Clinical trials: Neuroprotection
Stroke, Ischemic
Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention
Ischemic stroke is the leading cause of long-term disability in the United States. Endovascular intervention with mechanical thrombectomy has become the standard of care for acute large vessel occlusion (LVO) stroke since…
- Trial name
- NCT05032781
- Testing
- Intra-arterial cold saline, minocycline, and magnesium
- Where
- United States
- Sponsor
- Northwell Health
Parkinson's Disease
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease
This study was designed to evaluate the symptomatic effects of Coenzyme Q10 nanodispersed solution in middle-stage Parkinson's disease (PD) patients (Hoehn\&Yahr II to III).
- Trial name
- NCT00180037
- Testing
- Coenzyme Q10 Nanodispersion (Nanoquinone)
- Where
- 13 sites in Germany
- Volunteers
- 132 people
- Sponsor
- Technische Universität Dresden
Infant, Premature, Leukomalacia, Periventricular
Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants. Inflammation, hypoxia-ischemia, free oxygen radical formation and excitotoxicity are all known pathogenic mechanisms that…
- Conditions
- Infant, Premature, Leukomalacia, Periventricular, Intraventricular Hemorrhage, Retinopathy of Prematurity
- Trial name
- NCT00910234
- Testing
- recombinant human erythropoietin (rhEpo), Normal saline
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Stroke
The Safety of High Dose Minocycline in the Patient Population Undergoing Carotid Revascularization
The purpose of this study is to evaluate the safety and tolerability of high-dose minocycline in the patient population undergoing carotid revascularization procedures, namely carotid endarterectomy (CEA) and carotid artery…
- Trial name
- NCT02178813
- Testing
- Administration of minocycline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Premature Birth, Extreme Prematurity
The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants
To study the safety and efficacy of intranasal administration of exosomes derived from mesenchymal stromal cells on long-term neurodevelopmental outcome in extremely low birth weight infants born at gestational age 25/0-27/6…
- Conditions
- Premature Birth, Extreme Prematurity, Preterm Intraventricular Hemorrhage, Hypoxia-Ischemia, Cerebral
- Trial name
- NCT05490173
- Testing
- Exosomes derived from mesenchymal stromal cells (MSCs)
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Dexmedetomidine
Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
Neuroapoptosis is induced by the administration of anesthetic agents to the young brain. Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role during development and is neuroprotective in…
- Trial name
- NCT03234660
- Testing
- Dexmedetomidine Hydrochloride, control
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Stroke, Ischemic, Stroke, Acute
Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy in Acute Ischemic Stroke.
This study is designed to determine the efficacy and safety of Cerebrolysin treatment as an add- on therapy to mechanical thrombectomy (MT) in reducing global disability in subjects with acute ischemic stroke (AIS).
- Conditions
- Stroke, Ischemic, Stroke, Acute, Stroke Sequelae
- Trial name
- NCT04904341
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Military Institute od Medicine National Research Institute
Stroke, Acute, Ischemic Stroke
Maimonides Minocycline in Stroke Study
The goal of this study is to determine if oral Minocycline's proposed neuroprotective effects further improve the clinical outcomes, including mortality, of acute stroke patients beyond the current standard stroke care in a large…
- Conditions
- Stroke, Acute, Ischemic Stroke, Hemorrhagic Stroke, Mortality
- Trial name
- NCT06107725
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Maimonides Medical Center
Congenital Heart Disease
Dexmedetomidine Neuroprotection in Pediatric Cardiac Surgery
Neurodevelopmental disability is the most significant complication for survivors of infant surgery for congenital heart disease.
- Trial name
- NCT04484922
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Non-arteritic Ischemic Optic Neuropathy
Citicoline in Non-Arteritic Ischemic Optic Neuropathy
The investigators tested the hypothesis whether the treatment with Citicoline in oral solution (OS-Citicoline) would increase or stabilize visual acuity, retinal ganglion cells (RGCs) function and neural conduction along the…
- Trial name
- NCT03758118
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Stroke, Ischemia Stroke
Minocycline in Stroke Study at Maimonides
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.
- Conditions
- Stroke, Ischemia Stroke, Hemorrhagic Strokes, Mortality
- Trial name
- NCT07237048
- Testing
- Minocycline 200mg
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Joyce Chen
Ischemic Stroke
Molecular Mechanisms of microRNA-494 Involving in Cerebral Ischemia
We and other investigations suggested that the activation of nerve cell cycle following cerebral ischemia led to neuronal apoptosis, glial cell proliferation and the formation of glial scar.The cyclin-dependent kinases (CDKs) and…
- Trial name
- NCT03577093
- Testing
- There is no intervention at all.
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Capital Medical University
Carotid Artery Stenosis, Strokes
Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes
The investigators hypothesize that pre-operative statin use is neuroprotective at maximal doses. The goals are to determine the safety, feasibility, and efficacy of maximizing statin doses for two weeks (12-18 days) prior to CEA…
- Trial name
- STANCE (NCT02850081)
- Testing
- Statin, Atorvastatin
- Where
- 7 sites in United States
- Volunteers
- 31 people
- Sponsor
- Columbia University
Multiple System Atrophy
Long-term Follow-up of Phase 1 Clinical Trial of CS10BR05(CS10BR05-MSA101)
The study purpose is conducting follow-up surveillance for the incidence of adverse events and efficacy of subjects participated in phase 1 trial to evaluate the safety and tolerability of autologous bone marrow-derived…
- Trial name
- NCT04495582
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Corestemchemon, Inc.
Cardiac Arrest, Coma
GLP-1 Analogs for Neuroprotection After Cardiac Arrest
Experimental studies and previous clinical trials suggest neuroprotective effects of GLP-1 analogs in various degenerative neurological diseases, and in hypoxic brain injuries in experimental designs.
- Trial name
- GLIP1 (NCT02442791)
- Testing
- Byetta (Lilly, Exenatide), 20% Human Albumin
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Jesper Kjaergaard
Secondary Progressive Multiple Sclerosis
A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis
A present there is no safe treatment for reducing rate at which disability worsens in people with secondary progressive multiple sclerosis.
- Trial name
- NCT00257855
- Testing
- Lamotrigine
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University College London Hospitals
Retinal Detachment
Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment
This randomised, double-blind, placebo-controlled clinical trial investigates the neuroprotective effect of rasagiline in patients suffering from a retinal detachment affecting central vision.
- Trial name
- NCT02068625
- Testing
- Rasagiline
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple System Atrophy, Progressive Supranuclear Palsy
Neuroprotection and Natural History in Parkinson's Plus Syndromes (NNIPPS)
NNIPPS is a clinical trial of riluzole (a drug previously shown to slow down the rate of progression og amyotrophic lateral sclerosis-ALS; Lou Gehrig's disease) involving nearly 800 people diagnosed with the 'parkinson plus'…
- Trial name
- NCT00211224
- Testing
- Riluzole
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- King's College London
Carotid Artery Diseases
Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty
Cerebral embolization during carotid artery stenting (CAS) can often precipitate severe adverse neurological effects. Most major clinical studies of CAS have used distal filters for cerebral protection and have compared the…
- Trial name
- PROOF (NCT01264419)
- Testing
- Silk Road Embolic Protection System
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Silk Road Medical
Acute Ischemic Stroke
Transcranial Direct Current Stimulation as a Neuroprotection in Acute Stroke Before and After Thrombectomy
This proposal is a prospective, single-center, dose-escalation safety, tolerability, feasibility and potential efficacy study of transcranial direct current stimulation (tDCS) in acute stroke patients with substantial salvageable…
- Trial name
- TESSERACT-BA (NCT04061577)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Los Angeles