A First-in-Human, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of iN1011-N17 after Oral Administration in Healthy Volunteers.
- Conditions
- Osteoarthritis, Pain, Post Herpetic Neuralgia, Neuropathic Pain
- Trial name
- NCT05496205
- Testing
- iN1011-N17
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- iN Therapeutics Co., Ltd.
Pain
Clonidine-induced Spinal Acetylcholine Release: Normal Volunteers vs. Neuropathic Pain
The purpose of this study is to compare the amount of acetylcholine release after a single injection of clonidine in normal volunteers and individuals with neuropathic pain.
- Trial name
- NCT00350532
- Testing
- clonidine
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Neuropathic Pain
Brain Activation During Thermal Stimulation in Neuropathic Pain
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following…
- Trial name
- NCT00525018
- Testing
- contact heat evoked potential stimulator
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neuropathic Pain, Complex Regional Pain Syndrome
IV Lidocaine Infusion for Neuropathic Pain
The investigators will conduct a retrospective cohort study of patients who have undergone i.v. lidocaine infusions in the previous 2 years for suspected neuropathic pain of heterogeneous origin.
- Conditions
- Neuropathic Pain, Complex Regional Pain Syndrome, Chronic Pain
- Trial name
- NCT05731739
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Trigeminal Neuropathic Pain
Brain as a Therapeutic and Research Target in Trigeminal Neuropathic Pain
The main goal of this study to integrate techniques producing images of the brain (also called neuroimaging techniques) with non-invasive brain stimulation to investigate factors that may be associated with chronic pain in…
- Trial name
- NCT03003715
- Testing
- PET Scans, transcranial direct current stimulation (tDCS), MRI
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Calcitonin, Neuropathic Pain
Calcitonin Therapy on Incidence and Severity of Neuropathic Pain After Spinal Cord Injury
This prospective randomized double blinded study will be conducted to evaluate the effect of early pharmacologic intervention with calcitonin on the incidence or the severity of neuropathic pain after spinal cord injury
- Conditions
- Calcitonin, Neuropathic Pain, Spinal Cord Injury
- Trial name
- NCT05805683
- Testing
- Calcitonin
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Tanta University