Clinical trials: Neurophysiology, open to volunteers
Menopause Surgical
Hormonal Regulation of Cardiometabolic Health Study
The goal of this observational study is to understand how the loss of ovarian function after oophorectomy affects the health and well being of women aged 35-50. The study focuses on four areas: 1.
- Trial name
- HoCa (NCT07406412)
- Testing
- Surgical removal of ovaries, Hormone Replacement Therapy (HRT)
- Where
- 7 sites in Finland
- Volunteers
- 120 people
- Sponsor
- University of Jyvaskyla
Glioma, Tumor
A First-in-Human Study of the CIPHER System During Brain Surgery for Newly Diagnosed Glioma
The goal of this clinical trial is to collect data on the use of the CIPHER System when used by a surgeon during brain tumor removal.
- Conditions
- Glioma, Tumor, Electrocorticography, Brain
- Trial name
- CIPHER (NCT07465796)
- Testing
- Electrocorticography for neural recording, Electrocorticography for neural recording and electrical stimulation
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Coherence Neuro Australia Pty Limited
Healthy Volunteer
NEURO-IS: Neurophysiology of Inner Speech Across Neurotypical Participants.
The purpose of this study is to investigate the brain activity associated with two common inner experiences: visual mental imagery (mentally seeing objects or actions) and inner speech (experiencing language without speaking out…
- Trial name
- NEURO-IS (NCT07885020)
- Testing
- Inner Experience Induction Tasks and hdEEG
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Liege
Digital Nerve Injury, Sensory Neurography
Sensory Neurography and S2PD After Digital Nerve Injury
The goal of this clinical comparative cross sectional study, is to investigate neurophysiological findings and S2PD (static two point discrimination test) measurements after digital nerve injury.
- Conditions
- Digital Nerve Injury, Sensory Neurography, S2PD
- Trial name
- NCT07904286
- Testing
- Sensory neurography, Static two point discrimination test, S2PD
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Cecilia Mellstrand Navarro
Knee Osteoarthristis, Knee Pain Arthritis
Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee
Knee osteoarthritis is a leading cause of disability, and the muscle weakness that limits walking in this population arises not only from the joint itself but from afferent signals that inhibit motor drive to the thigh muscle…
- Conditions
- Knee Osteoarthristis, Knee Pain Arthritis, Knee Pain Chronic
- Trial name
- SPARK (NCT07832669)
- Testing
- Peripheral Electrical Stimulation (PES), Paired Pulse Electrical Stimulation (ppES)
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Pleural Effusion
Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion
The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.
- Trial name
- COSINE (NCT05945043)
- Testing
- Surface parasternal eletromyogram, Surface diaphragm electromyogram, Parasternal muscle ultrasound
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Spinal Cord Injury
Testosterone and Neural Function in Men With Spinal Cord Injury
Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS).
- Trial name
- NCT06130449
- Testing
- Natesto testosterone intranasal gel, Ayr Saline Nasal Gel
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Movement Disorders
Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor…
- Trial name
- NCT06848530
- Testing
- Prescribed Medications, Deep brain stimulation adjustment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Neurodevelopmental Disorders
Individual Neurophysiological Sensory Profiles in People With and Without Neurodevelopmental Disorders
The goal of this observational study is to evaluate intra-individual neurophysiological variability in children and adults with and without NeuroDevelopmental Disorders (NDD), for several sensory modalities and types of…
- Trial name
- SensAUry (NCT07542977)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Parkinson Disease
Neurophysiology of Reward Signaling in Parkinson's Disease
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors.
- Trial name
- NCT07409207
- Testing
- Neurophysiology recordings, Neural stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Itching
A New Model to Induce Itch and Inflammation
This project aims to create a reliable, long-lasting itch model by synergistically combining thermal pre-conditioning with the application of histamine or cowhage.
- Trial name
- NCT07395882
- Testing
- Cowhage (Mucuna Pruriens), Histamine, Heat
- Where
- Denmark
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Gender Dysphoria, Adult
Comparative Study of Gender Identity Disorder Versus Control
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.
- Trial name
- TRANSIDENT (NCT04935164)
- Testing
- Psychiatric evaluations
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Henri Laborit
Parkinson Disease, Deep Brain Stimulation
Understanding Motivation in Parkinson's Patients Through Neurophysiology
The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device.
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Motivation
- Trial name
- MPPN (NCT05065151)
- Testing
- Stimulation on, Stimulation off, Decision Making Task
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Tourette Syndrome, Tic Disorder
Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder
Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population.
- Trial name
- NCT06576726
- Testing
- This study involves no intervention.
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Fear Avoidance
Knowledge, Attitudes, and Beliefs About Musculoskeletal Pain Among Primary Care Health Professionals in Spain.
Pain is influenced by psychological and emotional factors, and healthcare professionals may unintentionally contribute to chronic disability by reinforcing fear and limiting normal activity.
- Trial name
- CACDAPES (NCT06900231)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Universitat de Lleida
Generalized Anxiety Disorder (GAD), Anxiety Disorders
EEG Study on Neurophysiological and Psychological Effects of Ericksonian Hypnotherapy in Generalized Anxiety Disorder
This study examines the neurophysiological and psychological effects of Ericksonian hypnotherapy in individuals diagnosed with Generalized Anxiety Disorder (GAD).
- Conditions
- Generalized Anxiety Disorder (GAD), Anxiety Disorders, Psychophysiological Disorders, Stress-Related Disorders
- Trial name
- EEG-HypnoGAD (NCT06811311)
- Testing
- Ericksonian Hypnotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uskudar University
Parkinson Disease
Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain…
- Trial name
- NCT04715984
- Testing
- Neurophysiology recordings, Neural stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking.
- Trial name
- NCT06911229
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Treatment Resistant Depression
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- SYNVEST (NCT06512220)
- Testing
- Psilocybin 25 mg, Risperidone 1 MG
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre for Addiction and Mental Health