Clinical trials: Neuroscience Approach
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Whiplash Injuries
Shifting Away From Pain: a Neurocognitive Approach in Treatment of Whiplash
The broad aim of this study is to investigate the effect of a modern neuroscience approach, which combines education on pain neuroscience with cognition-targeted exercise therapy and stress management, on brain structure and…
- Trial name
- NCT04077619
- Testing
- Modern pain neuroscience approach, Usual care physiotherapy
- Where
- Belgium
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Ghent
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Whiplash
Modern Pain Neuroscience Applied to Chronic Pain in Patients With Chronic Whiplash Associated Disorders
Modern pain neuroscience has advanced our understanding of chronic whiplash associated disorders (WAD). Previous studies have shown the importance of central sensitization, characterized by hypersensitivity of the somatosensory…
- Trial name
- NCT03239938
- Testing
- Modern pain neuroscience approach, Usual care evidence-based physiotherapy
- Where
- 3 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Vrije Universiteit Brussel
Interstitial Cystitis, Bladder Pain Syndrome
Biopsychosocial and Conventional Approach in Bladder Pain Syndrome
The aim of the present study is to compare the effects of biopsychosocial and conventional approach on symptom severity, pain parameters (pain intensity and pain cognitions), disability, psychological distress and quality of life…
- Trial name
- NCT05155384
- Testing
- Pain Neuroscience Education, Relaxation exercises, Cognition target exercise
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Chronic Spinal Pain
Pain Neuroscience Education Combined With Cognition-targeted Motor Control Training
Chronic spinal pain (CSP) includes chronic low back pain, failed back surgery, chronic whiplash associated disorders, chronic non-traumatic neck pain, etc.
- Trial name
- NCT02098005
- Testing
- usual care evidence-based physiotherapy, modern neuroscience approach
- Where
- 3 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- University Ghent
Chronic Neck Pain, Persistent Neck Pain
The Effects of Neuroscience-Based Exercise
The aim of this study is to examine the effects of neuroscience-based exercise approaches on pain, disability and gait parameters in individuals with non-specific chronic neck pain.
- Conditions
- Chronic Neck Pain, Persistent Neck Pain, Neuroscience Approach
- Trial name
- NBE (NCT05788263)
- Testing
- neuroscience based aproach
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fatih Tekin
Violence, Domestic, Stress Related Disorder
Applied Social Neuroscience: the Building Resilience Among Women Project
Intimate partner violence (IPV) is the most common and alarming form of violence against women, affecting up to 25% of all women in Catalonia.
- Conditions
- Violence, Domestic, Stress Related Disorder, Depressive Disorder
- Trial name
- BRAW (NCT03623555)
- Testing
- Trier Social Stress Test, Salivary cortisol
- Where
- Spain
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Ximena Goldberg
Labor Pain and Anxiety
Pain Neuroscience-Based Education for Labor Pain in Pregnant Women
Fear of labor pain and negative cognitive patterns are among the key psychological determinants that influence the childbirth experience.
- Trial name
- NCT07902947
- Testing
- Impact of Education
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bilecik Seyh Edebali Universitesi
Chronic Non-specific Neck Pain
Effects of Physiotherapy Approaches on Biopsychosocial Outcomes in Chronic Non-Specific Neck Pain
Chronic non-specific neck pain (CNSNP) is a widespread musculoskeletal condition leading to pain, disability, and impaired quality of life.
- Trial name
- NCT07784504
- Testing
- Structured Exercise Program, Sensorimotor Training, Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul Medipol University Hospital
Aphasia, Broca, Aphasia, Wernicke
Remote Neurobased Approach to Aphasia Therapy
The purpose of this study is the development and validation of an evidence-based mobile application, based on the core premises of Intensive Language-Action Therapy (ILAT) for aphasia, for the training and improvement of chronic…
- Conditions
- Aphasia, Broca, Aphasia, Wernicke, Aphasia, Fluent, Aphasia, Nonfluent
- Trial name
- RNAAT (NCT05274360)
- Testing
- Mobile evidence-based aphasia therapy, Conventional aphasia rehabilitation
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Institute for Bioengineering of Catalonia