Clinical trials: Neuropathy (Disorder)
Carpal Tunnel Syndrome
Is Ultrasound-Guided Steroid Injection Less Effective in Carpal Tunnel Syndrome Patients with Bifid Median Nerve?
The aim of this study is to evaluate the short-term efficacy of ultrasound-guided corticosteroid injection in patients with and without bifid median nerve.
- Trial name
- NCT06657612
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Beylikduzu State Hospital
Propionic/Methylmalonic Acidemias, Maple Syrup Urine Disease
Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan
Inborn errors of metabolism (IEM) are not have specific clinical signs, they masquerade as other diseases, and are difficult to diagnose using only clinical manifestations or routine laboratory tests.
- Conditions
- Propionic/Methylmalonic Acidemias, Maple Syrup Urine Disease, Citrullinemia, Argininosuccinic Aciduria
- Trial name
- NCT05910151
- Testing
- Obtaining Dry Blood Spots From Healthy Newborns (Aged 1-7 Days), Obtaining Dry Blood Spots From Healthy Children Aged 8 Days - 7 Years, Obtaining Dry Blood Spots From Healthy Children Aged 8-18 Years
- Where
- Kazakhstan
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Medical University
Diabete Type 2, Diabetic Foot
Prevalence of the Appearance of Diabetic Ulcers in Patients With 3D Insole and LSCI.
Diabetes is a serious and chronic disease that affects more than 347 million people in the world. It is the leading cause of death by age and its prevalence is increasing annually throughout the world.
- Conditions
- Diabete Type 2, Diabetic Foot, Neuropathy, Diabetic, Vascular Disease, Peripheral
- Trial name
- MYFOOT-C (NCT05843929)
- Testing
- LSCI
- Volunteers
- 86 people
- Sponsor
- Esther Soler
Diabetic Neuropathy Peripheral
Nicotinamide Riboside for Diabetic Neuropathy
At the current time there is no effective disease modifying therapy for diabetic neuropathy (DN). The proposed study design employs a quantifiable early measure of DN, intraepidermal nerve fiber density (IENFD), allowing for…
- Trial name
- NiRiD (NCT03685253)
- Testing
- Niagen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Solid Tumors, Breast Cancer
A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer
This is a phase I/II clinical research study with BGT226, an inhibitor of phosphatidylinositol 3'-kinase (PI3K). The study consists of a Phase I dose escalation part followed by a safety expansion part and a Phase II expansion…
- Conditions
- Solid Tumors, Breast Cancer, Cowden Syndrome
- Trial name
- NCT00600275
- Testing
- BGT226
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Foot Ulcers
Randomized, Controlled Multicenter Trial of Vacuum Assisted Closure Therapy™ in Diabetic Foot Ulcers
To determine if topical negative pressure therapy delivered by the V.A.C.® device is clinically efficacious and cost effective in the treatment of diabetic foot ulcers.
- Trial name
- NCT00432965
- Testing
- Moist Wound Therapy, VAC Therapy
- Where
- 25 sites in United States, Canada
- Volunteers
- 335 people
- Sponsor
- KCI USA, Inc
Diabetic Foot Ulcer, Offloading
Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study
Diabetic foot ulceration (DFU) is a common and largely preventable complication of diabetes. While most of these ulcers can be treated successfully, some will persist and become infected.
- Trial name
- NCT02783066
- Testing
- Offloading boot: PulseFlow
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Baylor College of Medicine
Cardiac Amyloidosis
Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis
The primary aim of our pilot study is to determine whether fibrosis in the heart can be measured with [68Ga]CBP8, a positron emission tomography (PET) probe, using PET/magnetic resonance imaging (MRI) imaging, in 30 individuals…
- Trial name
- NCT05619302
- Testing
- [68Ga]CBP8 PET/MRI
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy, Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy
Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)
This study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of NTLA-2001 in participants with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) and…
- Conditions
- Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy, Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy, Wild-Type Transthyretin Cardiac Amyloidosis
- Trial name
- NCT04601051
- Testing
- NTLA-2001
- Where
- 4 sites in France, New Zealand and 2 more
- Volunteers
- 72 people
- Sponsor
- Intellia Therapeutics
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072001
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Carpal Tunnel Syndrome
Reliability And Validity Of Urdu Version Of Boston Carpal Tunnel Syndrome Questionnaire
Translate and culturally adapt Boston Carpal Tunnel Syndrome Questionnaire into Urdu language and find its reliability and validity in Pakistani Carpal Tunnel Syndrome patients To check its correlation with Disabilities of the…
- Trial name
- NCT05207566
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Riphah International University
Wound Infection, Wound Heal
Analytical Performance of pH, HNE and MPO Levels in Detecting Wound Infection Proof of Concept Biomarker Study
The purpose of this study is to evaluate the effectiveness of a novel combination of biomarkers, pH/HNE/MPO, in detecting wound infection using the clinical judgement at 4 weeks as a standard of reference which will include a…
- Trial name
- INDICATE (NCT04979637)
- Sponsor
- ConvaTec Inc.
Carpal Tunnel Syndrome
The Effect of High-intensity Laser Therapy in Patients With Carpal Tunnel Syndrome.
The aim of this study is to evaluate the effects of high intensity laser therapy (HILT) on pain, functional status, hand grip strength and median nerve cross-sectional area in ultrasonography in patients with carpal tunnel…
- Trial name
- NCT05678595
- Testing
- high-intensity laser therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Arrythmia, Cardiac Amyloidosis
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders
The overall aim of this study is to improve our understanding of the effects of the build-up of amyloid deposits in the heart, in particular, our understanding of the risk of abnormal heart beats, or rhythms, associated with…
- Conditions
- Arrythmia, Cardiac Amyloidosis, Sudden Cardiac Death
- Trial name
- EXCALIBUR (NCT04856267)
- Testing
- LINQ device - implantable cardiac monitor - referred to in the application as "implantable loop recorder" or "ILR")
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Marianna Fontana
Diabetic Polyneuropathy
Effect of Transcranial Direct Current Stimulation on Sensory Integration
To determine the effect of Transcranial direct current stimulation on sensory integration and risk of falling in diabetic polyneuropathy.
- Trial name
- NCT04516200
- Testing
- transcranial direct current stimulation and traditional physical therapy program, designed physical therapy program
- Volunteers
- 30 people
- Sponsor
- MTI University
Pediatric Cancer, Pediatric Brain Tumor
Playful Sensorimotor Training in Pediatric Brain Tumor Patients
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and clinically relevant side-effect of cancer treatment.
- Conditions
- Pediatric Cancer, Pediatric Brain Tumor, Chemotherapy-induced Peripheral Neuropathy, Sensorimotor Polyneuropathy
- Trial name
- RESET (NCT03334162)
- Testing
- Sensorimotor training
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Basel
Chemotherapy-induced Peripheral Neuropathy
Role of Curcumin in Paclitaxel Induced PN
Paclitaxel induced peripheral neuropathy is the most common and serious side effect associated with Paclitaxel treatment in breast cancer patients receiving Paclitaxel.
- Trial name
- NCT05966441
- Testing
- Curcumin, Paclitaxel
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Sciatica
A Registry Study of Shujinjianyao Pill Used in Clinical Real World
The purpose of this study is to get to know how Shujinjianyao Pill in hospital results in drug-induced liver injury or other adverse drug reactions from a cohort event monitoring as registration research.
- Trial name
- NCT03598153
- Testing
- Shujinjianyao Pill
- Volunteers
- 3,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Low Back Pain, Sciatica
Ultrasound-guided Lumbar Periradicular Injection: a Non Irradiating Infiltration Technique
We propose here to evaluate the precision of lumbar periradicular infiltration performed under a transverse ultrasound approach by performing a fluoroscopic control once the needle in the desired position.
- Conditions
- Low Back Pain, Sciatica, Disc, Herniated, Foraminal Hernia
- Trial name
- NCT03453775
- Testing
- Ultrasound guided periradicular lumbar infiltration, Fluoroscopy guided periradicular lumbar infiltration
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Libre de Bruxelles
Piriformis Syndrome
f-ESWT vs Steroid Injection for Piriformis Syndrome
This study aims to compare two treatment methods for piriformis syndrome, a condition that can cause pain in the buttock and leg. Adult patients with piriformis syndrome will take part in the trial.
- Trial name
- NCT07145554
- Testing
- Focal extracorporeal schock wave therapy, Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gulhane Training and Research Hospital
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