Clinical trials: Neuropathy (Disorder)
Diabetic Foot Ulcer (DFU)
Acute-to-chronic Glycemic Ratio (ACGR) is a Marker of DFUs .
Diabetic foot ulcers (DFUs) have resulted from peripheral arterial ischemia and peripheral neuropathy that are complicated with infections and amputation of the lower extremities.
- Trial name
- ACGR (NCT06725238)
- Testing
- Acute-to-chronic glycemic ratio
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- University of Diyala
Amyloid Cardiomyopathy
Amyloidosis TTR Flow Reserve Evaluation
Anginal symptoms and signs of ischemia have been reported in some patients with cardiac amyloidosis (TTR) without obstructive epicardial coronary artery disease (CAD).
- Trial name
- AMYTRE (NCT05103943)
- Testing
- SPECT MPI
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Carpal Tunnel Syndrome, Perfusion Index
Is Perfusion Index an Indicator of Block Success in Ultrasound-guided Infraclavicular Brachial Plexus Block
The infraclavicular nerve block, which is frequently preferred in upper extremity surgeries, provides additional advantages such as reduction in opioid consumption by providing analgesic effect in the postoperative period as…
- Trial name
- NCT04921891
- Testing
- Infraclavicular nerve block, Without nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Carpal Tunnel Syndrome, Trigger Finger
Question Prompt List for Common Hand Conditions
Patients with common hand conditions will be randomized to one of two groups- one will receive a question prompt list, the other will receive a list of 3 questions
- Conditions
- Carpal Tunnel Syndrome, Trigger Finger, Trigger Thumb, Dupuytren Contracture
- Trial name
- NCT03868449
- Testing
- Question Prompt List, 3 questions
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Stanford University
Diabetes Mellitus, Diabetic Neuropathies
Vitamin B12 Supplementation in Diabetic Neuropathy
This prospective double-blind placebo-controlled trial aims to investigate the safety and efficacy of oral dispersible tablet of vitamin B12 for 1 year, in 90 patients with diabetes mellitus type 2 and neuropathy.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Diabetic Complication, Diabetic Foot
- Trial name
- NCT04706377
- Testing
- B12 fix 1000mcg
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Aristotle University Of Thessaloniki
Diabetic Foot
Efficacy and Safety of Heberprot-P® in Patients With Advanced Diabetic Foot Ulcer in Dasman Diabetes Institute.
The purpose of this study is to assess the efficacy and safety of the intralesional administration of Heberprot-P® (human recombinant epidermal growth factor) plus the standard treatment in patients with complex diabetic foot and…
- Trial name
- NCT03239457
- Testing
- Heberprot P
- Volunteers
- 50 people
- Sponsor
- Dasman Diabetes Institute
Tuberous Sclerosis, Subependymal Giant Cell Astrocytoma
Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex
The purpose of the study is to evaluate the safety and potential side effects of everolimus (an experimental drug) on a person with Tuberous Sclerosis Complex who also has been diagnosed with a brain tumor (astrocytoma) The…
- Trial name
- NCT00411619
- Testing
- Everolimus
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neck Pain, Back Pain
Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections
Corticosteroid injections into the epidural space or sacroiliac joint are increasingly used for the treatment of chronic neck, low back, and leg pain.
- Trial name
- NCT01717430
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- University of Manitoba
Critical Illness Polyneuromyopathy (CIPNM), ICU Acquired Weakness (ICUAW)
Electrical Muscle Stimulation (EMS), a Preventive and Therapeutic Tool for Critical Illness Polyneuromyopathy (CIPNM)
The purpose of this study is to investigate the role of EMS as a preventive and therapeutic tool of CIPNM. The investigators hypothesized that EMS will prevent the development of CIPNM or have a beneficial role as a therapeutic…
- Trial name
- NCT00882830
- Testing
- EMS
- Where
- Greece
- Volunteers
- 52 people
- Sponsor
- University of Athens
Carpal Tunnel Syndrome (CTS)
Comparative Effects of Sensory Re-education and Neural Mobilization in CTS Patients
The aim of study is to compare the effects of sensory re-education and neural mobilization in CTS patients.
- Trial name
- NCT06686212
- Testing
- Sensory re-education+ strengthening exercises+ kinesio taping, Neural mobilization+ Strengthening exercises+ Kinesio taping.
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Leber's Hereditary Optic Neuropathy
RHODOS Follow-up Single-visit Study
This study aims to evaluate the current visual acuity of SNT-II-003 participants and compare this with the last visit from the SNT-II-003 study.
- Trial name
- RHODOS-OFU (NCT01421381)
- Where
- 3 sites in Canada, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- Santhera Pharmaceuticals
CIPN - Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
The Influence of Chemotherapy on Position Sense
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent side-effects of chemotherapy, causing sensory and motor symptoms in patients.
- Conditions
- CIPN - Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer
- Trial name
- ProprioCIPN (NCT07367711)
- Testing
- Questionnaire - Edinburgh Handedness Assessment, Questionnaire - QuickDash, Questionnaire - EORTC QLQ-CIPN20
- Where
- Belgium
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Trigger Finger, Trigger Thumb
Clinical Investigation on Safety, Performance and Effectiveness of Sono-instruments
Carpal Tunnel (CT) syndrome is a collection of characteristic symptoms and signs that occurs following compression of the median nerve within the CT.
- Conditions
- Trigger Finger, Trigger Thumb, Carpal Tunnel Syndrome
- Trial name
- SONO-01 (NCT05435950)
- Testing
- Sono-Intruments
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Spirecut
Foot Ulcer, Diabetic
Continuous Diffusion of Oxygen (CDO) Treatment for Healing of Diabetic Foot Ulcers
This is a pilot study. Maximum 30 subjects with a diabetic foot ulcer (DFU) or surgical foot wound will be consented in order to have 20 eligible subjects who will be enrolled and completed the study.
- Trial name
- EO2 (NCT02501538)
- Testing
- Transcutaneous O2 device
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Texas Southwestern Medical Center
Carpal Tunnel Syndrome
Reliability And Validity Of Urdu Version Of Disabilities Of The Arm, Shoulder And Hand Questionnaire
The goal of study is to convert Disabilities Of The Arm, Shoulder And Hand Questionnaire into Urdu and test its reliability and validity among the Pakistani citizens.
- Trial name
- NCT05411068
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Riphah International University
Painful Diabetic Neuropathies
Safety and Efficacy Study for the Treatment of Painful Diabetic Neuropathy
The purpose of this study is to determine if Engensis (VM202) is safe and effective in treating painful diabetic neuropathy.
- Trial name
- NCT01475786
- Testing
- Low Dose: 16 mg Engensis (VM202), High Dose: 32 mg Engensis (VM202)
- Where
- 17 sites in United States, South Korea
- Volunteers
- 104 people
- Sponsor
- Helixmith Co., Ltd.
Diabetic Foot Ulcers
Comparative Study of 3 Dose Regimens of BioChaperone to Becaplermin Gel for the Treatment of Diabetic Foot Ulcer
This is an open-label, active-control, multicentre, parallel group, randomised and dose-finding efficacy and safety study. Compare the efficacy and safety of BioChaperone PDGF-BB applied at 12.5 µg/cm² every two days for up to 20…
- Trial name
- NCT01098357
- Testing
- Biochaperone PDGF-BB Low dose, Biochaperone PDGF-BB High dose, Regranex
- Where
- 7 sites in India
- Volunteers
- 192 people
- Sponsor
- Virchow Group
Diabetic Neuropathy
Cognitive Behavioral Therapy for Painful Diabetic Neuropathy
The primary objective of this study is to evaluate the usefulness of cognitive behavioral therapy (CBT) for the management of painful diabetic neuropathy.
- Trial name
- NCT00830011
- Testing
- cognitive behavioral therapy, standard medical care
- Volunteers
- 80 people
- Sponsor
- VA Connecticut Healthcare System
Peripheral Neuropathy
A Mixed-Methods Exploratory Pilot Study of the Investigational MYNERVA Leia Sensory Prosthesis in U.S. Adults With Peripheral Neuropathy
This is a US-specific pilot study to evaluate the short- and long-term effects of the investigational MYNERVA Leia Sensory Prosthesis on gait, neuropathic symptoms and quality of life in US adults with peripheral neuropathy, and…
- Trial name
- MYN-L001-002 (NCT07840157)
- Testing
- Leia Sensory Prosthesis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mynerva Inc.
Lumbar Spinal Stenosis, Cardiac Amyloidosis
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective.
- Conditions
- Lumbar Spinal Stenosis, Cardiac Amyloidosis, ATTR Amyloidosis Wild Type, ATTR Gene Mutation
- Trial name
- NCT06034405
- Testing
- Tc99-PYP or Tc99-HDMP Scan
- Where
- 6 sites in United States
- Volunteers
- 1,663 people, healthy volunteers welcome
- Sponsor
- Columbia University
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