Clinical trials: Neuroprotective
22q11.2 Deletion Syndrome
Neuroprotective Effects of Risperdal on Brain and Cognition in 22q11 Deletion Syndrome
Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated with a high risk of psychiatric disorders, including schizophrenia spectrum disorders.
- Trial name
- NCT04639960
- Testing
- Risperdal
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Geneva, Switzerland
Multiple Sclerosis Relapse
The Possible Neuroprotective Effect of Ocrelizumab Via VEGF Protein Expression in Relapsing Multiple Sclerosis Patients
Ocrelizumab (OCR) is a humanized anti-CD20 antibody approved for Relapsing Multiple Sclerosis (RMS) and Primary Progressive Multiple Sclerosis (PPMS), due to neuroprotective effects of partially unknown origin.
- Trial name
- NCT04902690
- Volunteers
- 21 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Amyotrophic Lateral Sclerosis
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)
GM604 is an endogenous human embryonic stage neural regulatory and signaling peptide that controls the development, monitoring and correction of the human nervous system.
- Trial name
- GALS (NCT01854294)
- Testing
- GM604
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Genervon Biopharmaceuticals, LLC
Cerebrovascular Stroke
Feasibility and Safety Study to Evaluate the Neuroprotective Effect of Hemodialysis in Acute Ischemic Stroke
Hemodialysis is a therapeutic strategy used in subjects with chronic renal failure. Our working hypothesis is based on results published in experimental animal models of stroke where the investigators have demonstrated that…
- Trial name
- DIAGLUICTUS2 (NCT04297345)
- Testing
- Hemodialysis
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Vincristine Induced Peripheral Neuropathy (VIPN)
Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy
This study will be conducted to evaluate the effect of vitamin B12 and vitamin B6 in delaying the onset and reducing the incidence and severity of Vincristine Induced Peripheral Neuropathy (VIPN) in Acute Lymphoblastic Leukemia…
- Trial name
- NCT02923388
- Testing
- Injection Mecobalamin,, Tablet Pyridoxine hydrochloride, Intravenous normal saline 1 ml
- Where
- 2 sites in Bangladesh
- Volunteers
- 88 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Parkinson's Disease
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
In phenotypic animal models of Parkinson's Disease (PD), chronic physical exercise has produced nigrostriatal neuroprotection and symptom improvement, provided training was of high-intensity and prolonged duration (>3 months in…
- Trial name
- AEROPROTECT (NCT04046276)
- Testing
- High Intensity Aerobic program, Conventional Physical Therapy, Medium Intensity Aerobic program
- Where
- 3 sites in France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gulf War Illness
Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER)
Since their return from military service in the 1990-1991 Gulf War, many Veterans have been affected by debilitating symptoms that are not easily explained.
- Trial name
- MINER (NCT03665740)
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- VISN 17 Center of Excellence
Diabetes Mellitus, Type 2, Diabetic Nephropathies
Nutritional Outcomes of Lotus Seed (Nelumbo Nucifera) on Diabetic Sensorimotor Polyneuropathy
The study focuses on Diabetic Sensorimotor Polyneuropathy (DSPN), a common complication of type 1 and type 2 diabetes caused by hyperglycemia-induced nerve damage, leading to pain, numbness, and motor dysfunction in the limbs.
- Trial name
- NCT06778018
- Testing
- Lotus Seed
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Coronary Artery Disease, Brain Injury
Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery
In high-income countries, coronary artery bypass grafting (CABG) remains a common procedure, with approximately 36.7 operations per 100,000 inhabitants annually, corresponding to about 136,000 procedures in the European Union.
- Trial name
- HYPNOCABG (NCT07316868)
- Testing
- Normothermic cardiopulmonary bypass, Hypothermic cardiopulmonary bypass
- Where
- Finland
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Glaucoma, Angle-closure, Primary, Acute
Investigating the Neuroprotective Effect of Cop-1 (Copaxone) in Acute Primary Angle Closure
This is a randomised controlled trial to assess the neuroprotective effect of Cop-1 (Copaxone) in patients with acute primary angle closure (APAC).
- Trial name
- NCT01936129
- Testing
- Copaxone
- Where
- Singapore
- Volunteers
- 196 people
- Sponsor
- Singapore Eye Research Institute
Acute Ischemic Stroke
Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP)
Acute ischemic stroke may result in substantial disability despite timely reperfusion therapy because ischemic and reperfusion-related brain injury can continue before, during, and after restoration of blood flow.
- Trial name
- STOP (NCT07840794)
- Testing
- Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lower Extremity Amputee, Diabetic Peripheral Neuropathy
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with above and below the knee limb loss.
- Trial name
- NCT04658693
- Testing
- Implanted Multi contact stimulating electrode and intramuscular electromyography recording electrode
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Out-Of-Hospital Cardiac Arrest
Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest
Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain…
- Trial name
- RIPOST-CA (NCT06473207)
- Testing
- Remote ischemic post conditioning sessions
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Endovascular Thrombectomy, Ischemic Cerebrovascular Accident
A Trial to Assess the Efficacy and Safety of OTR4132-MD in Patients With Acute Ischemic Stroke
The MaTRISS 2 study is a phase 2 randomized, double-blinded and placebo-controlled trial aimed at recruiting 60 subjects (30 placebo and 30 active) from 15 stroke centers in France.
- Trial name
- MATRISS-II (NCT06700824)
- Testing
- OTR4132
- Where
- 15 sites in France
- Volunteers
- 60 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
Postoperative Cognitive Disorder, Glaucoma
Application of Innovative Non-Invasive Neuroprotective Technology in Cardiac Surgery and Ophthalmology
Postoperative cognitive dysfunction (POCD) and delirium (incidence up to 42 %) after cardiac surgery with cardiopulmonary bypass (CPB) are common postoperative complications that impair the patient's quality of life and increase…
- Trial name
- NCT04943458
- Testing
- Monitoring of cerebral autoregulation
- Where
- Lithuania
- Volunteers
- 270 people
- Sponsor
- Milda Svagzdiene
Preterm Birth, Low; Birthweight, Extremely (999 Grams or Less)
Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - MHSB
This study evaluates the use of a NICU clinical integration system (Dashboard and accessories) in improving the quality of care delivered, patient health outcomes, and parent and clinician satisfaction.
- Conditions
- Preterm Birth, Low; Birthweight, Extremely (999 Grams or Less), Neonatal Infection, Satisfaction
- Trial name
- NCT03673579
- Testing
- NICU Dashboard
- Where
- United States
- Sponsor
- Philips Healthcare
Comatose Survivors of Cardiac Arrest
High Dose of Erythropoietin Analogue After Cardiac Arrest
The investigators hypothesised that the neuroprotective effects of erythropoietin and its analogues could lead to an improve outcome after cardiac arrest.
- Trial name
- Epo-ACR-02 (NCT00999583)
- Testing
- EPOETINE ALPHA, Control arm
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke
Improving Neuroprotective Strategy for Ischemic Stroke With Poor Recanalization After Thrombectomy by Intra-arterial TNK (INSIST-TNK)
In 2015, five randomized trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischemic stroke caused by occlusion of arteries of the proximal anterior circulation.
- Trial name
- NCT04201964
- Testing
- Intra-arterial administration of tenecteplase
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Acute Ischemic Stroke, Large Vessel Occlusion
Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment
The goal of this clinical trial is to learn if semaglutide works to treat acute ischemic stroke (AIS). It will also learn about the safety of semaglutide in AIS.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Neuroprotective Drugs, Endovascular Treatment
- Trial name
- GALLOP2 (NCT06788626)
- Testing
- Semaglutide 0.5 mg, Standard medical treatment
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Wei Hu
Cerebrovascular Disorders
Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols
The purpose of the study is to assess the neuroprotective, anti atherogenic and hepatoprotective properties of tocotrienols (palm vitamin E) supplementation as determined by white matter lesion load on serial magnetic resonance…
- Trial name
- NCT00753532
- Where
- Malaysia
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia