Clinical trials: Neurophysiology
Endometriosis
Therapeutic Exercise and Education in Neurophysiology of Pain in the Quality of Life of Women With Endometriosis
The objective of this study will be to evaluate treatment using ET exercise and pain education in women with endometriosis to achieve improvement in quality of life.
- Trial name
- NCT05679063
- Testing
- Physiotherapy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Valladolid
Sleep, Glymphatic System
Sleep and Performance
This research is being done to apply new, contrast-free MRI (Magnetic Resonance Imaging) methods to understand the brain's waste clearance system (the "glymphatic" system) in younger adults.
- Trial name
- MTEC Phase 2 (NCT07608614)
- Testing
- Transcranial Electric Stimulation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Migraine, Preventive Treatment
Prediction of Migraine Prevention Efficacy Based on Individual's Pain Modulation
A major reason for the substantial underuse of pharmacological prevention of migraine is its inadequate efficacy, since only ~50% of patients respond to a specific agent.
- Trial name
- NCT02101892
- Testing
- Amitriptyline
- Where
- Israel
- Volunteers
- 54 people
- Sponsor
- Rambam Health Care Campus
Oropharyngeal Dysphagia, Dysphagia
Subacute Effect of Pharyngeal Pharmacological Sensory Stimulation in Elderly Patients With Oropharyngeal Dysphagia
Oropharyngeal sensory impairments are a potential target for treatment of oropharyngeal dysphagia (OD) in older patients. We previously found acute administration of TRP sensory stimulants improved VFS signs and swallow response.
- Conditions
- Oropharyngeal Dysphagia, Dysphagia, Swallowing Disorder
- Trial name
- FIS2018 (NCT04741620)
- Testing
- Capsaicin 10microM (TRPV1 natural agonist), Piperine 150microM (TRPV1 & TRPA1 natural agonist), Cinnamaldehyde 756,6microM + zinc 70microM (TRPA1 natural agonist)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital de Mataró
Stroke Ischemic
Effect of Repetitive Transcranial Magnetic Stimulation on Neurological Recovery in Patients With Ischaemic Stroke
The goal of this clinical trial is to learn if transcranial magnetic stimulation(rTMS) can improve neurological rehabilitation in patients with acute ischemic stroke.
- Trial name
- NCT06415734
- Testing
- rTMS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Normal Physiology
Neurophysiology of Surround Inhibition in the Human Motor Cortex
Background: Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement.
- Trial name
- NCT03018262
- Testing
- TMS - sub-study 1, TMS - sub-study 2, TMS - sub-study 3
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acquired Brain Injury, Traumatic Brain Injury
Pilot Trial for Adults With Acquired Brain Injury
This pilot study will compare a yoga program to a non-yoga exercise program in adults with brain injuries. The investigators will measure possible improvements in balance and heartrate.
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Stroke
- Trial name
- RCT (NCT05793827)
- Testing
- Adapted Hatha Yoga, Low-Impact Exercise
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Colorado State University
Chronic Low Back Pain (CLBP)
Pain Neurophysiology Education in Chronic Low Back Pain
The investigators conducted a randomized controlled study including 22 patients suffering from chronic common low back pain. Patients were randomized into 2 groups: Control group received conventional rehabilitation only (11…
- Trial name
- PNE-LBP (NCT06915532)
- Testing
- Pain Neurophysiology Education, conventional rehabilitation
- Where
- Tunisia
- Volunteers
- 22 people
- Sponsor
- Hopital Charles Nicolle
Fear Avoidance
Knowledge, Attitudes, and Beliefs About Musculoskeletal Pain Among Primary Care Health Professionals in Spain.
Pain is influenced by psychological and emotional factors, and healthcare professionals may unintentionally contribute to chronic disability by reinforcing fear and limiting normal activity.
- Trial name
- CACDAPES (NCT06900231)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Universitat de Lleida
Chronic Pain, Opioid Dependence
Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Dependence
Chronic musculoskeletal pain (CMP) is estimated to affect over 100 million adults and is targeted as an instigator of opioid dependence (OpD).
