Clinical trials: Neuroplasticity
Stroke, Hemiplegia
Brain Stimulation and Rehabilitation for Adults With Chronic, Severe Arm Motor Impairment After Stroke
This pilot study will examine a combination therapy for adults with chronic, severe motor impairment of an arm after stroke. The intervention will combine brain stimulation with physical rehabilitation of the arm on the side of…
- Conditions
- Stroke, Hemiplegia, Hemiparesis
- Trial name
- NCT03538795
- Testing
- iTBS&eCIMT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Alabama at Birmingham
Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Mindfulness-based Psilocybin Therapy for PTSD
The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- NCT07104916
- Testing
- Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anthony P King
Dravet Syndrome (DS)
Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome
Dravet syndrome (DS) is a developmental and epileptic encephalopathy, usually caused by de novo pathogenic SCN1A variants, characterized by early-onset prolonged febrile seizures, subsequent drug-resistant polymorphic epilepsy…
- Trial name
- TEMBO-DS (NCT07801404)
- Where
- 9 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Glucose Metabolism Disorders, Obesity
To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity.
To test the hypothesis that GLP1 can exert favourable effects on multiple aspects of brain function. To this purpose, the investigator determine whether chronic increase in GLP1 concentration as it occurs after bariatric surgery…
- Conditions
- Glucose Metabolism Disorders, Obesity, Degenerative Brain Disorder
- Trial name
- NCT03414333
- Testing
- RYGB, GLP-1
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Pisa
Schizophrenia, Schizo Affective Disorder
D-serine Augmentation of Neuroplasticity
Schizophrenia is a major public health problem associated with cognitive deficits, such as short and long term memory, executive functioning, attention and speed of processing that are amongst the strongest predictors of impaired…
- Trial name
- NCT03711500
- Testing
- D-serine
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- New York State Psychiatric Institute
Cerebral Palsy
Activities-based Locomotor Training Program Versus Traditional Physical Therapy in Children With Cerebral Palsy
The purpose of this study is to investigate the impact of an intensive activities-based locomotor training program as compared to traditional physical therapy on activity, participation, and central and peripheral…
- Trial name
- NCT06352814
- Testing
- Activities-based locomotor training (physical therapy)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Baylor University
Brain Function, Cerebral Palsy
7T Anatomo-functional Characterization of Structures in the Action Observation Network
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the…
- Trial name
- 7T-ATHENA (NCT06826287)
- Testing
- 7T MR exam, clinical assessment
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Stroke
Reliability of Paired Associative Stimulation-induced Neuroplasticity After Stroke
Paired associative stimulation (PAS) is a non-invasive stimulation method which is known to modulate corticospinal excitability through mechanisms related to long-term potentiation and long-term depression.
- Trial name
- PASS (NCT03861806)
- Testing
- PAS true
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Burke Medical Research Institute
Stroke
Neurofeedback for Stroke Rehabilitation
Real-time neurofeedback aims to alter brain activation patterns through online feedback of ongoing brain activity using magnetic resonance imagining (MRI).
- Trial name
- NCT03775915
- Testing
- Neurofeedback
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Oxford
Stroke
IMPACT OF COMPUTERIZED GLOVE ON FACILITATING HAND FUNCTION RECOVERY AND NEURAL PLASTICITY IN STROKE
Hand impairment post-stroke is a common condition that contributes to disability around the world. An effective intervention is required to optimize functional outcomes in the rehabilitation of hand-in-stroke patients.
- Trial name
- NCT06520748
- Testing
- Hand rehabilitation program using the computerized glove, Selected hand program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ahmed Alshimy
Healthy
Probing TBS-induced Neural Plasticity and Associated Effects on Learning
Recent animal research indicates that excitatory brain stimulation opens a time window of increased neural plasticity that permits remodeling of neural representations.
- Trial name
- NCT03756584
- Testing
- Theta-burst stimulation
- Where
- Hong Kong
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dr Georg Kranz
Major Depressive Disorder
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
The primary goal of this pilot study is to investigate whether psilocybin alters neuroplasticity in people with major depressive disorder.
- Trial name
- NCT03554174
- Testing
- Low Dose Psilocybin, Medium Dose Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Stroke
Repetitive Bihemispheric Transcranial Direct Current Stimulation After Stroke
Non-invasive repetitive bi-hemispheric transcranial direct current stimulation (tDCS) may restore post-stroke bi-hemispheric balance by increase peri-lesional cortex activity and suppress abnormal inhibition from non-lesional…
- Trial name
- NCT02731508
- Testing
- Bihemispheric transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Glioma (Any Grade) in the Brain, Gliomas, Malignant
Brain Connectivity Changes in Glioma Patients During Treatment
The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as…
- Conditions
- Glioma (Any Grade) in the Brain, Gliomas, Malignant, fMRI Research, Neurocognitive Function
- Trial name
- GliRecon (NCT07612917)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Johannes Kepler University of Linz
Cryptogenic Epilepsy
Diffusion Tensor Imaging in Epilepsy With Continuous Spikes and Waves During Sleep
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic encephalopathy. Even if the correlation between the severity of the epilepsy and the cognitive consequences is well established, the mechanisms…
- Trial name
- POCS-DTI (NCT03035513)
- Testing
- Continuous spikes and waves during slow sleep (CSWS)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for…
- Trial name
- NCT05247125
- Testing
- Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Brain Aging
Synaptic Plasticity Imaging With Diffusion MRI
Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique.
- Trial name
- NCT01686516
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Post-stroke Patient in Acute, Sub-acute Phase or Chronic
The Effects of Muscle Vibration on the Development of Spasticity and Neuroplasticity in a Post-stroke Population
Several studies have recently tested the use of muscle vibration for the rehabilitation of patients after a stroke. When applied in a repeated and focused manner, this vibration appears to promote the recovery of functional…
- Trial name
- SPACE-TIC (NCT05315726)
- Testing
- Dynamometer, Muscle vibrations
- Where
- 2 sites in France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Spinal Cord Injuries
Dosing of Overground Robotic Gait Training With Functional Outcomes and Neuroplasticity After Spinal Cord Injury
The DOOR SCI project examines dosing effects of robotic gait training (RGT) and transcranial magnetic stimulation (TMS) initiated during inpatient rehabilitation and continued through early outpatient rehabilitation
- Trial name
- DOORSCI (NCT05218447)
- Testing
- Robotic Gait Training, Usual Care (UC) Gait Training
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Baylor Research Institute
Cocaine Use Disorder, Healthy Controls
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
- Trial name
- NCT04721418
- Testing
- 11C-UCB-J
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale University