Clinical trials: Neuropathy (Disorder)
Diabetic Neuropathic Foot Ulcers
CHF6467 SAD and MAD in Patients With Diabetic Foot Ulcer
To assess the safety and tolerability of single and multiple days' topical dosing with CHF6467 in subjects with diabetic foot ulcer (DFU).
- Trial name
- NCT04077671
- Testing
- CHF6467 active
- Where
- Bulgaria
- Volunteers
- 93 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Direct Acting Anticoagulant Adverse Reaction, Needle Injury
Ultrasound Evaluation of Hematoma Risk After Needle EMG in Patient on DOAC Therapy
Approximately 30 minutes after needle EMG, patients who are taking direct oral anticoagulants (DOACs) will undergo an ultrasound examination to evaluate for the presence of possible intramuscular hematomas at the muscles where…
- Conditions
- Direct Acting Anticoagulant Adverse Reaction, Needle Injury, EMG, Peripheral Neuropathies
- Trial name
- U-HAND (NCT07166302)
- Where
- 2 sites in Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Diabetic Foot Ulcer
Use of Remote Thermovisual Monitoring in Patients With a Previous Diabetic Foot Ulcer
The goal of the clinical trial is to investigate adherence to, and effects of, the Bluedrop Monitoring System (BMS) in high-risk patients with at least one previous diabetic foot ulcer (DFU).
- Trial name
- NCT05039645
- Testing
- Patient specific, clinician determined Intervention
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 31 people
- Sponsor
- Bluedrop Medical Limited
Peripheral Neuropathy
Clinical Trial of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical research study is to learn if one acupuncture treatment approach is more effective than another in helping to relieve chemo-therapy induced neuropathy in cancer patients.
- Trial name
- NCT03881748
- Testing
- Manual acupuncture, Electro-acupuncture
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Diabetic Foot Ulcer, Deep Diabetic Foot Ulcer
Comparative Effectiveness of Two Acellular Matrices (Dermacell vs. Integra) for Management of Deep Diabetic Foot Ulcers
Diabetes-related foot ulcers (DFUs) are a leading cause of hospitalization and amputation worldwide, and account for 33% of all direct costs of diabetes care in the US.
- Trial name
- NCT03476876
- Testing
- Dermacell, Integra
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Baylor College of Medicine
Hammer Toe Syndrome, Foot Ulcer, Diabetic
Flexor Tenotomy and Ulcer Recurrence
The main purpose of this study is to assess the efficacy of flexor tenotomy on the prevention of recurrence of toe ulcers in people with diabetes and a history of toe ulceration.
- Trial name
- NCT05228340
- Testing
- Flexor tenotomy
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetic Polyneuropathy
Peripheral Nerve Stimulation in Diabetic Patients
The prevalence of diabetes mellitus (DM) in industrialized countries is estimated to be about 7.3% and its incidence has been growing in recent years.
- Trial name
- NCT01488474
- Testing
- peripheral nerve stimulation
- Where
- Austria
- Volunteers
- 124 people
- Sponsor
- Medical University of Graz
Carpal Tunnel Syndromes
The Role of the Cervical Spine in Carpal Tunnel Syndrome
This randomized clinical trial will investigate changes in hand function, active cervical range of motion and pinch grip force after the application of physical therapy in women with carpal tunnel syndrome (CTS).
- Trial name
- NCT02233660
- Testing
- Physical Therapy Group, Surgical Group
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Rey Juan Carlos
Carpal Tunnel Syndrome
Flexor Tenosynovectomy to Treat Recurrent Carpal Tunnel Syndrome
The purpose of this study is to collect data on the clinical and functional outcomes of surgical management for recurrent carpal tunnel syndrome (CTS) using flexor tenosynovectomy.
- Trial name
- NCT03757416
- Testing
- Data collection
- Volunteers
- 2 people
- Sponsor
- University of Tennessee
Diabetes Complications, Diabetes Education
Impact of an Educational Intervention on Ulcer Incidence, Knowledge, Self-Care, and Quality of Life in Diabetic Foot Syndrome
This randomized clinical trial assessed the impact of a structured educational intervention in patients with diabetic foot syndrome.
- Conditions
- Diabetes Complications, Diabetes Education, Diabetes Foot Care
- Trial name
- NCT07329491
- Testing
- Structured education intervention, Standard podiatry care
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Universidad Complutense de Madrid
Peripheral Neuropathy
Venlafaxine in Preventing Chronic Oxaliplatin-Induced Neuropathy In Patients Receiving Combination Chemotherapy
You are being asked to take part in this research study because you are going to be treated with oxaliplatin chemotherapy as part of your standard care.
- Trial name
- NCT01611155
- Testing
- venlafaxine, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Carpal Tunnel Syndrome (CTS)
The Effectiveness of Pain Neuroscience Education for Patients With Carpal Tunnel Syndrome
The goal of this clinical trial is to investigate the effects of Pain Neuroscience Education applied in the treatment of mild and moderate carpal tunnel syndrome (CTS).
- Trial name
- NCT07302282
- Testing
- Exercise, Pain neuroscience education
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Karamanoğlu Mehmetbey University
Carpal Tunnel Syndrome
Evaluation of the MANOS Carpal Tunnel Release System in Patients With Carpal Tunnel Syndrome
The MANOS device is a carpal tunnel blade used to perform carpal tunnel release (CTR). CTR is indicated for the treatment of Carpal Tunnel Syndrome when conservative therapy fails.
- Trial name
- NCT01450735
- Testing
- MANOS CTR™
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Thayer Intellectual Property, Inc.
Chemotherapy-induced Peripheral Neuropathy
Neural and Immune Correlates of CIPN and Possible Analgesic Effect of Non-invasive Motor Cortex Stimulation
Over half of cancer patients receiving common chemotherapy treatments experience painful nerve damage called chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NIBS4CIPN (NCT06522685)
- Testing
- transcranial direct current stimulation Soterix REMOTE 1x1 miniCT
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Morgan State University
Leber Hereditary Optic Neuropathy
Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year
The goal of this clinical trial is to assess the efficacy and safety of GS010 gene therapy - (lenadogene nolparvovec) in subjects with LHON due to the G11778A ND4 mitochondrial mutation with a vision loss up to one year.
- Trial name
- REFLECT (NCT03293524)
- Testing
- GS010
- Where
- 13 sites in United States, Belgium and 5 more
- Volunteers
- 98 people
- Sponsor
- GenSight Biologics
Chronic Wound, Burn Wound
Wound Healing Endpoint and Recurrence
This study is a continuation of a previously approved protocol conducted at Ohio State University and Indiana University. The first two aims of the original protocol have been completed, and this protocol will finish enrollment…
- Conditions
- Chronic Wound, Burn Wound, Diabetic Foot Ulcers, Pressure Ulcers
- Trial name
- NCT02577120
- Testing
- Epiceram Skin Barrier Function, Vaseline Petroleum Jelly
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sashwati Roy
Lumbar Disc Herniation, Lumbar Radiculopathy
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back.
- Conditions
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- Trial name
- SELDISC (NCT07895589)
- Testing
- Selective Nerve Root Block
- Where
- 2 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Karolinska Institutet
Diabetes, PAD
Micro-mobile Foot Compression and Diabetic Foot
Diabetic foot ulceration (DFU) is a common and largely preventable complication. While most of these ulcers can be treated successfully, some will persist and become infected.
- Conditions
- Diabetes, PAD, Lower Extremity Edema, Neuropathy;Peripheral
- Trial name
- NCT03135535
- Testing
- Avex Footbeat
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Diabetic Foot Ulcer
Bioactive Smart Dressings for Diabetic Foot Ulcers: Randomized Controlled Trial
We propose a randomized controlled study to assess the efficacy of: 1. Platelet-lysate loaded sustained release thermo-gelling formulation (Platelets-SR) 2.
- Trial name
- NCT05671250
- Testing
- PRP gel and SOC-treatment, EPO/ISDN/UFH cryogel dressing, Standard of Care
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Diabetic Foot Ulcer, Diabetic Foot
Quality of Life and Self-care in Patients With Diabetic Foot Ulcers Treated With Low-level Laser Therapy
Diabetic foot ulcers (DFU) are aggressive complications of diabetes mellitus (DM) and affect 25% of these patients. DFU are associated with a high risk of amputations and early mortality and significantly impact quality of life…
- Trial name
- NCT05071235
- Testing
- LG1 (LLLT group 1), LG2 (LLLT group 2), LG3 (LLLT group 3)
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of Piaui
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