Clinical trials: Neuropathy (Disorder)
Old Age; Debility, Peripheral Neuropathy
Protective Arm Balance Responses
The overall objective of this study is to investigate the effect of attention control training on reach-grasp stabilizing responses during fall-induced perturbations.
- Trial name
- PAT (NCT06388434)
- Testing
- Protective Arm Balance Response Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetic Foot Ulcer, Diabetic Neuropathy Peripheral
Patients With Diabetic Neuropathy Who Receive Physiotherapy Treatment Will Have a Decrease in Diabetic Foot Ulcers
This study evaluates the effects of a physiotherapy protocol (manual therapy and exercise) in the prevention of diabetic foot ulcers in patients with diabetic neuropathy.
- Trial name
- NCT03725917
- Testing
- Physiotherapy protocol
- Where
- Spain
- Volunteers
- 143 people
- Sponsor
- Universidad Complutense de Madrid
Diabetic Foot Ulcer
3C Patch® Medicare Claims Study
This prospective study will compare incidence rates of complete hard-to-heal diabetic foot ulcer healing in Medicare beneficiaries following application of the 3C Patch® plus usual care, tested against a historical control group…
- Trial name
- NCT03997526
- Testing
- 3C Patch
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Reapplix
Diabetic Foot Ulcer
A Phase 3 Clinical Trial to Assess the Effectiveness of BioChaperone PDGF-BB In the Treatment of Chronic Diabetic Foot Ulcer
The present clinical trial is designed to assess the effectiveness of BioChaperone PDGF-BB applied at 4 µg/cm² every other day for up to 20 weeks and associated to Standard of Care as compared to Standard of Care alone for the…
- Trial name
- NCT02236793
- Testing
- BioChaperone PDGF-BB, Standard of Care
- Where
- 32 sites in India
- Volunteers
- 252 people
- Sponsor
- Adocia
Nasopharyngeal Carcinoma, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial
This is a single-center, self-controlled, evaluator-blinded prospective study, which applies pressurized gloves and foot caps to prevent paclitaxel-induced peripheral neuropathy in patients with nasopharyngeal carcinoma.
- Trial name
- CIPN (NCT05531916)
- Testing
- Pressurized gloves and foot caps
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Sun Yat-sen University
Hereditary Spastic Paraplegia
Physiotherapy in Hereditary Spastic Paraplegia
Goal of this study is to develop and evaluate a physiotherapy concept that is focused on bilateral leg spasticity and aims to reduce spastic gait disturbance and to improve mobility in patients suffering from HSP.
- Trial name
- NCT03961906
- Testing
- physiotherapy
- Where
- Germany
- Volunteers
- 53 people
- Sponsor
- University Hospital Tuebingen
HR+ HER2- Breast Cancer
Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer
The study is a Phase 1b/2, multi-center, open-label, dose escalation trial evaluating the safety and preliminary efficacy of sapanisertib and serabelisib (PIKTOR) with fulvestrant and/or other anticancer therapies in participants…
- Trial name
- NCT07558733
- Testing
- Serabelisib, Sapanisertib, Fulvestrant
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- Faeth Therapeutics
Amyloidosis, Hereditary, Amyloidosis Cardiac
Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers
Approximately 1.5 million of the 44 million Blacks in the United States are carriers of the valine-to-isoleucine substitution at position 122 (V122I) in the transthyretin (TTR) protein.
- Conditions
- Amyloidosis, Hereditary, Amyloidosis Cardiac, Amyloidosis, Familial, Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy
- Trial name
- NCT05489549
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Diabetic Foot Ulcer
Online Diabetic Foot Support Program- Care Kit
The aim of this project is to examine the effects of the online diabetic foot support program (DiaFootSuP) and care kit applied to type 2 diabetic individuals who have previously had a diabetic foot ulcer on diabetic foot…
- Conditions
- Diabetes Mellitus, Diabetic Foot Ulcer, Diabetic Foot
- Trial name
- DiaFootSuP (NCT06760416)
- Testing
- Nursing Education
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Merve GÃnbaAY
Cubital Tunnel Syndrome
Presence of the Arcade of Struthers on Preoperative Ultrasound
To determine the correlation between the presence of the arcade of Struthers on preoperative ultrasound and during endoscopic surgery for cubital tunnel syndrome, and to determine the reliability of a portable ultrasound probe to…
- Trial name
- NCT04658511
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Christine M. Kleinert Institute for Hand and Microsurgery
Diabetic Foot Ulcer, Vitamin D Deficiency
High-Dose Vitamin D3 for Diabetic Foot Ulcer Healing: Randomized Controlled Trial
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effectiveness of high-dose vitamin D3 supplementation in improving diabetic foot ulcer (DFU) healing.
- Conditions
- Diabetic Foot Ulcer, Vitamin D Deficiency, Wound Healing Disorder
- Trial name
- DFU (NCT07139964)
- Testing
- Vitamin D3
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Universitas Sriwijaya
Femoral Nerve Disease
Femoral Nerve Block: Anatomical Insertion Point - A Prospective Randomised Double-Blind Controlled Trial
Nerve blocks are an effective way to control pain after surgery. There are two major nerves that provide sensation to the knee: the femoral nerve provides sensation to the front of the knee and sciatic nerve provides sensation to…
- Trial name
- FNB (NCT00732706)
- Testing
- Sartorius Muscle Twitch, Quadriceps Muscle Twitch
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Pain, Opioid Use
Chronic Pain, Opioid Use, and Epidermal Nerve Fiber Density
This pilot study is being performed to examine whether epidermal axons are altered in patients taking opioid therapy for chronic non-cancer pain, and if epidermal axonal changes predict heightened pain sensitivity.
- Conditions
- Chronic Pain, Opioid Use, Nerve Disorders
- Trial name
- COED (NCT04801498)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Diabetic Foot Ulcer of Neuropathic Origin
The TRAfermin in Neuropathic Diabetic Foot Ulcer Study - Southern Europe The TRANS-South Study
Trafermin is a recombinant human basic fibroblast growth factor (bFGF; original development code, KCB-1), which is manufactured by genetic engineering using Escherichia coli by Kaken Pharmaceutical Co., Ltd. (Tokyo, Japan).
- Trial name
- TRANS-South (NCT01217463)
- Testing
- Trafermin 0.01% spray
- Where
- 24 sites in Czechia, France and 2 more
- Volunteers
- 201 people
- Sponsor
- Olympus Biotech Corporation
Breast Cancer Female, Chemotherapy-induced Peripheral Neuropathy
Home-Based Physical Activity Intervention for Taxane-Induced CIPN
This two-group, randomized control trial (RCT) will test the effects of a home-based, 16 week gait/balance training plus resistance (exercise bands) exercise program as compared to an educational cancer survivorship attention…
- Conditions
- Breast Cancer Female, Chemotherapy-induced Peripheral Neuropathy, Gait Disorders, Neurologic, Balance; Distorted
- Trial name
- B-HAPI (NCT04621721)
- Testing
- Gait/balance & resistive exercise
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- University of South Florida
Breast Cancer, Painful Neuropathy
The Effect of an Inter-Disciplinary Program, Including MBSR, in Breast Cancer Survivors With Chronic Neuropathic Pain
Chronic neuropathic pain is a common problem for breast cancer survivors. Even with the best medical treatment, some survivors continue to experience disabling pain.
- Conditions
- Breast Cancer, Painful Neuropathy, Chronic Pain, Worries; Pain or Disability
- Trial name
- InDepth (NCT02125006)
- Testing
- Mindfulness-Based Stress Reduction
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Limb-Threatening Ischemia, Diabetic Foot
Observational Study Regarding the Necessity of Inclusion of Foot Arch State Together With the Angiosome Theory Within the Wound, Ischemia and Foot Infection Classification (WIfI) to Enhance the Predictability of Wound Healing and Decision Making
This study aims to assess the complete healing or healing progress of foot ulcer within 1 year Where the patients will be classified according to foot arch state together with the angiosome theory and the WIFI clinical stage to…
- Conditions
- Chronic Limb-Threatening Ischemia, Diabetic Foot, Vascular Diseases
- Trial name
- NCT06542523
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetic Neuropathy
Effects of a Homeopathic Anti-inflammatory Topical Cream on Ulcers and Neuropathy in the Diabetic Foot
This is a study whose primary objective is to assess the effectiveness of Neuropathy/Ulcer Cream in the promotion of healing skin fissures plantar foot ulcers and as a moisturizer to prevent dry skin turning into ulcers as…
- Trial name
- NCT01951859
- Testing
- Neuropathy/Ulcer Homeopathic topical cream
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Calvary Hospital, Bronx, NY
Cancer, Chemotherapy-induced Peripheral Neuropathy
Chemotherapy-induced Peripheral Neuropathy (CIPN) on Motor and Sensory Function
As cancer survival rates have been increased due to technological developments and early detection strategies, there has been been a growing need to assess the effect of long-term complications and adverse effects upon patients'…
- Conditions
- Cancer, Chemotherapy-induced Peripheral Neuropathy, Chemotherapeutic Toxicity, Breast Cancer
- Trial name
- NCT04799080
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Izmir Bakircay University
Piriformis Syndrome
Comparative Effects of Post Facilitation Stretch and Active Release Technique in Female Patients With Piriformis Syndrome.
This clinical study aimed to compare the effectiveness of Post-Facilitation Stretch (PFS) and Active Release Technique (ART) on pain, disability, quality of life, and range of motion of hip internal and external rotation in…
- Trial name
- NCT07547059
- Testing
- Post Facilitation Stretch, Active Release Technique
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ibadat International University, Islamabad
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