Clinical trials: Neurophysiology
Depression
Effects of Aerobic Exercise Modulation on Brain Physiology and Cognition in Young Adults With Depression
Major depressive depression (MDD) affects a quarter of young adults and is associated with marked global burden in this population.
- Trial name
- NCT04708691
- Testing
- Aerobic exercise
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Young Healthy Adults (no Medical Condition/Disease)
Creatine and Motor Skill Acquisition
The investigators will conduct a double-blind, placebo-controlled, repeated measures study of the effects of oral creatine monohydrate supplementation on motor skill acquisition and neurophysiology in young healthy adults.
- Trial name
- NCT05201651
- Testing
- Creatine Monohydrate
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Regina
Aging
Development of Clinical Methods to Evaluate Neural Function in Aging
A primary focus of the University of Florida (UF) Claude D. Pepper Older Americans Independence Center (OAIC) is to build a comprehensive understanding of the causes and consequences of declining physical function and disability…
- Trial name
- MIND (NCT02073201)
- Testing
- High-functioning older adults, Lower-functioning older adults, Young adults
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Florida
L-theanine
Theanine and Caffeine on Neurophysiology of Attention
L-theanine and caffeine are nutritional compounds that are naturally found in tea. Our recent findings using an EEG paradigm are consistent with the findings of others, indicating that intake of L-theanine and caffeine reduce the…
- Trial name
- THECNA (NCT02770105)
- Testing
- Theanine, Caffeine, Theanine-Caffeine Combination
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Tourette Syndrome, Tic Disorder
Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder
Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population.
- Trial name
- NCT06576726
- Testing
- This study involves no intervention.
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
PTSD
Novel EEG Coherence Biomarkers for PTSD Assessment
Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report.
- Trial name
- NCT04209387
- Testing
- Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD ( ACT-SS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, Demyelinating Disease
Neurophysiological Assessment in Patients With Multiple Sclerosis
Main aim of this study will be the evaluation of the neurophysiological techniques of Transcranial Magnetic Stimulation (TMS) via electroencephalography (EEG) co-registration (TMS-EEG) with the study of TEPs (TEP: transcranial…
- Conditions
- Multiple Sclerosis, Demyelinating Disease, Inflammatory Disease
- Trial name
- NCT04997343
- Testing
- Neurophysiological assessment, clinical assessment
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
COVID-19 Acute Respiratory Distress Syndrome, Cognitive Decline
Cognitive Functions After COVID-19
This study was aimed to evaluate the post-infection cognitive functions of adult individuals with COVID-19. 50 individuals with COVID-19 and 50 healthy control groups were included in the study.
- Trial name
- NCT04978246
- Testing
- Neuropsychometric Test
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
Migraine
Neurophysiology of Prophylactic Treatment in Migraine
This study aims to improve the pathophysiological understanding of migraine in in a longitudinal observational study investigating changes of established neurophysiological and imaging parameters in line with changes of the…
- Trial name
- NCT04019496
- Testing
- antibodies against calcitonin-gene related peptide or its receptor
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Single Seizure, Epilepsy
Seizure Recurrence After Unprovoked First Seizure
One in 10 people have a seizure during their life. Usually no cause is identified. Seizures without an identified cause are called unprovoked first seizure (UFS). Most people with UFS do not have further seizures.
- Trial name
- NCT05724719
- Where
- 2 sites in Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Dr. Gavin Winston
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy
Trial Investigating the Characteristics of Knismesis - a Lever to Explore Allodynia in Neuropathic Pain
Also known as a "moving itch", knismesis is a mildly annoying sensation caused by a light movement on the skin, such as from a crawling insect. Its underlying mechanism rely on spatial summation, i.e.
- Trial name
- TICKLE (NCT04621747)
- Testing
- Battery of neurophysiological explorations
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diplegia, Spastic
Eye-Hand Coordination in Children With Spastic Diplegia
This study will examine how the brain controls eye-hand coordination (visuomotor skills) in children with spastic diplegia and will determine whether impairment of this skill is related to the learning difficulties in school that…
- Trial name
- NCT00024791
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cancer, Cancer Head Neck
Neuroinflammation in Chronic Systemic Symptoms (CSS)
The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).
- Conditions
- Cancer, Cancer Head Neck, Neuroinflammatory Response, Chronic Inflammation
- Trial name
- NCT04636723
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chronic Low-back Pain (cLBP)
Pain Assessment Through Integrated Neurophysiology and Multidimensional Profiling
This observational case-control study aims to investigate the central neurophysiological mechanisms underlying non-specific chronic low back pain (CLBP) with neural mechanosensitivity, with wearable Optically Pumped Magnetometers…
- Trial name
- PAIN-MAP (NCT07846163)
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Neck Pain, Chronic Pain
Brain, Brainstem, and Spinal Cord fMRI
New advances in medical imaging have allowed for the measurement of brain activity related to chronic pain. In addition to the brain, the investigators aim to use functional magnetic resonance imaging to investigate pain…
- Trial name
- NCT02356315
- Testing
- Functional Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Ankle Injuries
Neurophysiology of Ankle Instability
Chronic ankle instability (CAI) is a common debilitating orthopedic condition that disrupts physical function and decreases quality of life. Not all CAI is the same.
- Trial name
- NCT06576687
- Testing
- Physical Rehabilitation
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Migraine Headache
Autonomic Dysfunction in Patients With Migraine: Cardiovascular and Neurophysiology Assessment
Autonomic dysfunction in patients with migraine: cardiovascular and neurophysiology assessment.
- Trial name
- NCT06798259
- Where
- Egypt
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Surveys and Questionnaires, Child
Development and Clinimetric Properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire in Healthy Children
The scientific objective of this research implies developing and examining the clinimetric properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire (PedNPQ) in healthy children.
- Conditions
- Surveys and Questionnaires, Child, Pain, Knowledge
- Trial name
- NCT03162835
- Testing
- Pain Neuroscience Education
- Where
- Belgium
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital