Clinical trials: Neurophysiology
Human Volunteers
The Effects of a Novel NMDA NR2B-Subtype Selective Antagonist, EVT 101, on Brain Function
The purpose of this study is to investigate the neurophysiological changes following single doses of EVT 101 using fMRI during rest and during cognitive tasks in young healthy male subjects.
- Trial name
- NCT00526968
- Testing
- EVT 101
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Evotec Neurosciences GmbH
Flatfoot, Flexible, Sports Physical Therapy
Neurophysiology-based Intervention of Foot Dysfunction in Sportive Children
The goal of the clinical trial study is to test the effect of the individual complex physiotherapy intervention program in the children actively playing soccer with flatfoot or valgus foot. The aims are: 1.
- Conditions
- Flatfoot, Flexible, Sports Physical Therapy, Child Development
- Trial name
- NCT05902091
- Testing
- Neurophysiology-based intervention
- Where
- Czechia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Knowledge, Attitude
Pain Neurophysiology Education for Sport Therapy Students
The effect of a 70 minute Pain Neurophysiology Education session on Sport Therapy Students Knowledge, Attitudes and Clinical Behaviour Towards Athletes With Chronic Pain
- Conditions
- Knowledge, Attitude, Behavior
- Trial name
- NCT03002181
- Testing
- Education
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Teesside University
Adults With Variability in Their Mood
Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)
Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day
- Trial name
- BandR (NCT07252011)
- Testing
- Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bipolar Disorder
Effects of Quetiapine on Ultrastructural Hippocampal and Neurochemical Changes in Patients With Bipolar Disorder: Searching for Antidepressant and Mood Stabilising Neurophysiology
The aim of the study was to determine the pharmacological induced equivalents of neurogenesis and synaptic sprouting in the hippocampus, localized volume changes, changes in water content and neurochemical changes in the medial…
- Trial name
- NCT01552837
- Testing
- Seroquel
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Musculoskeletal Physiology
Training for Diagnosing Neurological Disorders
This training protocol has two objectives: 1) to train NINDS fellows in specialized techniques for diagnosing neurological disorders, and 2) to gather data from healthy volunteers and from patients with various disorders needed…
- Trial name
- NCT00132353
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Attention Deficit Hyperactivity Disorder (ADHD)
Train Your Brain and Exercise Your Heart? Advancing the Treatment for Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder (ADHD) is a developmental disorder that has a severe impact on a child's life and society. The core symptoms are attention problems, hyperactivity and impulsivity.
- Trial name
- NCT01363544
- Testing
- Neurofeedback, Exercise, methylphenidate
- Where
- 6 sites in Netherlands
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- R. van Mourik
Progressive Supranuclear Palsy
Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy
The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in classical forms.
- Trial name
- Gait-PSP (NCT04096651)
- Testing
- gait recordings, brain magnetic resonance imaging, oculomotor movement recordings
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Healthy
Effects of Perampanel on Neurophysiology Test Perimeters
This is a study to evaluate the effects of perampanel, a FDA approved drug for epilepsy, on commonly performed neurophysiology tests: electroencephalogram (EEG), somatosensory evoked potential (SEP), brainstem auditory evoked…
- Trial name
- NCT03653741
- Testing
- Perampanel 6 MG
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer's Disease
Memory Imaging of Normal Aging
The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.
- Trial name
- NCT00315575
- Testing
- BOLD and Perfusion brain MRI
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Dystonia, Cerebral Palsy
Studying Childhood-Onset Hemidystonia
Background: Childhood-onset dystonia is caused by a brain injury. It causes muscle contractions and twisting movements that the person with dystonia cannot control.
- Trial name
- NCT01432899
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy, Pediatrics
Pediatric Transcranial Static Magnetic Field Stimulation to Improve Motor Learning
Non-invasive brain stimulation (NIBS) is a safe, painless way to improve brain function. It is used for many conditions, including to help children with disabilities.
- Trial name
- PSTIM (NCT03949712)
- Testing
- Transcranial Static Magnetic Field Stimulation (tSMS)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Heart Failure With Normal Ejection Fraction
Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the heart failure population in the United States.
- Trial name
- NCT03465072
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Gait
AB Gait Estim Neurophysiology
This study is being done to answer the question: What are the effects of electrical stimulation and stepping practice on connections between the brain and muscles? The long-term goal of this project is to develop novel…
- Trial name
- NCT06430164
- Testing
- Gait Training, Functional electrical stimulation (FES), Peripheral electrical stimulation paired with cortical magnetic stimulation pulses
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Essential Tremor, Cervical Dystonia
Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor
Background: Essential tremor is when a person has tremor, but no other neurological symptoms. Dystonic tremor is when a person also has dystonia. Dystonia is a condition in which muscle contraction causes changes in posture.
- Conditions
- Essential Tremor, Cervical Dystonia, Focal Dystonia
- Trial name
- NCT03041714
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sleep, Glymphatic System
Sleep and Performance
This research is being done to apply new, contrast-free MRI (Magnetic Resonance Imaging) methods to understand the brain's waste clearance system (the "glymphatic" system) in younger adults.
- Trial name
- MTEC Phase 2 (NCT07608614)
- Testing
- Transcranial Electric Stimulation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Suicidal Depression
Cognition, Sleep, Neurophysiology of Suicidal Depressed Patients
evaluation whether suicidal major depressive disorder patients show a specific pattern of cognitive, sleep and neurophysiologic impairment as compared to non- suicidal major depressive disorder patient, and studying the…
- Trial name
- NCT04813835
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients
Some cancer patients report experiencing mild problems with thinking during or following chemotherapy. Symptoms include problems concentrating, slow thinking, some gaps in memory and difficulty performing complex or multi-tasks.
- Trial name
- NCT02896504
- Testing
- Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Normal Physiology
Neurophysiology of Surround Inhibition in the Human Motor Cortex
Background: Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement.
- Trial name
- NCT03018262
- Testing
- TMS - sub-study 1, TMS - sub-study 2, TMS - sub-study 3
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)