Clinical trials: Neurophysiologic Monitoring
Intraoperative Neurophysiological Monitoring, Malignant Brain Tumors
Intraoperative Neurophysiological Monitoring in Brain Tumor Surgery: Prospective Cohort Studies
BACKGROUND Brain tumor surgery requires balancing two competing priorities: maximizing the extent of tumor resection to improve survival while preserving neurological function.
- Conditions
- Intraoperative Neurophysiological Monitoring, Malignant Brain Tumors, Motor Evoked Potential Monitoring, Cortico-cortical Evoked Potential Monitoring
- Trial name
- NCT07789938
- Testing
- Intraoperative neurophysiological monitoring, no Intraoperative neurophysiological monitoring
- Where
- Denmark
- Volunteers
- 166 people
- Sponsor
- Odense University Hospital
Anesthesia and Analgesia, Laparoscopic Surgical Procedure
Record and Analyze the Data of Patient Undergoing Anesthesia for Laparoscopic Cholecystectomy From Patient Monitoring Instruments
To record the digital data from monitoring instruments (standard patient monitor) containing cardiovascular system information, and from depth-of-anesthesia monitoring modules (Bispectral index, Entropy module, Surgical…
- Conditions
- Anesthesia and Analgesia, Laparoscopic Surgical Procedure, Monitoring, Physiologic, Hemodynamic Monitoring
- Trial name
- NCT03691103
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Neurologic Disorder
Comparison of Remimazolam and Propofol Combination vs. Propofol in IOM
This study aims to compare total intravenous anesthetic agents: combined remimazolam and propofol vs. propofol monotherapy. The comparison parameters are intraoperative hypotension, patient's involuntary movement…
- Trial name
- NCT06382467
- Testing
- Remimazolam besylate + propofol MCT, Propofol MCT
- Volunteers
- 56 people
- Sponsor
- Chung-Ang University Gwangmyeong Hospital
Brain Tumor Adult, Epilepsy
WISE Cortical Strip for Intraoperative Neurophysiological Monitoring
The WIN Study is a prospective, interventional, multi-center, open-label premarket study designed to confirm the safety, performance and intended use of the WISE Cortical Strip (WCS) for CE certification purposes.
- Trial name
- WIN (NCT03731455)
- Testing
- WISE Cortical Strip
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 32 people
- Sponsor
- Wise S.r.l.
Idiopathic Scoliosis
Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients
When patients have spinal surgery, electrodes are placed on the body to measure motor evoked potentials (MEP) and somatosensory evoked potentials (SSEP).
- Trial name
- NCT01549873
- Testing
- propofol, Desflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nationwide Children's Hospital
BIS
Pediatric Frontal and Nasal Bispectral Index
To compare the accuracy of frontal versus nasal BIS monitoring in pediatric patients under general anesthesia.
- Trial name
- NCT06255236
- Testing
- Bispectral index (BIS)
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Intraoperative Neurophysiological Monitoring
Effect of Perioperative Factors on the Analgesia Nociception Index
The Analgesia Nociception Index (ANI) is a new unitless marker derived from Heart Rate Variability spectral analysis, ranging between 0 and 100 and expressing the parasympathetic tone.
- Trial name
- ANIFACT (NCT02305576)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Monitoring, Postoperative
Evaluating Monitoring Techniques for Postoperative Spinal Cord Ischemia
During open surgery of a thoraco-abdominal aortic aneurysma (TAAA), diminished blood flow to the myelum can result in hypoxia, compromising proper function of the spinal cord.
- Conditions
- Monitoring, Postoperative, Spinal Cord Ischemia, Thoracoabdominal Aneurysm
- Trial name
- SINATRA (NCT03074487)
- Testing
- Near-infrared spectroscopy, Long loop reflex measurements
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Intraoperative Neurophysiological Monitoring, Magnesium Sulfate
Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring
Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to…
- Trial name
- NCT04938765
- Testing
- Magnesium sulfate, Normal Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Epilepsy, Temporal Lobe
The Utility of NIOM During LITT for Refractory MTLE
Mesial temporal lobe epilepsy (MTLE) is the most common cause of medication-resistant epilepsy in adults, and MRI-guided laser interstitial thermal therapy is a new approach to its surgical management; however, while LITT…
- Trial name
- NCT02913742
- Testing
- monitoring by depth electrode
- Where
- United States
- Sponsor
- Duke University
Vestibular Schwannoma, Facial Nerve Paralysis
Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients
The purpose of this study is to evaluate the efficacy and safety of steroids treatment compared with placebo in preserving facial nerve function after craniotomy in patients with vestibular schwannoma who have not received…
- Trial name
- SAF-NRVS (NCT07116811)
- Testing
- Steroids therapy
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Beijing Tiantan Hospital
Spinal Cord Neoplasms, Spinal Neoplasms
Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery
Intraoperative neurophysiological monitoring (IONM) using motor evoked potentials (MEP) and somatosensory evoked potentials (SEP) is routinely applied during spinal tumor resection to detect impending neurological injury.
- Trial name
- NCT07901504
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Cardiac Disease, Cognitive Dysfunction
Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS)
Neurological dysfunction continues to be one of the complications of considerable concern in patients undergoing cardiac surgery.
- Trial name
- COSMICS (NCT04766554)
- Testing
- Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter) and protocol-based interventions
- Where
- 2 sites in Brazil
- Volunteers
- 326 people
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Intraoperative Neurophysiological Monitoring
MINDZ-- Minimally Invasive Approach Pilot Study
This clinical investigation is a pilot, first-in-human (FIH) study designed to demonstrate proof of concept, safety, and functional performance of the MINDZ subdural electrode grid when used in relevant neurosurgical settings.
- Trial name
- MINDZ-MAP (NCT07543406)
- Testing
- MINDZ Subdural Electrode Grid
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- Neurosoft Bioelectronics SA
Spinal Stenosis, Lumbar Region, With Neurogenic Claudication
Clinical Effectiveness, Security And Radiological Changes In Epiduroscopy For Lumbar Stenosis
It will be done a prospective Study involving 38 patients with lumbar stenosis. A magnetic resonance (MR) imaging study and a electromyographic study will be done previously and 3 months after the epiduroscopy to confirm…
- Trial name
- NCT03863067
- Testing
- Epiduroscopy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Major Depressive Disorder
Neurophysiologic Monitoring of Antidepressant Treatment
The overall goal of this proposal is to study quantitative electroencephalography (QEEG ) as a method for the detection of antidepressant treatment response.
- Trial name
- Lilly (NCT01360190)
- Testing
- fluoxetine
- Volunteers
- 24 people
- Sponsor
- University of California, Los Angeles
Brainstem Lesion, Surgery
Data Collection and Analysis in Brainstem Surgeries
The hypothesis is that the structural documentation and analysis of the data of demographics, neuroimaging, IONM and clinical outcomes can help to further standardize the use of such equipment for detecting the integrity of the…
- Conditions
- Brainstem Lesion, Surgery, Intraoperative Neurophysiologic Monitoring
- Trial name
- NCT04707053
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Cantonal Hospital of St. Gallen
Anesthesia, Pain
Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia
The aim of this prospective randomized study is to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in pediatric anesthesia.
- Conditions
- Anesthesia, Pain, Child
- Trial name
- NCT02683837
- Testing
- Remifentanil, Pupillometry, Sevoflurane
- Where
- Switzerland
- Sponsor
- University Hospital, Geneva
Spinal Disease, Anesthesia
Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds
The purpose of this study is to determine the effect of lidocaine infusion on intraoperative neuromonitoring in patients undergoing spine surgery.
- Conditions
- Spinal Disease, Anesthesia, Post Operative Pain
- Trial name
- NCT06792474
- Testing
- Lidocaine in Saline, Normal saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center