Clinical trials: Neuropathy Demyelinating
Multiple Sclerosis, Foot Drop
Walking With FES or AFO in People With MS With Foot Drop
This investigation consists of two parallel groups of participants who will follow the same protocol. The aim of the study is to investigate the effects of using Functional Electrical Stimulation/Ankle Foot Orthosis (AFO) or…
- Trial name
- NCT01977287
- Testing
- Functional Electrical Stimulation, Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen Margaret University
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy
OBJECTIVES: I. Compare and evaluate the response to treatment with intravenous human immune globulin (IVIG) or placebo in previously untreated patients with chronic inflammatory demyelinating polyneuropathy.
- Trial name
- NCT00004286
- Testing
- immune globulin
- Volunteers
- 120 people
- Sponsor
- National Center for Research Resources (NCRR)
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Ripertamab for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy
The goal of this clinical trial is to learn if ripertamab works to treat chronic inflammatory demyelinating polyneuropathy. It will also learn about the safety of ripertamab.
- Trial name
- RIPERT-CIDP (NCT06858722)
- Testing
- ripertamab
- Volunteers
- 175 people
- Sponsor
- Zhongming Qiu
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), CIDP
Pre-Approval Access for Efgartigimod PH20 SC in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
The aim of the Pre-Approval Access program is to provide efgartigimod PH20 SC treatment to patients with CIDP who are ineligible to participate in a clinical study and have unmet medical need despite available treatment options.
- Trial name
- NCT04777734
- Testing
- Efgartigimod PH20 SC
- Sponsor
- argenx
Chronic Inflammatory Demyelinating Polyneuropathy
Rituximab in Chronic Inflammatory Demyelinating Polyneuropathy
CIDP is a heterogeneous disease with variable responses to therapy. Recently, a distinctive subgroup of patients with serum autoantibodies to the paranodal proteins contactin and neurofascin have been identified.
- Trial name
- NCT04480450
- Testing
- Rituximab
- Sponsor
- University of Kansas Medical Center
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
Multimodal Characterization of Movement Trajectories in Chronic Inflammatory Demyelinating Polyneuropathy
This prospective, longitudinal study aims to evaluate the usefulness of high-resolution whole-body motion data captured by wearable sensors to assess functional status and longitudinal changes in CIDP (chronic inflammatory…
- Trial name
- MOVE CIDP (NCT07882797)
- Testing
- Xsens motion suit
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Efficacy and Safety Study of I10E in Treatment of Patients With CIDP
Primary objective: To assess the efficacy of I10E in improving the disability of patients with CIDP. Secondary objective: To assess the safety of I10E in patients with CIDP.
- Trial name
- PRISM (NCT02293460)
- Testing
- I10E
- Where
- 33 sites in France, Italy and 4 more
- Volunteers
- 44 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Chronic Inflammatory Demyelinating Polyneuropathy
Safety, Tolerability, and Efficacy of NVG-2089 in Participants With CIDP
The purpose of the study is to evaluate the safety of NVG-2089 and to evaluate how well patients respond to this investigational treatment. NVG-2089 is a new drug that is being developed for treating patients with CIDP.
- Trial name
- INVGOR (NCT07027111)
- Testing
- NVG-2089
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nuvig Therapeutics, Inc.
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Clinical Trial to Assess the Safety of a Novel Scaffold Biomaterial
This is safety study. Subjects will be undergoing the surgical procedure of nerve biopsy. After routine surgery without grafting, patients develop swelling, redness, tenderness and dysesthesia at the biopsy site.
- Conditions
- Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Vasculitic Neuropathy (Disorder), Amyloidosis
- Trial name
- NCT03584022
- Testing
- Biopsy + Nerve Repair, Biopsy Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chronic Inflammatory Demyelinating Polyneuropathy, Charcot-Marie-Tooth Disease, Type IA
Quantification of Nerve Stiffness in Neuropathies
This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography.
- Conditions
- Chronic Inflammatory Demyelinating Polyneuropathy, Charcot-Marie-Tooth Disease, Type IA, Anti-MAG Neuropathy
- Trial name
- Nerf_SSI (NCT03397303)
- Testing
- elastography measurements
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Pediatric Chronic Inflammatory Demyelinating Polyneuropathy
Study to Evaluate Safety and Efficacy of Different PANZYGA Dose Regimens in Pediatric Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Patients
Safety and Efficacy of Different PANZYGA Dose Regimens in Pediatric Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Patients
- Trial name
- NCT04929236
- Testing
- Panzyga
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Octapharma
Chronic Inflammatory Demyelinating Polyneuropathy
High-dose Cyclophosphamide for Moderate to Severe Refractory Chronic Inflammatory Demyelinating Polyneuropathy
The primary endpoint of this study is to determine what percentage of patients receiving high-dose Cyclophosphamide may experience a halt in the worsening of their disease or experience improvement of their disease and for how…
- Trial name
- NCT01236456
- Testing
- Cyclophosphamide
- Sponsor
- Stony Brook University
Carpal Tunnel Syndrome, Diabetic Neuropathies
Neuromuscular Ultrasound in Correlation to Neurophysiological Findings
1. Study the neuromuscular ultrasound findings in different types of neuropathies 2. correlation between ultrasound and neurophysiological findings in peripheral nerve diseases 3.
- Conditions
- Carpal Tunnel Syndrome, Diabetic Neuropathies, Guillain-Barre Syndrome
- Trial name
- NCT04092140
- Testing
- ultrasound
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Orthostatic Tremor, Neuropathy
Prevalence of Orthostatic Tremor in Patients With Unsteadiness
Clinical presentation of orthostatic tremor (OT) may be misleading and simply perceived by a postural instability such as in several peripheral neuropathies.
- Trial name
- EMG-SOT (NCT04844203)
- Testing
- Polygraphy with surface electrodes
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Evaluation of the Diagnostic Contributions of Nerve Ultrasound in Chronic Inflammatory Demyelinating Polyneuropathy Associating Systemic Diseases (CIDP Echo-nerf)
Chronic inflammatory demyelinating polyradiculoneuritis (CIDP) is an autoimmune disorder of the peripheral nervous system, most commonly affecting the myelin sheath.
- Trial name
- CIDP echo-nerf (NCT05257733)
- Testing
- None, pure observationnal study
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Inflammatory Demyelinating Polyneuropathy
An Expanded Access IND for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This is an Individual Patient Expanded Access IND to evaluate the safety and preliminary efficacy of autologous HB-adMSCs for treating a single patient Chronic Inflammatory Demyelinating Polyneuropathy, CIDP.
- Trial name
- NCT04825626
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Comparison of FEETME® Soles and GAITRITE® Walkway for the Evaluation of Gait Disorders in CIDP.
Chronic Inflammatory Demyelinating Polyneuropathies (CIDP) are acquired, autoimmune and inflammatory neuropathies leading mainly to gait disorders in patients.
- Trial name
- ESCAL-PIDC (NCT05492604)
- Testing
- Clinical examination, Functional scales, Walking test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux