Clinical trials: Neuropathy, Painful
HIV Infections, Peripheral Nervous System Diseases
Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy
The purpose of the study is to determine if an investigational drug, NGX-4010 (high-concentration capsaicin patch), is safe, tolerable and effective in treating painful HIV-associated neuropathy.
- Conditions
- HIV Infections, Peripheral Nervous System Diseases, Pain
- Trial name
- NCT00085761
- Testing
- Capsaicin Dermal Patch
- Where
- 2 sites in United States
- Sponsor
- NeurogesX
Diabetes Mellitus, Painful Diabetic Neuropathy
The Development of Contextual Cognitive Behavioural Approach to PDN
Diabetes mellitus (DM) is highly prevalent, and a significant public health problem. Approximately 25-30% of all individuals with DM develop painful diabetic neuropathy (PDN).
- Trial name
- NCT03700528
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Pain, Peripheral Neuropathy
Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel
This randomized pilot clinical trial studies pregabalin in preventing acute pain syndrome in patients receiving paclitaxel. Pregabalin may control the pain caused by cancer treatment.
- Trial name
- NCT01637077
- Testing
- pregabalin, questionnaire administration
- Where
- 6 sites in United States
- Volunteers
- 46 people
- Sponsor
- Academic and Community Cancer Research United
Sciatica, Sciatica Due to Intervertebral Disc Disorder
Transforaminal Epidural Injection in Acute Sciatica
Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery.
- Conditions
- Sciatica, Sciatica Due to Intervertebral Disc Disorder, Sciatic Radiculopathy
- Trial name
- TEIAS (NCT03924791)
- Testing
- Lidocaine, Methylprednisolone Acetate, Dexamethasone
- Where
- 2 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- C.L.A.Vleggeert-Lankamp
Herniated Disc, Lower Back Pain
Chiropractic Prone Distraction for Lower Back Pain
Back pain is a major cause of disability in the United States. The lifetime prevalence of low back pain is estimated at 60-90%. Back pain has conservatively been estimated to involve total direct and indirect costs of over $25…
- Conditions
- Herniated Disc, Lower Back Pain, Sciatica
- Trial name
- NCT00269503
- Testing
- Prone Distraction, Side-Posture Manipulation, Side-Posture Manipulation & Prone Distraction
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Samueli Institute for Information Biology
Painful Diabetic Neuropathy
Trazodone in Painful Diabetic Neuropathy
The aim of the study is to collect preliminary information on the effect of low doses of trazodone on pain intensity in patients with painful diabetic neuropathy and to evaluate the neuropathic pain symptoms, anxiety, sleep…
- Trial name
- NCT03202979
- Testing
- Trazodone 20 mg, Trazodone 10 mg
- Where
- 20 sites in Czechia, Hungary and 1 more
- Volunteers
- 142 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Lumbar Radiculopathy
Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica
The goal of this clinical trial is to evaluate the effect of Transfer of Energy Capacitive and Resistive (TECAR) on pain, functional disability and electrophysiological parameters in adults with chronic discogenic sciatica .
- Trial name
- NCT07841405
- Testing
- Transfer of Energy Capacitive and Resistive (TECAR) therapy, conventional physical therapy program
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Diabetic Neuropathy
Study of DA-9801 to Treat Diabetic Neuropathy
To evaluate the effectiveness of DA-9801 at 300mg, 600mg, 900mg and placebo, in reducing pain in subjects with diabetic neuropathic pain compared to their baseline values.
- Trial name
- NCT01822925
- Testing
- DA-9801 300mg, DA-9801 600mg, DA-9801 900mg
- Where
- 14 sites in United States
- Volunteers
- 128 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Trigeminal Neuropathy, Traumatic
Botulinum Toxin Injections for Oral Neuropathic Pain
Peripheral painful traumatic trigeminal neuropathy (PPTTN) are poorly relieved by existing treatments which in addition induce many adverse effects.
- Trial name
- TRIGTOX (NCT03555916)
- Testing
- BOTOX®, Allergan
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carpal Tunnel Syndrome
Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery
Adequate pain relief has been a priority of the Joint Commission and is featured on national inpatient surveys such as the H-CAHPS.
- Trial name
- NCT01588158
- Testing
- Acetaminophen, Vicodin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
HIV, Peripheral Neuropathy
OPEN Study: Pain Management Treatment Needs Interviews
Presently, there are few options for medically managing HIV-related painful peripheral sensory neuropathy (HIV-SN). Psychological treatments, including Cognitive Behavioural Therapy (CBT), represent a potentially viable addition…
- Trial name
- NCT02972606
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- King's College London
Sjogrens Disease, Primary Sjögren's Syndrome Painful Sensory Neuropathies
A Study to Assess Efficacy and Safety of Efgartigimod in Adults With Sjogren's Disease-associated Sensorimotor Polyneuropathy or Sensory Polyneuropathy (SERENITY)
This study aims to assess the efficacy and safety of efgartigimod PH20 in adults with Sjogren's Disease (SjD) associated with nerve damage.
- Trial name
- SERENITY (NCT07760818)
- Testing
- efgartigimod PH20 SC
- Volunteers
- 75 people
- Sponsor
- argenx
Piriformis Muscle Syndrome, Myofacial Pain Syndromes
The Importance of Gluteus Maximus Muscle in Patients With Preliminary Diagnosis of Piriformis Syndrome
Literature shows different pathologies or combination pathologies can cause gluteal region pain and it can be difficult to diagnose.
- Conditions
- Piriformis Muscle Syndrome, Myofacial Pain Syndromes, Piriformis Syndrome
- Trial name
- NCT05271071
- Testing
- Ultrasound guided piriformis muscle and gluteus maximus muscle lidocaine injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Carpal Tunnel Syndrome
Local Injection of Steroid VS.Glucose 5% in Carpal Tunnel Syndrome
To assess pain relief and quality of life among patients with carpal tunnel syndrome after local steroid vs. glucose 5% injection.
- Trial name
- NCT05496764
- Testing
- Dexamethasone, Glucose Injection
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Neuropathy, Postural Balance
Additional Effects of Neural Mobilization on Pain, Balance and Quality of Life in Diabetic Neuropathy
Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, affecting up to 50% of patients and causing pain, numbness, and balance impairments, which increase the risk of falls, ulcers, and reduced quality of…
- Conditions
- Diabetic Neuropathy, Postural Balance, Pain
- Trial name
- NCT07210203
- Testing
- Neural mobilization with Balance training with conventional physical Therapy, Balance Training only with conventional physical therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
Idiopathic Small Fiber Neuropathy
Efficacy and Safety of Pregabalin in Treatment of Neuropathic Pain in Patients With Idiopathic Small Fiber Neuropathy
The purpose of this study is to assess safety and efficacy of treatment with pregabalin in patients with idiopathic small fiber neuropathy proven by skin biopsy.This is an enriched enrollment randomized withdrawal study that…
- Trial name
- NCT02607254
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Painful Diabetic Peripheral Neuropathy (PDPN)
Cryoneurolysis for Painful Diabetic Neuropathy of the Foot
The study is a single-center, randomized, participant- and observer-masked, human-subjects, post-market clinical pilot study to investigate the use of ultrasound-guided percutaneous cryoneurolysis to treat diabetic neuropathy of…
- Trial name
- NCT06646731
- Testing
- cryoneurolysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Intervertebral Disc Displacement, Sciatica
The Effectiveness of Doin (Conduction Exercise) of the Pelvic Joint for HLD With Radiating Leg Pain
A prospective pilot study will be conducted to investigate the effectiveness and safety in herniated lumbar disc (HLD) patients receiving integrative Korean medicine treatment including Doin (conduction exercise) at a Korean…
- Conditions
- Intervertebral Disc Displacement, Sciatica, Sciatic Radiculopathy
- Trial name
- NCT03571503
- Testing
- Doin (conduction exercise), Herbal medicine, Chuna manual therapy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
Bilateral Arthritis of Wrist, Tendinopathy
Vibratory Anesthesia on Pain Following Corticosteroid Injections
This research study aims to evaluate injectional pain at the site of needle insertion for corticosteroid injections (CSI) of the upper extremity depending on different modes of anesthetics.
- Conditions
- Bilateral Arthritis of Wrist, Tendinopathy, Arthropathy, Compression Neuropathy
- Trial name
- NCT07553273
- Testing
- Digivibe Device
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Chemotherapy-induced Peripheral Neuropathy
A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)
The investigators propose that using the Diode Laser fiber type Selective Stimulator (DLss) in patients with chemotherapy-induced peripheral neuropathy (CIPN) will allow for the assessment of changes in small-fiber pain…
- Trial name
- NCT03687970
- Testing
- Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine