Clinical trials: Neurorehabilitation
Multiple Sclerosis
VR and Orthoses for Rehabilitation in Multiple Sclerosis
This non-drug, non-medical device, interventional study explores the feasibility of integrating virtual reality (VR) with wearable sensors to support gait training using a passive orthosis in individuals with multiple sclerosis…
- Trial name
- VIRTUE (NCT07096700)
- Testing
- VR and walking brace-based gait rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 12 people
- Sponsor
- Azienda Usl di Bologna
Stroke
Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability.
- Trial name
- NCT03390192
- Testing
- Dual-mode stimulation
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy (CP)
Pediatric Endurance and Limb Strengthening Program With and Without Electrical Muscle Stimulation Among Children With Cerebral Palsy
This randomized clinical research will assess the impact of a Pediatric Endurance and Limb Strengthening (PEDAL) program, both with and without Electrical Muscle Stimulation (EMS), on balance, gait, and mobility in children…
- Trial name
- NCT07173647
- Testing
- PEDAL Program with Electrical Muscle Stimulation, PEDAL Program without Electrical Muscle Stimulation
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- University of Lahore
Multiple Sclerosis
Neuromodulation in MS Using Translingual Stimulation
The overarching aim of this study is to examine if there is additional benefit to adding trans-lingual electrical stimulation to physiotherapy aimed at improving walking and balance in people with multiple sclerosis (MS).
- Trial name
- NeuroMSTraLS (NCT05275049)
- Testing
- PT plus translingual stimulation device, PT plus translingual stimulation control device
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University of Saskatchewan
Parkinson Disease, Freezing of Gait
Neurorehabilitation of Sequence Effect in Parkinson's Disease
The sequence effect (SE), defined as a reduction in amplitude of repetitive movements, is a common clinical feature of Parkinson's disease (PD), being a major contributor to freezing of gait (FOG).
- Trial name
- NCT04921748
- Testing
- Neurorehabilitation
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Brain Injuries
The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms
The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the…
- Trial name
- NCT06607523
- Testing
- Inulin
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Stroke
Effect of Task-oriented Training Assisted by Force Feedback Hand Rehabilitation Robot on Finger Function in Stroke Patients With Hemiplegia
Over eighty percent of stroke patients experience finger-grasping dysfunction problems, compromising independence in daily life activities and quality of life.
- Trial name
- NCT05841108
- Testing
- force feedback rehabilitation robot (SEM™ Glove), assisted by a therapist
- Where
- China
- Volunteers
- 44 people
- Sponsor
- The First Hospital of Jilin University
Disorders of Consciousness Due to Severe Brain Injury
Peripheral Nerve Stimulation for Prognostic and Diagnostic Biomarker Identification in Disorders of Consciousness
This observational study aims to integrate anamnestic, clinical, and innovative neurophysiological data to assess their impact on the diagnosis and prognosis of patients with Disorders of Consciousness.
- Trial name
- MICRO-DOC (NCT06845800)
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury (TBI)
Efficacy and Neural Basis of Music-based Neurological Rehabilitation for Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the leading causes of serious, life-long disability among adolescents and young adults. Especially the cognitive, emotional, and motors deficits caused by TBI often impair everyday…
- Trial name
- MUBI (NCT01956136)
- Testing
- Music-based Neurological Rehabilitation (MBNR), Standard Care (SC)
- Where
- 3 sites in Finland
- Volunteers
- 40 people
- Sponsor
- University of Helsinki
Stroke, Aphasia
Transcranial Alternating Current Stimulation in Post Stroke Aphasia Therapy
This study aims to investigate the efficacy of transcranial alternating current stimulation (tACS) combined with linguistic training for patients with chronic post-stroke aphasia.
- Trial name
- AfatES (NCT07510464)
- Testing
- active 75 Hz transcranial alternating current stimulation
- Where
- Poland
- Volunteers
- 11 people
- Sponsor
- QVITI S.A.
Dementia, Mobile Applications
Pilot Study Person-centred Tablet Intervention
First evaluation of FindMyApps, a tablet intervention consisting of a selection tool for usable apps for self-management and meaningful activities and a training that supports informal carers to help people with dementia to learn…
- Conditions
- Dementia, Mobile Applications, Computers, Neurological Rehabilitation
- Trial name
- NCT04026061
- Testing
- FMA group, Control group
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Saxion University of Applied Sciences
Stroke
Effects of Using Advanced NEUROrehabilitation TECHnologies in Upper Limb Motor Function and Capacity Recovery in People With Stroke
This study aims to evaluate the effect of a personalized technology-based rehabilitative intervention on Upper Limb (UL) motor function and capacity recovery in People with Stroke (PwS).
- Trial name
- NEURO-TECH (NCT07698405)
- Testing
- Technology-based UL rehabilitation
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Stroke, Incomplete Spinal Cord Injury
ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)
The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to…
- Conditions
- Stroke, Incomplete Spinal Cord Injury, Gait Impairment Following Orthopedic Surgery
- Trial name
- NCT07735702
- Testing
- Robotic lower-limb gait training (ZEPU-AI5), Standard-of-care rehabilitation (conventional physiotherapy)
- Where
- Bangladesh
- Volunteers
- 51 people
- Sponsor
- Bangladesh Medical University
Ischemic Stroke, Upper Extremity Hemiparesis
Stroke Wearable Operative Rehabilitation Device Impact Trial
The objective of this study is to determine the impact of vibratory feedback on the quality and intensity of a common motor rehabilitation task of the upper-arm (hand-to-mouth) in stroke patients.
- Trial name
- SWORD-IT (NCT01967290)
- Testing
- Vibratory feedback and 3D movement analysis, Only 3D movement analysis
- Where
- 3 sites in Portugal
- Volunteers
- 44 people
- Sponsor
- Centro Hospitalar de Entre o Douro e Vouga
Hemiparesis;Poststroke/CVA
Stroke Patients', Music Therapist' Engagement and Patients' Finger Movement During Music Therapeutic Interaction
Background: Hand functional impairments are common among stroke patients. Rehabilitation therapies increase the possibility of functional recovery.
- Trial name
- NCT05399121
- Testing
- Piano Learning then Free Improvisation, Free Improvisation then Piano Learning
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Reuth Rehabilitation Hospital
Parkinson Disease, Occupational Therapy Students
Effect of AI Chatbot-Assisted Versus Traditional Case-Based Learning on Clinical Reasoning in Occupational Therapy Students: A Study on Parkinson's Disease
This study aims to examine whether using an artificial intelligence (AI) chatbot can enhance occupational therapy students' learning during a case-based activity focused on Parkinson's disease.
- Conditions
- Parkinson Disease, Occupational Therapy Students, Clinical Reasoning, Neurologic Rehabilitation
- Trial name
- AI-PD-OT25 (NCT07045077)
- Testing
- AI Chatbot-Assisted Case-Based Learning, Traditional Case-Based Learning with Standard Materials
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ceyhun Türkmen
Mild Cognitive Impairment
Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Mild Cognitive Impairment
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of mild cognitive impairment (MCI) patients' cognitive function by altering the cortical…
- Trial name
- NCT03647345
- Testing
- High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC, High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
Cognitive Impairment, High Fall Risk
Fall Prevention in Mild Cognitive Impairment
Falls represent the leading cause of hospitalization, nursing home admissions, disability and mortality for older adults with annual healthcare costs over $50 billion.
- Trial name
- NEUROFALL (NCT07507812)
- Testing
- Virtual Neurophysiological Rehabilitation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana