Clinical trials: Neurosciences
Major Depressive Disorder
Testing the Neuroscience of Guided Learning in Depression
Major depression is a prevalent and impairing illness. To better understand the basic science and treatment of depression, the investigators study the behavioral and brain processes associated with learning in depression and how…
- Trial name
- NCT03203954
- Testing
- Standard Learning, Guided Learning: Instructed statistics, Guided Learning: Changing statistics
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Motoric Cognitive Risk Syndrome, Cognitive-Motor Interaction
Laser-Based Map Tests in Motoric Cognitive Risk Syndrome
This study aims to evaluate the validity and reliability of neuroscience-based visual laser feedback map tests in individuals with Motoric Cognitive Risk Syndrome (MCRS).
- Conditions
- Motoric Cognitive Risk Syndrome, Cognitive-Motor Interaction, Sensorimotor Performance
- Trial name
- NCT07572942
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Balikesir University
Low Back Pain
Additional Effect of Pain Neuroscience Education to Spinal Manipulative Therapy in Chronic Low Back Pain
Objectives: The primary objective will be to investigate the additional effect (immediate and after one-month follow up) of pain neuroscience education (PNE) to Spinal Manipulative Therapy (SMT) on primary outcomes of pain…
- Trial name
- NCT03356886
- Testing
- Spinal Manipulative Technique, Pain Neuroscience Education
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- University of Sao Paulo
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Low-back Pain, Catastrophizing Pain
The Effect of Combining Pain Neuroscience Education and Transcranial Direct Current Stimulation on Pain Catastrophizing, Kinesiophobia, and Pain in Patients With Chronic Low Back Pain
Recent literature has shown that individuals with persistent chronic pain often exhibit altered cognitive, affective, and sensorimotor behaviors despite a full recovery of peripheral structural injury.
- Conditions
- Chronic Low-back Pain, Catastrophizing Pain, Kinesiophobia
- Trial name
- NCT05571215
- Testing
- Transcranial Direct Current Stimulation, Pain Neuroscience Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- High Point University
Post Intensive Care Syndrome
Multi-sensory Intervention Room Application (MIRA) Device in the NSICU
The purpose of this research study is to determine the safety, feasibility, and efficacy of a device, MIRA, on the physical, mental, and cognitive health of Neurosciences Intensive Care Unit (NSICU) patients.
- Trial name
- NCT06509815
- Testing
- MIRA
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rotator Cuff Injuries
A Pilot Randomized Trial of Pain Neuroscience Education in the Rehabilitation After Arthroscopic Rotator Cuff Repair
The aim of this study was to evaluate the effects of a 8-week pain neuroscience education programme compared to a biomedical education programme on the rehabilitation of patients who undergo arthroscopic rotator cuff repair.
- Trial name
- NCT04522934
- Testing
- Pain Neuroscience Education, Biomedical Education
- Where
- Chile
- Volunteers
- 29 people
- Sponsor
- Universidad Católica del Maule
Cognitive Training, Transcranial Direct Current Stimulation
Brain Research and Integrative Neuroscience Network for COVID-19
The aim of the experimental study is to investigate two interventions for the management of cognitive symptoms resulting from long COVID. Participants will be randomly assigned into two interventions. 1.
- Trial name
- BRAINN (NCT06517706)
- Testing
- Combination of tDCS (device) with cognitive training (behavioral), Categorization Program
- Where
- Cyprus
- Volunteers
- 38 people
- Sponsor
- University of Cyprus
Carpal Tunnel Syndrome
Effectiveness of Desensitisation and Pain Neuroscience Education in Patients With Carpal Tunnel Syndrome With Nosiplastic Pain
The aim of our study was to determine the effectiveness of desensitisation and pain neuroscience education in a group of patients with mixed phenotype pain (neuropathic and nosiplastic).
- Trial name
- NCT06635213
- Testing
- Desensitisation, Pain neuroscience education
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kutahya Health Sciences University
Acute Neurological Injury, Emotional Distress
Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a Neuroscience…
- Trial name
- NCT05157880
- Testing
- Recovering Together
- Where
- United States
- Volunteers
- 388 people
- Sponsor
- Massachusetts General Hospital
Archery, Physiotherapy and Rehabilitation
The Effect of Neuroscience-Based Exercise Training on Shooting Performance and Neuromuscular Performance in Archers
Archery is a sport that demands sport-specific motor performance, emphasizing fine motor control, postural stability, balance, and concentration skills.
- Conditions
- Archery, Physiotherapy and Rehabilitation, Muscle Activity, Visual Rehabilitation
- Trial name
- NCT07051577
- Testing
- Exercise Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Istinye University
Chronic Pain, Educational Problems
Pain Neuroscience Education in Students
This study was designed to evaluate the effect of a 70-minute Pain neuroscience education (PNE) session on physiotherapy students' knowledge of pain and their beliefs and attitudes about the treatment of patients with chronic…
- Trial name
- NCT04007679
- Testing
- Pain neuroscience education
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Low Back Pain
Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain
The purpose of this study is to evaluate the effects of combining Pain Neuroscience Education (PNE) with spinal manipulation for individuals suffering from chronic low back pain.
- Trial name
- LHC-LBP (NCT07639216)
- Testing
- Pain Neuroscience Education (PNE), Spinal Manipulation (SM)
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Centro Universitário Augusto Motta
Whiplash Injuries
Shifting Away From Pain: a Neurocognitive Approach in Treatment of Whiplash
The broad aim of this study is to investigate the effect of a modern neuroscience approach, which combines education on pain neuroscience with cognition-targeted exercise therapy and stress management, on brain structure and…
- Trial name
- NCT04077619
- Testing
- Modern pain neuroscience approach, Usual care physiotherapy
- Where
- Belgium
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Ghent
Misophonia, Emotion Dysregulation
Identifying the Optimal Neural Target for Misophonia Interventions
Misophonia, the inability to tolerate certain repetitive aversive sounds that are common, is gaining recognition as a debilitating condition. It is not a well-understood condition and there are no known treatments.
- Trial name
- NCT04348591
- Testing
- Cognitive Restructuring, neurostimulation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Healthy Subjects
The Impact of Pain Neuroscience Education on Physical Therapy Students' Knowledge, Attitudes, Beliefs, and Behaviors Towards Pain: A Randomized Controlled Trial
This study investigates the effect of pain neuroscience education (PNE) on pain knowledge, attitudes, beliefs and behaviors among undergraduate physiotherapy students in Jordan
- Trial name
- NCT06821022
- Testing
- Pain Neuroscience Education, Red Flags Education
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Fibromyalgia, Fibromyalgia Syndrome
Effectiveness of AI-Guided Exercise and Pain Neuroscience Education for Fibromyalgia (FIBROIA)
This randomized controlled trial will evaluate the effectiveness of a 12-week, home-based telerehabilitation program for adults with fibromyalgia (FM) combining AI-guided exercise with Pain Neuroscience Education (PNE).
- Trial name
- FibroIA (NCT06672419)
- Testing
- AI-Guided Exercise and Pain Neuroscience Education, Enhanced Usual Care for Fibromyalgia
- Where
- 2 sites in Chile, Colombia
- Volunteers
- 50 people
- Sponsor
- Instituto Neurociencia Del Dolor
Covid19, Neurologic Manifestations
Evaluation of Biological Response to SARS-COV2 (COVID-19) in Patients With Pre-existing Neurological Disease or Newly Neurological Symptoms (BIO-COCO-NEUROSCIENCES)
Patients with neurological or psychiatric symptoms or pre-existing disease will be sampled (blood for serum and DNA or saliva for DNA) at inclusion and at M6 (blood) and M12 (blood) depending on their pathology.
- Conditions
- Covid19, Neurologic Manifestations, Psychiatric Manifestations
- Trial name
- NCT04568707
- Testing
- blood sample
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fibromyalgia (FM), Chronic Low Back Pain (CLBP)
Pain Neuroscience Education for Chronic Pain
Chronic pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, with a high prevalence in Spain (25.9%) and an average duration of 6.83 years, highlighting its significant health…
- Conditions
- Fibromyalgia (FM), Chronic Low Back Pain (CLBP), Chronic Pain
- Trial name
- PNE (NCT07693998)
- Testing
- Therapeutic Exercise and Education in Pain Neuroscience
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- University of Valencia