- Trial name
- NCT06442306
- Testing
- Pain Neuroscience Education, General Health Education
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wichita State University
Multiple Sclerosis, Demyelinating Disease
Neurophysiological Assessment in Patients With Multiple Sclerosis
Main aim of this study will be the evaluation of the neurophysiological techniques of Transcranial Magnetic Stimulation (TMS) via electroencephalography (EEG) co-registration (TMS-EEG) with the study of TEPs (TEP: transcranial…
- Conditions
- Multiple Sclerosis, Demyelinating Disease, Inflammatory Disease
- Trial name
- NCT04997343
- Testing
- Neurophysiological assessment, clinical assessment
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Parkinson Disease, Deep Brain Stimulation
Understanding Motivation in Parkinson's Patients Through Neurophysiology
The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device.
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Motivation
- Trial name
- MPPN (NCT05065151)
- Testing
- Stimulation on, Stimulation off, Decision Making Task
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Stroke, Hemiparesis
Mechanism of Action of Focal Extracorporeal Shock Waves as a Treatment of Upper Limb Stroke Spasticity: a Pilot Study
Spasticity, common after a stroke, aggravates the patient's motor impairment causing pain and limitation in daily activities such as eating, dressing and walking.
- Conditions
- Stroke, Hemiparesis, Hemiplegia, Spasticity as Sequela of Stroke
- Trial name
- SASHA (NCT06311526)
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Auxologico Italiano
Postpartum Depression
Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition
Understanding the neural and biological mechanisms by which reproductive hormones influence mood is critically important for public health given that postpartum depression (PPD) is the leading cause of morbidity and mortality…
- Trial name
- NCT01762943
- Testing
- Leuprolide Acetate, Micronized estradiol, Progesterone
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cancer, Cancer Head Neck
Neuroinflammation in Chronic Systemic Symptoms (CSS)
The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).
- Conditions
- Cancer, Cancer Head Neck, Neuroinflammatory Response, Chronic Inflammation
- Trial name
- NCT04636723
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Infant Development
Assessment of Motor Development With a Wearable in Rural and Low-income Settings
The MaMa study aims to assess feasibility and validity of an infant wearable in a rural settings. Altogether N~100 infants will be recruited and measured multiple times at homes from age 6 months to age 18 months.
- Trial name
- MaMa (NCT05782673)
- Testing
- wearable MAIJU for motor assessment
- Where
- 4 sites in Finland, Malawi
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Cognitive Change
Impact of Challenging Engagement on Cognition in Older Adults
The study will enroll 90 participants in the "Impact of Challenging Engagement" study and assign them to one of three groups: high-demand photography, moderate-demand photography, and active placebo.
- Trial name
- engAGE (NCT03962439)
- Testing
- High-Demand Photography, Moderate-Demand Photography, At-Home Engagement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Attention Deficit Hyperactivity Disorder
Neuropsychology, Neuroimage and Neurophysiology in Adults With ADHD
We anticipate that drug-naïve ADHD probands, particularly those with DAT1 or SLC6A2 gene variants may have higher level of altered microstructural integrity of frontostriatal (FS), frontoparietal (FP), other hypothesized fiber…
- Trial name
- NCT02642068
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Oro-Facial-Digital Syndrome
Mindfulness and Education in Patients With Non-oncological Orofacial Pain
To analyze the effects of a program based on Mindfulness plus Pain Neurophysiology Education versus a program based on Pain Neurophysiology Education on perceived quality of life, pain, sleep quality, and functionality, in adult…
- Trial name
- NCT05732753
- Testing
- Mindfulness + Education in Neurophysiology of pain
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Jaén
Physiological Stress
Operational Performance Effects and Neurophysiology in Partial Gravity
Aim 1: Characterize and quantify changes in operationally-relevant sensorimotor and vestibular performance as a function of gravitational load.
- Trial name
- OPEN-PG (NCT06736652)
- Testing
- Parabolic flight
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital