Clinical trials: Neuropathy
Chronic Ulcer, Venous Ulcer
Efficacy of PICO Single-use System in Chronic Ulcers
A clinical trial will be carried out comparing the efficacy of PICO system based on negative pressure therapy (NPT) in adults with chronic ulcers compared to conventional treatments.
- Conditions
- Chronic Ulcer, Venous Ulcer, Diabetic Foot Ulcer, Pressure Injury
- Trial name
- NCT05877378
- Testing
- Single-use negative pressure therapy (PICO)
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to collect 650 blood and 300 cerebrospinal fluid (CSF) samples from people with amyotrophic lateral sclerosis (ALS), pure lower or upper motor neuron diseases, as well as other neurodegenerative…
- Conditions
- Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, Primary Lateral Sclerosis, Nervous System Diseases
- Trial name
- BIO_ALS-01 (NCT00677768)
- Testing
- No intervention
- Where
- 30 sites in United States, Canada
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Amyloidosis Cardiac, Virtual Reality
Virtual Reality Assisted Patient Empowerment: Diagnose ATTR-Amyloidosis And Start Treatment
ATTR amyloidosis is a serious condition with significant morbidity and mortality. In Germany, there are numerous unreported cases of untreated patients, and diagnosing and initiating treatment often requires multiple specialized…
- Trial name
- VRAP-DAAST (NCT05938218)
- Testing
- Intervention
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Neuropathy in Cancer Patients
The purpose of this prospective study is to perform Nerve conduction test, Vitamin D, Vitamin B12 and NADPH oxidase 4(NOX4) expression to assess severity of chemotherapy induced Peripheral neuropathy (CIPN) in solid cancer (Head…
- Trial name
- CIN (NCT06491082)
- Testing
- Cisplatin, Carboplatin, Paclitaxel, Docetaxel
- Where
- India
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Swami Rama Himalayan University
Diabetic Neuropathy, Neuropathic Pain
Pain In Neuropathy Study
In the context of peripheral neuropathy, we will aim to elucidate correlates between sensory symptoms and: Sensory nerve dysfunction. Cutaneous small nerve fibre innervation density. Psychological co-morbidity.
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Chronic Pain, Carpal Tunnel Syndrome
- Trial name
- PINS (NCT02672059)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- King's College London
Diabetic Foot Ulcers, Vitamin D Deficiency
Vitamin D Treatment of Diabetic Patients With Foot Ulcers
The purpose of this study, is to determine whether daily supplements of vitamin D improves wound healing in diabetic patients with chronic foot ulcers.
- Trial name
- NCT03813927
- Testing
- Vitamin D
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Diabetic Peripheral Neuropathy (DPN)
The Diagnostic Value of Shear Wave Elastography and Viscosity Imaging Techniques in Diabetic Peripheral Neuropathy
The main objective of this observational study is to evaluate the diagnostic value of multimodal ultrasound for diabetic peripheral neuropathy (DPN).
- Trial name
- NCT06773793
- Where
- 2 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Pancreatic Cancer, ATM, BRCA, Hereditary Cancer
Pancreatic Cancer Registry: For Any Person With a Personal or Family History
The NFPTR was established in 1994 to find the causes of pancreatic cancer. In brief, the investigators are interested in both the genetic and non-genetic causes of pancreatic cancer.
- Trial name
- NFPTR (NCT02886247)
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Amyotrophic Lateral Sclerosis (ALS), Peripheral Neuropathies
Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy
The progress of ALS research and clinical practice is hampered by lack of effective biomarkers to monitor disease onset and progression.
- Trial name
- TUNEABLE (NCT07268833)
- Where
- 4 sites in Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Diabetic Peripheral Neuropathy
The Effect of Related Blood Markers on Diabetic Peripheral Neuropathy
The goal of this observational study is to explore the relationship between related blood indicators and diabetic peripheral neuropathy.
- Trial name
- NCT06041399
- Testing
- hypoglycemic Agents(metformin), lipid-lowering drug(Statin)
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Carpal Tunnel Syndrome
Role of Ultrasonography in the Diagnosis of Carpal Tunnel Syndrome
This prospective study aims to evaluate the median nerve in Carpal Tunnel Syndrome by high-frequency ultrasound and color Doppler in comparison with clinical and Nerve conduction studies.
- Trial name
- NCT04976998
- Testing
- imaging
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Lumbar Radiculopathy
Effect of High Versus Low-level Laser Therapy in Patients of Lumber Radiculopathy
To Compare the effects of high-level laser therapy (HLLT) and low-level laser therapy (LLLT) on pain in patients with lumbar radiculopathy.
- Trial name
- NCT06240845
- Testing
- High-level laser therapy, Low-level laser therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Pancreatitis
Pain Phenotypes in Chronic Pancreatitis
Chronic pancreatitis (CP) is characterised by recurrent abdominal pain. The pathological hallmarks of CP is pancreatic stellate cell activation that results in persistent inflammation and progressive fibrosis.
- Trial name
- PIP (NCT05713344)
- Testing
- Clinical history, Clinical examination, Evaluation of quality of life
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Chronic Pain
Sensory Abnormalities in Post-surgical Peripheral Neuropathy
The concept of normality is a cornerstone in medical practice and research. As an example, in clinical chemistry, a laboratory value based on a plasma sample exceeding the +/- 1.96 x standard deviation (SD) range, referenced from…
- Trial name
- NCT03966677
- Where
- Denmark
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Chemotherapy-induced Peripheral Neuropathy
Evaluation by Oncologists of Strategies for the Prevention and Treatment of Chemotherapy-induced Peripheral Neuropathies
Chemotherapy induced peripheral neuropathy (CIPN) is one of the most deleterious adverse effect of neurotoxic anticancer drugs affecting up to 40% of patients.
- Trial name
- EVANEURO (NCT03854864)
- Testing
- survey
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Neuropathy; Peripheral, Autonomic, in Diabetes Mellitus (Manifestation)
The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy
Exploring the relationship between serum VAP-1 and cardiovascular autonomic neuropathy in subjects with type 2 diabetes mellitus
- Trial name
- NCT01706289
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Radial Palsy
Tendon Transfer for Irreversible Radial Nerve Palsy, Does it Help?Retrospective Cohort From Level-1 Trauma Center.
Radial nerve palsy is associated with serious disability jeopardizing the grasp and power grip accountable to the loss of thumb and fingers extension and loss of active wrist extension respectively.
- Trial name
- NCT03936868
- Testing
- Tendon transfer
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Breast Cancer
Taxane Induced Peripheral Neuropathy in Chinese Patients With Breast Cancer
The purpose of this study is to collect clinical data, blood samples, and self reported symptoms of peripheral neuropathy from Chinese patients with breast cancer after treatment with taxanes.
- Trial name
- NCT04068090
- Testing
- Patient Questionnaires, Blood Collection
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Carpal Tunnel Syndrome
Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?
This study is being conducted to determine whether addition of a longer-acting local anesthetic to our current anesthetic protocol improves the post-operative pain after carpal tunnel release.
- Trial name
- NCT04833777
- Testing
- Local Anesthetics Lidocaine, Local Anesthetics Bupivacaine
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Chemotherapy-induced Peripheral Neuropathy, Peripheral Neuropathy
Visualize Nociceptor Changes in Neuropathic Human
The purpose of this experiment is to establish a solid medical foundation for the successful development of non-invasive harmonic generation (HGM) microscopic slicing methods.
- Trial name
- NCT03112057
- Testing
- harmonic generation (HGM) microscopic methods.
- Where
- Taiwan
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital