Clinical trials: Neuroprotective
Aneurysm, Ruptured, Coiling Therapy
The Neuroprotective Effect of Remote Ischemic Conditioning in Ruptured Aneurysm Coiling Therapy
The overall incidence of DWI positive for thromboembolic events following endovascular treatment of intracranial aneurysms is proximately 50%.
- Trial name
- NEAT-2 (NCT03561311)
- Testing
- remote ischemic conditioning
- Where
- 5 sites in China
- Volunteers
- 210 people
- Sponsor
- Capital Medical University
Psychosis, Healthy
Is Cognitive Training Neuroprotective in Early Psychosis?
The purpose of this study is to perform longitudinal high-resolution 7T MRI and Prisma 3T MRI in participants with first-episode psychosis (FEP) enrolled in our ongoing randomized controlled clinical trial (RCT) of cognitive…
- Trial name
- NCT03049800
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson's Disease
Parkinson's Disease Isradipine Safety Study
The objective of this study is to establish the safety and tolerability of isradipine, sustained release preparation in patients with PD.
- Trial name
- NCT00753636
- Testing
- Dynacirc CR (Isradipine)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwestern University
Traumatic Brain Injury
Efficacy of Ketamine in Children With Severe Brain Injury for Brain Cell Protection
The purpose of this study is to determine the possible effects of an anesthetic agent called Ketamine on the injured brain in children. The researchers think that it will effect the outcomes of children with these injuries.
- Trial name
- NCT00556387
- Testing
- saline, Ketamine
- Sponsor
- University of Arkansas
Neurodegenerative Diseases
Citicoline Concentration in Human Vitreous
Elegible patients were included in the study and underwent treatment with a solution of citicoline 1% eye-drops, 0.2% high molecular weight hyaluronic acid and 0.01% benzalkonium chloride prior to surgery.
- Trial name
- NCT04003090
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Istituto di Ricerca Neuroftalmologia S.r.l.
Butylphthalide, Cardiac Arrest
Butylphthalide's Safety and Efficacy for Improving Neurological Function Prognosis in Patients With Cardiac Arrest (BNCA Trial)
Butylphthalide (NBP) is a neuroprotective medication capable of ameliorating neurological dysfunction induced by ischemia, hypoxia, and reperfusion injury in the brain.
- Conditions
- Butylphthalide, Cardiac Arrest, Neuroprotective Drugs
- Trial name
- NCT06353334
- Testing
- Butylphthalide and Sodium Chloride Injection, Saline Solution
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang Ziren
Posttraumatic Stress Disorder
Neuroprotective/Neurotrophic Effect of Lexapro® in Patients With Posttraumatic Stress Disorder
The objectives of the current study are 1. to evaluate the efficacy of escitalopram in treatment for post-traumatic stress disorder, 2.
- Trial name
- NCT01008098
- Testing
- escitalopram (lexapro)
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Seoul National University Hospital
Ketamine-Induced Neurotoxicity
Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10
The compound ACTH4-10Pro8-Gly9-Pro10 is a synthetic analog molecule of an adrenocorticotropic hormone (ACTH) short fragment. That is free from hormonal effects and has neuromodulatory effects.
- Trial name
- NCT05648526
- Testing
- ACTH4-10Pro8-Gly9-Pro10, Ketamine
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Sumatera Utara
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Cardiac Arrest With Successful Resuscitation, Post Cardiac Arrest Syndrome
- Trial name
- STEROHCA (NCT04624776)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 2 sites in Denmark
- Volunteers
- 158 people
- Sponsor
- Christian Hassager
Retinal Detachment
Evaluation of Neuroprotective Effect of Minocycline
This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .
- Trial name
- minocyclin &RD (NCT01297816)
- Testing
- Minocycline
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Relapsing-Remitting Multiple Sclerosis
The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis
This study is designed to evaluate the neuroprotective effect of lamotrigine in the combination of interferon beta 1a once weekly intramuscular in patients with relapsing-remitting multiple sclerosis.
- Trial name
- NCT00917839
- Testing
- lamotrigine
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- Cantonal Hospital of St. Gallen
Stroke, Dehydration
Neuroprotective Therapy and Therapeutic Target in Emergency Department
The investigators studied laboratory measurements and previously identified risk factors to identify factors predictors of early deterioration following stroke.
- Trial name
- NCT02143596
- Testing
- normal saline
- Where
- Taiwan
- Volunteers
- 159 people
- Sponsor
- Chang Gung Memorial Hospital
Neuroprotection, Parkinson Disease
Neuroprotective Effects of iTBS in PD
Intermittent theta burst stimulation (iTBS) is an emerging non-invasive neuron regulation technique, which is widely used in neuropsychiatry for a variety of diseases and is widely accepted by patients due to its non-invasive…
- Conditions
- Neuroprotection, Parkinson Disease, Intermittent Theta Burst Stimulation
- Trial name
- NCT05445505
- Testing
- intermittent theta burst stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Aneurysm, Ruptured, Vasospasm, Intracranial
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
Previous work has demonstrated patients presenting with ruptured aneurysms that develop radiographic and clinical vasospasm have a higher permeability of the blood brain membrane.
- Conditions
- Aneurysm, Ruptured, Vasospasm, Intracranial, Delayed Cerebral Ischemia, Blood Brain Barrier Defect
- Trial name
- NCT04876638
- Testing
- Minocyclin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Acute Ischemic Stroke
Efficacy and Safety of QD202 in Participants With Acute Ischemic Stroke Undergoing Thrombolysis Excluding Endovascular Thrombectomy
This is a randomized, double-blinded, placebo-controlled study investigating the safety and efficacy of QD202 injection in patients with acute ischemic stroke undergoing thrombolysis excluding endovascular thrombectomy.
- Trial name
- NCT07581210
- Testing
- QD202
- Where
- 14 sites in China
- Volunteers
- 120 people
- Sponsor
- Shanghai QuietD Biotechnology Co., Ltd.
Multiple Sclerosis
Safety of Polyphenon E in Multiple Sclerosis Pilot Study
This study is an open label 6 month study. All subjects will be treated with Polyphenon E (400 mg EGCG twice a day) for six months. The main outcome of this pilot phase will be safety.
- Trial name
- NCT00836719
- Testing
- Polyphenon E
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Acute Ischemic Stroke
The Screening of Neuroprotective Biomarkers After Acute Ischemic Stroke
Neuroprotection is expected to be an important therapeutic strategy for acute ischemic stroke(AIS), but almost all neuroprotective drugs proved effective in rodent models have failed after entering clinical trials.
- Trial name
- NCT05689528
- Where
- China
- Volunteers
- 453 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
DEMMMI, Nine-Hole-PEG-Test, mRS, Stroke, Acute
Ghrelintrial With Patients With Stroke
Patients are assigned to KSW's Stroke Unit as part of the emergency treatment. There the patients are included in the study and treated according to the concept on the Stroke Unit within the complex treatment.
- Trial name
- NCT03264742
- Testing
- Ghrelin
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Kantonsspital Winterthur KSW
Multiple Sclerosis
Lipoic Acid for Progressive Multiple Sclerosis (MS)
The purpose of the study is to determine if lipoic acid can preserve mobility and protect the brain in progressive forms of multiple sclerosis.
- Trial name
- LAPMS (NCT03161028)
- Testing
- Lipoic acid
- Where
- 11 sites in United States, Canada
- Volunteers
- 115 people
- Sponsor
- VA Office of Research and Development
Heart Arrest
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R
Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis primarily the cytochrome С Inhibition…
- Trial name
- NCT04287842
- Testing
- Desflurane, Sevoflurane, Cardiac arrest
- Sponsor
- Negovsky Reanimatology Research Institute