Clinical trials: Neuropsychiatric Symptoms
Mild Cognitive Impairment, Alzheimer Disease
Music Therapy for Patients With Alzheimer's Disease
This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or…
- Trial name
- NCT05151562
- Testing
- Virtual Music Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Dementia, Neurocognitive Disorders
Effectiveness and Cost-Effectiveness of Robot Therapy With the Paro Robot in People Living With Dementia
The purpose of this study is to evaluate the effectiveness and cost-effectiveness of group robot therapy with the PARO therapy robot in terms of quality of life and neuropsychiatric symptoms in people living with dementia in…
- Conditions
- Dementia, Neurocognitive Disorders, Mild Cognitive Impairment
- Trial name
- NCT05884424
- Testing
- PARO Therapy Robot
- Where
- 15 sites in Spain
- Volunteers
- 123 people
- Sponsor
- Instituto de Mayores y Servicios Sociales (IMSERSO)
Medication Refractory Epilepsy Patients With Electrodes Already Implanted Based on Clinical Criteria for Standard Monitoring
Model-based Electrical Brain Stimulation
Neuropsychiatric disorders are a leading cause of disability worldwide with depressive disorders being one of the most disabling among them.
- Trial name
- NCT05327387
- Testing
- model-based electrical brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Dementia, Mild Cognitive Impairment (MCI)
Augmented Reality-Based Aromatherapy Education for Older Adults With Early-Stage Dementia in Taiwan
This study evaluates an augmented reality (AR)-based aromatherapy education program designed for older adults with early-stage dementia in Taiwan.
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Neuropsychiatric Symptoms
- Trial name
- NCT07431164
- Testing
- Augmented Reality-Based Aromatherapy Education Program
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan Normal University
Acute Inflammatory Demyelinating Polyradiculoneuropathy, Stroke
Processing Integration in Neurological Patients Using fMRI
The main objective of the study is to explore and map brain areas involved in processing and perception in patients suffering from neurological pathologies and condition.
- Conditions
- Acute Inflammatory Demyelinating Polyradiculoneuropathy, Stroke, Anosognosia, Central and Peripheral Neurodegenerative Pathologies
- Trial name
- NCT02722070
- Testing
- 3 Tesla Siemens Skyra MRI scanner
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Epilepsy, Intellectual Disability
Neuropsychiatric Research Databases for People With Intellectual Disabilities and Epilepsy (REFINE)
This study consists of two parts: Part One: De-identified Database The goal of this part is to establish a research database containing de-identified data about People with Intellectual Disabilities (PwID) and epilepsy, collected…
- Conditions
- Epilepsy, Intellectual Disability, Learning Disability
- Trial name
- REFINE (NCT06780501)
- Where
- 3 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Plymouth
Dementia
Reducing Agitation in People With Dementia: the Customized Activity Trial
Over 5 million Americans have Alzheimer's disease or a related dementia, a progressive and irreversible neurodegenerative condition, affecting also close to 15 million family caregivers (CG).
- Trial name
- TAP (NCT01892579)
- Testing
- Tailored Activity Program, Home Safety and Education Program
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Traumatic Brain Injury, Memory Deficits
Multicenter Evaluation of Memory Remediation After TBI With Donepezil
This is a four-site, randomized, parallel design, double-blind, placebo-controlled, 10-week trial of donepezil 10 mg daily for verbal memory problems among adults with TBI in the subacute or chronic recovery period.
- Trial name
- MEMRI-TBI-D (NCT02255799)
- Testing
- Donepezil
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Baylor College of Medicine
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Apathy, Mild Cognitive Impairment
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
Apathy, a profound loss of initiative and motivation, is often seen in older Veterans with memory problems. Apathy leads to serious health problems, increases dependency, and caregiver burden.
- Conditions
- Apathy, Mild Cognitive Impairment, Transcranial Magnetic Stimulation, Loneliness
- Trial name
- TAMCI (NCT03590327)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease, Deep Brain Stimulation
Can Subthalamic Stimulation Using Directional Electrodes Improve Postoperative Management in Parkinson's Disease
The primary objective of the study is to determine if subthalamic nucleus (STN) deep brain stimulation (DBS) using the Vercise directional leads improves neuropsychiatric state and neuropsychiatric fluctuations 12 months after…
- Trial name
- Steeropt (NCT04578678)
- Testing
- Steering
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 105 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sleep Disturbance, Insomnia
Brief Telehealth CBT-I Intervention in the Context of the COVID-19 Pandemic
The purpose of this study is to investigate whether an empirically validated treatment for insomnia (CBT-I) administered early in the course of sleep disturbance can prevent insomnia disorder or lessen negative mental health…
- Trial name
- NCT04409743
- Testing
- Remote Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Stanford University
Alzheimer Disease, Neurodegenerative Diseases
Mindfulness for Alzheimer Caregivers
Mindfulness Based Health Care (MBHC) includes meditation techniques to help caregivers of Alzheimer patients to be made more aware of their experience in the present moment.
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Dementia
- Trial name
- NCT03858283
- Testing
- Mindfulness Based Health Care (MBHC) Program
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Subjective Cognitive Complaint, Mild Cognitive Impairment
Validation of the MBI-C Scale in French
This study aims to validate the French version of the Mild Behavioral Impairment-Checklist (MBI-C) scale, hypothetically effective for measuring behavioral symptoms in patients presenting with a subjective cognitive complaint or…
- Conditions
- Subjective Cognitive Complaint, Mild Cognitive Impairment, Neuropsychiatric Symptoms
- Trial name
- MBI-C (NCT06516159)
- Testing
- MBI-C Scale in French
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Depression, Anxiety
taVNS on the Inpatient Psychiatric Unit
This is a research study to find out if mental health symptoms in patients admitted to the Institute of Psychiatry are affected by a form of ear stimulation called transcutaneous auricular vagus nerve stimulation, or taVNS.
- Trial name
- NCT05791383
- Testing
- transcutaneous auricular neurostimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Dementia, Depression
Pilot Study to Examine Health Effects of Daylight Exposure on Dementia Patients
This study is designed to test the hypothesis that an intervention increasing exposure to daylight indoors will reduce depression and other neuropsychiatric symptoms among people living with dementia in long term care facilities.
- Conditions
- Dementia, Depression, Behavior Disorders
- Trial name
- NCT03483896
- Testing
- Daylight Intervention
- Where
- 8 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Phenylketonuria
Safety and Therapeutic Effects of Sapropterin Dihydrochloride on Neuropsychiatric Symptoms in Phenylketonuria (PKU) Patients
This double-blind, placebo-controlled, randomized study is designed to evaluate the safety and therapeutic effects of sapropterin dihydrochloride on neuropsychiatric symptoms in subjects with PKU.
- Trial name
- NCT01114737
- Testing
- Sapropterin dihydrochloride
- Where
- 36 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- BioMarin Pharmaceutical
Neuropsychiatric Symptoms Related to Neurodegenerative Disease
A Safety Study of Pimavanserin in Adult and Elderly Subjects Experiencing Neuropsychiatric Symptoms Related to Neurodegenerative Disease
The purpose of this study is to assess the safety and tolerability of pimavanserin compared to placebo in adult and elderly subjects with neuropsychiatric symptoms related to neurodegenerative disease.
- Trial name
- NCT03575052
- Testing
- Pimavanserin
- Where
- 104 sites in United States, Bulgaria and 10 more
- Volunteers
- 784 people
- Sponsor
- ACADIA Pharmaceuticals Inc.