Clinical trials: Neuropathy (Disorder)
Small Fiber Neuropathy, Fabry Disease
Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan
Sudoscan™ (Impeto Medical, Paris France) uses electrochemical skin conductance as a novel noninvasive method to detect sudomotor dysfunction.
- Conditions
- Small Fiber Neuropathy, Fabry Disease, Ehlers Danlos Syndrome, Mitochondrial Disease
- Trial name
- NCT02985710
- Testing
- Sudoscan, Skin biopsy, QSART
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dry Needling, Carpal Tunnel Syndrome
Dry Needling and Rehabilitatin Carpal Tunnel Syndrome
Dry needling is used for myofascial release. However, its effectiveness in carpal tunnel syndrome (CTS) is not well known. It is thought that dry needling may also be an effective treatment for CTS by providing relaxation in the…
- Conditions
- Dry Needling, Carpal Tunnel Syndrome, Myofacial Pain
- Trial name
- NCT06358326
- Testing
- Dry needling, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Diabetes Mellitus
INTACT Trial - an Observational Study to Assess Neuropathy in Diabetic Children
It is a prospective, cross-sectional, observational, controlled, single centre clinical study. Diabetic patients fulfilling the inclusion criteria and healthy controls will have uroflowmetry examination, cardiovascular autonomic…
- Trial name
- INTACT (NCT05247840)
- Testing
- uroflowmetry, Cardiovascular autonomic dysfunction test proposed by Ewing et al., peripheral nerve conduction test
- Where
- Hungary
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Heim Pal Children's Hospital
Rehabilitation, Balance
Peripheral Neuropathy Rehabilitation With Stabilometric Platforms (NEUROSTAB)
The goal of this clinical trial is to learn if the GeaMaster stabilometric platform can support rehabilitation and improve balance and walking ability in adults diagnosed with peripheral neuropathy.
- Trial name
- NEUROSTAB (NCT07029620)
- Testing
- Balance and postural rehabilitation using sensor-based stabilometric platform (GEAMASTER) under static and dynamic conditions, Conventional balance and gait rehabilitation program, Stabilometric assessment in healthy volunteers
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Carpal Tunnel Syndrome
Ibuprofen Arginine and Neural Mobilization Versus Ibuprofen Arginine in the Treatment of Carpal Tunnel Syndrome
In the present investigation the pain reduction effects of a physiotherapy technique combined with pharmaceutical ibuprofen arginine treatment will be compared to those produced by ibuprofen (only) treatment, in subjects who…
- Trial name
- NCT06778759
- Testing
- median nerve neural mobilization combined with oral ibuprofen arginine, Ibuprofen Arginine
- Where
- Venezuela
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Metabolic Syndrome, Obesity
Impact of the Metabolic Syndrome on the Incidence of Neuropathy in Obese Subjects
The primary purpose of this study is to discover modifiable risk factors for the development of neuropathy, specifically looking at the metabolic syndrome.
- Conditions
- Metabolic Syndrome, Obesity, Neuropathy
- Trial name
- NCT02689661
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Brian Callaghan
Entrapment Neuropathies
Effect of Different Ultrasound Doses on Median Nerve Conduction Parameters
The current study investigates the effect of different doses of pulses ultrasound therapy on different nerve conduction parameters of the median nerve in healthy volunteering subjects.
- Trial name
- NCT05233488
- Testing
- Pulsed Ultrasound Therapy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
CMT, CMT (Charcot Marie Tooth Disease)
A Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)
The most common inherited neuropathy is Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication of the gene expressing PMP22.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), CMT - Charcot-Marie-Tooth Disease, CMT1A
- Trial name
- CMT-MODs (NCT07476365)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Sciatica
PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
The purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).
- Trial name
- NCT02130271
- Testing
- Radioactive dye, PET/MRI, Blood draw
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Median Nerve Entrapment, Carpal Tunnel Syndrome
Effect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome
The purpose of this study is to examine: 1. The effect of neurodynamic mobilization on the sensory and motor median nerve conduction velocity in carpal tunnel syndrome. 2.
- Trial name
- NCT05788471
- Testing
- conventional Treatment, Neurodynamic mobilization
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hiv
Tui na for Peripheral Neuropathy Among People With HIV
Peripheral neuropathy (PN) is a common neurological complication in people with human immunodeficiency virus (PHIV) with no Food and Drug Administration-approved treatment.
- Trial name
- NCT05596123
- Testing
- Therapeutic Chinese foot massage
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Houston Downtown
Cardiac Amyloidosis
Screening Algorithm for Early Detection of Occult Cardiac Amyloidosis
Early diagnosis of cardiac amyloidosis (CA) is crucial because of the poor overall survival, high mortality and the need for early therapy including new treatment possibilities for transthyretin amyloidosis.
- Trial name
- EARLY-CA (NCT05693376)
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Hip Fracture of Intertrochanteric Type, Thromboembolic Event
Diffrence in Thromboprofilaksis in Elderly Ostoepenic Hip Fractures According to Mobility Status by Genetic Analysis
Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively…
- Conditions
- Hip Fracture of Intertrochanteric Type, Thromboembolic Event, Osteopenia, Thrombosis Embolism
- Trial name
- HSP 47 (NCT06959017)
- Testing
- Gene Expression Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Diabetic Foot Infection
Study of Infrared Thermography in Diabetic Foot in Guadeloupe
It is hypothesized that thermal imaging differs between diabetic and non-diabetic individuals in Guadeloupe. Infrared thermography is also suggested as a useful tool for studying diabetic foot ulceration.
- Trial name
- ETPDG (NCT07040488)
- Where
- Guadeloupe
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Cognitive Impairment, Hereditary Spastic Paraplegia
Studying Cognition in SPG4
Comparing the cognitive levels of patients with SPG4 mutations to healthy controls.
- Trial name
- NCT03104088
- Testing
- CANTAB, MOCA
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
CMT, CMT (Charcot Marie Tooth Disease)
TREMOR IN CHARCOT-MARIE-TOOTH
Tremor is a symptom that has already been described in many case reports and case series concerning patients with Charcot-Marie-Tooth (CMT) disease.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), Charcot Marie Tooth Disease (CMT), Charcot Marie Tooth Disease
- Trial name
- CMT-TREM (NCT07570459)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Diabetic Foot, Diabetic Neuropathies
Peripheral Protective Sensation in Type 2 Diabetes Mellitus
The aim of our study was to investigate the effect of sole sensation on peripheral muscle strength, functional capacity, balance and physical activity level in individuals with Type 2 Diabetes Mellitus.
- Trial name
- NCT05904262
- Testing
- Foot Sole Sensation Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Charcot-Marie-Tooth Disease
Change in MUNIX in Patients With CMT1A Undergoing a Home Ankle Strengthening Program Versus Standard of Care
Here the investigators aim to show that a focused lower extremity resistance strength training program in patients with Charcot-Marie-Tooth disease (CMT) results in increased motor strength of ankle plantar- and dorsi-flexion.
- Trial name
- NCT03715283
- Testing
- Home Ankle Strengthing Program, Standard of Care
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neuropathy; Peripheral, Autonomic, in Diabetes Mellitus (Manifestation)
The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy
Exploring the relationship between serum VAP-1 and cardiovascular autonomic neuropathy in subjects with type 2 diabetes mellitus
- Trial name
- NCT01706289
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diabetic Autonomic Neuropathy Type 2, Perioperative Complication
Effect of Diabetes Mellitus on Cardiac Autonomic Function in Surgical Patients Undergoing General Anesthesia
Because autonomic neuropathy affects the constriction of thermoregulatory blood vessels, it is more difficult for diabetic patients to maintain their own body temperature in cold environments than normal people, and therefore it…
- Conditions
- Diabetic Autonomic Neuropathy Type 2, Perioperative Complication, Temperature Change, Body
- Trial name
- NCT06432270
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital