Clinical trials: Neuroscience
Healthy, Cancer
The Effects of a Meditation Retreat on Healthy Volunteers and Cancer Patients: an fMRI Study
The purpose of this study is to evaluate the effects of a Zen meditation retreat (Sesshin) on psychophysiological parameters in healthy volunteers (regular meditators and non-meditators) and in cancer patients and to observe…
- Trial name
- Sesshin (NCT00878735)
- Testing
- Zen meditation
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Visual Neurosciences
Evaluation of Visual Parameters by Visual Evoked Potentials Captured by EEG
This project will be based on an approach that has already proven itself in the field of the development of low-level visual functions such as visual acuity, vernier acuity and contrast sensitivity (Norcia \& Tyler, 1985)…
- Trial name
- NCT05675852
- Testing
- 68-electrode electroencephalography with steady state visual evoked potentials
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Neuroscience of Dreaming, Healthy
The Impact of the Opiate Antagonist Naltrexone on the Emotional Valence of Dreams
In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.
- Trial name
- NCT02792140
- Testing
- Naltrexone
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bern
Chronic Pain, Manipulation
Comparison of the Effect of Spine Grade I and II Manipulation and a PNE Video on Brainwaves: Pilot Study
The purpose of this study is to determine the effect of the use of a pain neuroscience educational video instruction on brainwave activity and compare this to the effects of a grade I \& II PA spinal oscillations of the spine…
- Conditions
- Chronic Pain, Manipulation, Psychologic
- Trial name
- NCT04908670
- Testing
- Understanding Pain in less than 5 minutes, and what to do about it! https://www.youtube.com/watch?v=C_3phB93rvI, PA manipulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Healthy Subjects
The Impact of Pain Neuroscience Education on Physical Therapy Students' Knowledge, Attitudes, Beliefs, and Behaviors Towards Pain: A Randomized Controlled Trial
This study investigates the effect of pain neuroscience education (PNE) on pain knowledge, attitudes, beliefs and behaviors among undergraduate physiotherapy students in Jordan
- Trial name
- NCT06821022
- Testing
- Pain Neuroscience Education, Red Flags Education
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Low Back Pain, Recurrent
Effectiveness of a Pain Neuroscience Education Programme on Physical Activity in Patients With Chronic Low Back Pain
Proposing ways to effectively counter chronic low back pain through non-drug intervention is a major public health issue due to the prevalence and health costs of this condition.
- Trial name
- END-LC (NCT05840302)
- Testing
- Activity monitor, Questionnaire
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Montpellier
Chronic Low-back Pain
Effectiveness of Pain Neuroscience Education Compared to a Conventional Education for Patients With Chronic Low Back Pain
The hypothesis is that pain biology education, combined with a rehabilitation program, reduces disability to 3 months, compared to conventional spinal physiology education.
- Trial name
- EVAL-PNE (NCT04179708)
- Testing
- Pain Neuroscience Education, Conventional education
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Lille
Dissociation
Mechanistic Interventions and Neuroscience of Dissociation
The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people.
- Trial name
- MIND (NCT04670640)
- Testing
- Vibration, Breath Focus, No Distractions
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- Emory University
Cognitive Impairments Associated With Schizophrenia
Translational Neuroscience Optimization of GlyT1 Inhibitor
This is a Phase II, randomized, double-blind, placebo-controlled, cross-over POC study of stable patients with Schizophrenia or Schizoaffective disorder.
- Trial name
- NCATS (NCT01911676)
- Testing
- PF-03463275
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Neurosciences, Substance-Related Disorders
Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults
Emerging adults are a particularly vulnerable group for experiencing the immediate and potentially lifelong negative impacts of habitual cannabis use, and trends suggest that cannabis use disorder (CUD) will soon escalate in this…
- Conditions
- Neurosciences, Substance-Related Disorders, Behavior Problem
- Trial name
- NCT03944954
- Testing
- Marinol 10Mg Capsule TMS Real
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Michael J. Wesley, PhD
Breast Neoplasms, Survivorship
PI-targeted PNE+MI Compared to BIOMEDICAL Education in BCS
Breast cancer is the most frequently diagnosed cancer in women worldwide. An important portion of the breast cancer survivors will face chronic pain complaints.
- Conditions
- Breast Neoplasms, Survivorship, Pain, Chronic
- Trial name
- BCS-PI (NCT04730154)
- Testing
- Pain Neuroscience Education (PNE), Motivational Interviewing (MI), Biomedically-focused education
- Where
- 4 sites in Belgium
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Carpal Tunnel Syndrome (CTS)
Pain Neuroscience Education Versus Kinesio Tape on Functional Outcomes in Patients With Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) is one of the most common compressive neuropathies of the upper limb, characterized by pain, numbness, and functional impairment due to median nerve compression at the wrist.
- Trial name
- CP syndrome (NCT07539480)
- Testing
- group A: pain neuroscience education (PNE), group B: Patients receive Kinesio Taping
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Middle East University
Chronic Low-back Pain
Influence of Health Determinants on Physical Exercise Therapy With a Neurocognitive Focus on Chronic Low Back Pain
Protocols in which pain neuroscience education is combined with physical exercise have shown recently greater effectiveness in the treatment of low back pain in comparison to protocols based only on one of the two approaches.
- Trial name
- NCT04115670
- Testing
- Group of educational intervention on the neurophysiology of pain and physical exercises, Control group
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Universitària del Bages
Posttraumatic Stress Disorder
Cognitive Training for PTSD
Posttraumatic stress disorder (PTSD) is a chronic, disabling condition that occurs in a subgroup of individuals after experiencing traumatic stress, and is common in Veterans seeking mental health treatment at the VA.
- Trial name
- NCT03316196
- Testing
- COGENT COGNITIVE TRAINING, Non training computer condition
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Back Pain Lower Back Chronic
Effectiveness of a Psychoeducative Intervention on Patients With Cronic Low Back Pain
One of the treatment modalities currently available in this hospital to treat this type of patients with low back pain who present with chronic pain are the group sessions that are carried out to provide information to the…
- Trial name
- PNE (NCT03964389)
- Testing
- Pain Neuroscience Education" (PNE)
- Where
- Spain
- Volunteers
- 179 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Pain, Chronic, Pain, Postoperative
Efficacy of Pain Neuroscience Education and Pre-anesthetic Assessment in Reducing Levels of Anxiety, Stress and Pain in Patients Undergoing Elective Total Abdominal Hysterectomy (ENAH Study)
Through this quantitative, multivariate factorial experimental parallel randomized clinical trial, the investigators analyzed the effectiveness of pre-anesthetic assessment and pain neuroscience education in reducing anxiety…
- Conditions
- Pain, Chronic, Pain, Postoperative, Anesthesia, Surgery
- Trial name
- NCT05435508
- Testing
- Pain Neuroscience Education, Usual care
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Neurociencia Del Dolor
Chronic Musculoskeletal Pain
Virtual Human Technology for Patients With Chronic Pain
The experimental study compares three virtual human interviews of patients with chronic musculoskeletal pain: Emotional disclosure and brain, emotional disclosure only, basic information control.
- Trial name
- NCT04349033
- Testing
- Emotional Disclosure and Brain Education, Emotional Disclosure Only, Pain Information Control
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Wayne State University
Language, Epilepsy
Computational Neuroscience of Language Processing in the Human Brain
Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings…
- Trial name
- NCT05222594
- Testing
- Behavioral tasks during intracranial monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Fibromyalgia
Therapeutic Neuroscience Education in Individuals With Fibromyalgia
The aim of this study was to investigate the effects of Therapeutic Neuroscience Education (TNE) in individuals with Fibromyalgia (FM).
- Trial name
- NCT05435807
- Testing
- Therapeutic Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Pamukkale University