Clinical trials: Neuroprotective
Stroke, Ischemic
Neuroprotective Effect of Remote Ischemic Conditioning in Ischemic Stroke Treated With Mechanical Thrombectomy
The benefit of mechanical thrombectomy in the treatment of ischemic stroke has been demonstrated in several multicenter randomized trials.
- Trial name
- PROTECT-I (NCT03915782)
- Testing
- Remote ischemic conditioning
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
Glaucoma
Metformin as a Neuroprotective Therapy for Glaucoma
Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve…
- Trial name
- NCT05426044
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Christopher Kai Shun Leung
Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus
Treatment of Diabetic Neuropathy With Liraglutide
The purpose of this trial is to explore whether liraglutide has a long term effect on clinical symptoms and biomarkers in patients with diabetic neuropathy.
- Trial name
- TODINELI (NCT02138045)
- Testing
- Liraglutide treatment
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Aalborg University Hospital
Amyotrophic Lateral Sclerosis
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis
In this proposed study, the investigators will evaluate the safety and efficacy of lipoic acid in treatment of Amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT04518540
- Testing
- lipoic acid group, control group
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Small Cell Lung Carcinoma
Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain
This phase I/II trial studies the effects and safety of giving lithium carbonate (lithium) to patients with small cell lung cancer (SCLC) undergoing radiation therapy to the brain (PCI; prophylactic cranial irradiation).
- Trial name
- NCT01553916
- Testing
- Lithium Carbonate, Prophylactic cranial irradiation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Washington University School of Medicine
Cerebral Ischemia, Cardiac Arrest
Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients
The primary objective of the Neuroprotect trial is to assess whether or not a new goal directed hemodynamic optimization strategy can reduce cerebral ischemia in post-cardiac arrest (CA) patients.
- Trial name
- NEUROPROTECT (NCT02541591)
- Testing
- Neuroprotective goal directed hemodynamic optimization, MAP > 65mmHg
- Where
- 2 sites in Belgium
- Volunteers
- 112 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke, Ischemic, Intravascular Thrombosis
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.
- Conditions
- Stroke, Ischemic, Intravascular Thrombosis, Mechanical Thrombectomy
- Trial name
- NCT04664933
- Testing
- Intra-arterial administration of neuroprotective agents
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Acute Ischemic Stroke (AIS)
Study of the Safety and Neuroprotective Capacity of Scp776 in Acute Ischemic Stroke
A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study of the Safety and Neuroprotective Capacity of Scp776 in Subjects Undergoing Endovascular Thrombectomy for Acute Ischemic Stroke
- Trial name
- ARPEGGIO (NCT05585606)
- Testing
- scp776 (1.9 mg/kg), scp776 (3.8 mg/kg), scp776 (4.8 mg/kg)
- Where
- 22 sites in United States
- Volunteers
- 120 people
- Sponsor
- Silver Creek Pharmaceuticals
Neurological Diseases, Ischemic Stroke
Establishment of Clinical Basis for Hematopoietic Growth Factors Therapy in Brain Injury
The purpose of our study is to determine the safety and efficacy of the combination of erythropoietin (EPO) and granulocyte-colony stimulating factors (G-CSF) in patients with neurological diseases.
- Conditions
- Neurological Diseases, Ischemic Stroke, Hemorrhagic Stroke, Cerebral Palsy
- Trial name
- NCT02018406
- Testing
- Combination injection of EPO and G-CSF, Injection of normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Lactate Therapy After Traumatic Brain Injury
Background: Although glucose is essential to cerebral function, abundant experimental and clinical evidence demonstrates that endogenously released lactate, rather than glucose, is the preferential energy substrate for the brain…
- Trial name
- LS_TCC (NCT01573507)
- Testing
- sodium lactate infusion
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiac Surgery, Brain Injury
The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS)
Context: Neurocognitive dysfunction complicates coronary artery bypass graft surgery. Neurocognitive dysfunction is a measurable problem with thinking. Erythropoietin may be a neuroprotectant.
- Trial name
- NCT00336466
- Testing
- Human recombinant erythropoietin
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Out-of-hospital Cardiac Arrest (OHCA)
Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI).
- Trial name
- KETOHCA (NCT06744361)
- Testing
- esketamine hydrochloride, propofol
- Where
- 2 sites in Denmark
- Volunteers
- 282 people
- Sponsor
- Christian Hassager
Parkinson Disease
Bee Venom for the Treatment of Parkinson Disease
The purpose of this study is to evaluate the efficacy of repeated (monthly) injections of bee venom on motor symptoms of Parkinson's disease over a period of one year, also the potential effects of this treatment on disease…
- Trial name
- MIREILLE (NCT01341431)
- Testing
- bee venom
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
TBI (Traumatic Brain Injury)
Evaluation of the Effect of Neuroprotective Drug on Treatment Result in Patients After Traumatic Brain Injury
Traumatic Brain Injury TBI is one of the most common causes of death and recovery failure worldwide. Each element of treatment, starting from possible surgical treatment, patient monitoring and neuroprotective treatment, can be…
- Trial name
- NCT05807503
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- Pomeranian Medical University Szczecin
Stroke
Iron Chelation in the Prevention of Secondary Degeneration After Stroke
Stroke is a major cause of disability over the world. While acute therapies have made huge progresses, the number of survivors leaving with clinical consequences of stroke is increasing.
- Trial name
- CHEL-IC (NCT05111821)
- Testing
- Magnetic Resonance Imaging (MRI), Deferiprone treatment
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Bordeaux
Optic Neuritis
Atacicept in Subjects With Optic Neuritis
This study was intended to evaluate the efficacy, safety and tolerability of atacicept compared to placebo and to explore the neuroprotective effect of atacicept as assessed by OCT in subjects with ON as CIS.
- Trial name
- NCT00624468
- Testing
- Atacicept
- Where
- 28 sites in United States, Australia and 9 more
- Volunteers
- 34 people
- Sponsor
- EMD Serono
Colorectal Cancer
Neuroprotective Effect of Neurotropin on Chronic OXA-induced Neurotoxicity in Stage II and Stage III CRC Patients
Oxaliplatin is effective in adjuvant and first-line colorectal cancer chemotherapy. Oxaliplatin-induced severe chronic neurotoxicity is the main dose-limiting adverse event.
- Trial name
- NCT07320950
- Testing
- Neurotropin
- Where
- China
- Volunteers
- 333 people
- Sponsor
- Sun Yat-sen University
Diabetic Retinopathy
Trial to Assess the Efficacy of Neuroprotective Drugs Administered Topically to Prevent or Arrest Diabetic Retinopathy
To assess whether neuroprotective drugs administered topically (somatostatin and brimonidine) are able to prevent or arrest the development and progression of neurodegenerative changes
- Trial name
- EUROCONDOR (NCT01726075)
- Testing
- COLIRIOBCN070660, Brimonidine
- Where
- 11 sites in Denmark, France and 5 more
- Volunteers
- 450 people
- Sponsor
- BCN Peptides
Depression
Riluzole to Treat Major Depression
This study will examine the safety and effectiveness of the drug riluzole (Rilutek® (Registered Trademark)) for short-term treatment of depression symptoms, such as depressed mood, psychomotor retardation, and excessive sleeping.
- Trial name
- NCT00026052
- Testing
- riluzole
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute of Mental Health (NIMH)
Traumatic Brain Injury
Comparison Between Effect of Vitamin D Versus Dexmedetomidine in Patients with Head Trauma Using Interleukin 6
in this study the investigators compare between the neuroprotective effect of vitamin d versus dexmedetomidine in patients with traumatic brain injury using interleukin 6 as inflammatory biomarker
- Trial name
- NCT06565338
- Testing
- Dexmedetomidine, Vitamin D3
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University