Clinical trials: Neuropathy, Diabetic
Diabete Mellitus, Diabetic Foot
Effect of Self- and Family Management of Diabetic Foot Ulcers Programs on Health Outcomes
Brief description: Diabetic foot ulcer (DFU) is described as a full-thickness lesion appearing at the skin of the foot along with infection, destruction of tissues due to neuropathy and/or peripheral artery disease (PAD) in…
- Trial name
- NCT03909802
- Testing
- Self-and family management of diabetic foot ulcers programs, Usual care
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Universitas Muhammadiyah Yogyakarta
Diabetic Foot Ulcer, Diabetic Foot
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care…
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetes
- Trial name
- NCT06104969
- Where
- 9 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of Michigan
Prevention of Diabetic Foot
Musculoskeletal Changes After Physiotherapeutic Intervention in Podiatric Subjects
The recurrence of diabetic foot ulcers (DFU) is a key problem in podiatric care. It is very often given by biomechanical abnormalities frequently present in those patients.
- Trial name
- BIONEDIAN (NCT04257409)
- Testing
- Physical intervention by exercise
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Mgr. Eliška Vrátná
Diabetic Foot, Diabetes Mellitus Type 2
The Effect of Web-Based and Face-to-Face Education Based on the Health Promotion Model on Foot Care Behavior in Individuals With Type 2 Diabetes
Diabetic foot is a complication that develops difficult-to-heal foot wounds, reduces the quality of life of individuals with diabetes, causes loss of productivity, and causes economic burden due to the repetition of the problem…
- Trial name
- NCT06780631
- Testing
- Web-based diabetic foot education based on health promotion model, Face to face diabetic foot education based on health promotion model
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Marmara University
Peripheral Neuropathy, Neuropathic Pain
Safety and Efficacy Study of ADL5859 in Participants With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness of ADL5859 in relieving the pain associated with diabetic peripheral neuropathy (DPN) compared with placebo and duloxetine (a marketed drug approved for the treatment of…
- Trial name
- NCT00603265
- Testing
- ADL5859, Duloxetine
- Where
- 27 sites in United States
- Volunteers
- 226 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Foot Ulcer, Foot Ulcer, Diabetic
Diabetic Foot Ulcer Imaging- Study 2
All study procedures will occur during one appointment. The research team will measure the size of the foot ulcer (if one is present) and multiple photos will be taken with a smart phone camera and thermal camera.
- Trial name
- NCT03942081
- Testing
- Ulcer Measurement Software
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Linnea Polgreen
Diabetic Foot, Staphylococcus Aureus
Evaluation of the Antibiofilmogramme® Test During Diabetic Foot Infections
This is an observational study that does not change routine care. The primary objective of this study is to investigate the role of antibiogramme-antibiofilmogramme concordance (in terms of S.
- Trial name
- BioFilm PieDia (NCT02378493)
- Testing
- Antibiofilmogramme
- Where
- 6 sites in France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Diabetic Foot Ulcer
A Phase 3 Clinical Trial to Assess the Effectiveness of BioChaperone PDGF-BB In the Treatment of Chronic Diabetic Foot Ulcer
The present clinical trial is designed to assess the effectiveness of BioChaperone PDGF-BB applied at 4 µg/cm² every other day for up to 20 weeks and associated to Standard of Care as compared to Standard of Care alone for the…
- Trial name
- NCT02236793
- Testing
- BioChaperone PDGF-BB, Standard of Care
- Where
- 32 sites in India
- Volunteers
- 252 people
- Sponsor
- Adocia
Diabetic Neuropathy, Painful, Diabetic Neuralgia
Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN).
The purpose of this study is to evaluate the safety, effectiveness, and tolerability of 200 mg of RWJ-333369 given twice daily by mouth compared with placebo in the treatment of Diabetic Peripheral Neuropathy (DPN).
- Conditions
- Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy, Diabetic Mononeuropathy
- Trial name
- NCT00501202
- Testing
- RWJ-333369 (carisbamate)
- Volunteers
- 132 people
- Sponsor
- SK Life Science, Inc.
Diabetic Polyneuropathy
Study of Physical Therapy in Patients With Diabetic Polyneuropathy
Sensorimotor diabetic polyneuropathy is a common and serious complication of longstanding diabetes mellitus. The therapeutic options are limited (pain therapy, antidepressants, physical measures using direct current such as two…
- Trial name
- NCT05622630
- Testing
- Four-cell bath, Gravel bath
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Paracelsus Harz Clinic Bad Suderode.
Diabetic Foot
Implementation of the D-Foot at the Department of Prosthetics and Orthotics
Early identification of potential risk factors for the onset of diabetic foot ulcers are recommended. However, in a Swedish context, there has been no standardised routines to be used in the foot screening procedure.
- Trial name
- NCT03088566
- Testing
- The D-Foot method, Conventional foot screening
- Where
- Sweden
- Volunteers
- 111 people
- Sponsor
- Sahlgrenska University Hospital
Diabetic Foot, Ulcer Foot
SDRM® vs. Collagen for Diabetic Foot Ulcers
Supra SDRM® is FDA-cleared as a dressing for treating partial and full-thickness wounds. It is a dermal substitute that provides a barrier and an ECM-like structure to help accelerate wound healing.
- Conditions
- Diabetic Foot, Ulcer Foot, Wound Heal
- Trial name
- NCT05883098
- Testing
- Wound debridement, Wound closure matrix application
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Polymedics Innovations Inc.
Diabetes Complications
Silicone Sock as Treatment of Deep Heel Fissures in People With Diabetes
This study evaluates the addition of using a sock of silicone to using a heel cream, in the treatment of heel fissures in people with diabetes, aiming at healing the fissures and preventing them from developing into ulcers.
- Trial name
- NCT02641548
- Testing
- Sock of silicone, Heel cream
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Region Örebro County
Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation.
- Trial name
- NCT07877948
- Testing
- Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- BREGO Life Sciences
Diabetic Neuropathies
A Randomized Controlled Trial of Mecobalamin Injection and Tablet Treatment Efficacy on Mild to Moderate Diabetic Peripheral Neuropathy
To evaluate the efficacy of mecobalamin injection and tablet in the treatment of small fiber lesions in the early stage of diabetic peripheral neuropathy by corneal confocal microscopy.
- Trial name
- NCT04372316
- Testing
- methylcobalamin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Painful Diabetic Peripheral Neuropathy (PDPN)
Study to Assess Analgesic Efficacy and Safety of ASP3662 in Subjects With Painful Diabetic Peripheral Neuropathy
The purpose of this study is to assess analgesic efficacy of ASP3662 relative to placebo in subjects with painful diabetic peripheral neuropathy (PDPN) as well as assess the safety and tolerability of ASP3662 relative to placebo.
- Trial name
- NCT02372578
- Testing
- ASP3662, pregabalin
- Where
- 37 sites in United States
- Volunteers
- 115 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Foot Ulcer, Diabetic, Diabetic Angiopathies
Efficacy of a Low-Molecular-Weight Heparin (Bemiparin) in the Treatment of Chronic Foot Ulcers in Diabetic Patients
To assess the efficacy of bemiparin (low molecular weight heparin) for 3 months in the treatment of chronic foot ulcers in diabetic patients.
- Trial name
- NCT00399425
- Testing
- bemiparin (low molecular weight heparin)
- Volunteers
- 84 people
- Sponsor
- Spanish National Health System
Diabetic Neuropathy, Painful
A Clinical Trial To Evaluate PF-05089771 On Its Own And As An Add-On Therapy To Pregabalin (Lyrica) For The Treatment Of Pain Due To Diabetic Peripheral Neuropathy (DPN)
The purpose of this study is to evaluate the efficacy and safety of PF-05089771 as a monotherapy and as an add-on to pregabalin for the treatment of painful diabetic peripheral neuropathy (DPN)
- Trial name
- NCT02215252
- Testing
- PF-05089771 150 mg, Pregabalin 300 mg, PF-05089771 150 mg + Pregabalin 300 mg
- Where
- 32 sites in United States
- Volunteers
- 141 people
- Sponsor
- Pfizer
Diabetic Foot Ulcer (DFU), Ulcer Foot
Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs
The purpose of this study is to evaluate the efficacy of four dehydrated complete human placental membrane, also defined as Cellular, Acellular, Matrix-like Products/skin substitutes, plus SOC versus SOC alone in achieving…
- Conditions
- Diabetic Foot Ulcer (DFU), Ulcer Foot, Diabetic Foot, Foot Ulcer
- Trial name
- CAMPSTIM (NCT06449638)
- Testing
- Standard of Care, Revita, Relese
- Where
- 5 sites in United States
- Volunteers
- 272 people
- Sponsor
- StimLabs
Diabetic Peripheral Neuropathy
Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy
DPN often leads to balance issues, sensory deficits, and chronic pain, which can severely impact daily functioning and independence.
- Trial name
- NCT07274735
- Testing
- Intraneural facilitation therapy, Otago exercise program, Intraneural facilitation therapy with Otago exercise program
- Where
- Pakistan
- Volunteers
- 65 people
- Sponsor
- Riphah International University
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