Clinical trials: Neurosurgery
Ambulatory Surgery, Laparoscopy
Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit.
- Conditions
- Ambulatory Surgery, Laparoscopy, Shoulder Impingement Syndrome, Ovarian Cysts
- Trial name
- Herko (NCT04142203)
- Testing
- 23 h surgery
- Where
- Finland
- Volunteers
- 993 people
- Sponsor
- Kuopio University Hospital
Brain Tumor, Brain Metastases
Re-craniotomy and Complications After Elective Neurosurgery
This study is a prospective cohort study to find the incidence of re-craniotomy and predictive factors. The secondary outcomes are to find the incidence of major non-neurological complications and predictive factors.
- Conditions
- Brain Tumor, Brain Metastases, Brain Cancer, Brain Neoplasms
- Trial name
- NCT03910556
- Testing
- Propofol
- Volunteers
- 439 people
- Sponsor
- Chiang Mai University
Acute Kidney Injury
Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension
The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it
- Trial name
- NCT01554345
- Testing
- vitamin E +Selenium
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Symptomatic Lumbar Disc Herniation, Symptomatic Grade I Lumbar Spondylolisthesis
Neurosurgery Patient Outcomes in Treating Spinal Disorders
The creation of a multi-center cooperative research group encompassing academic and community-based spinal practices . . .
- Trial name
- Neuropoint SD (NCT01220921)
- Testing
- Lumbar Discectomy, Single-level lumbar fusion
- Where
- 13 sites in United States, Canada
- Volunteers
- 198 people
- Sponsor
- Greenwich Hospital
Diaphragm Issues, Neurosurgery
Post-neurosurgical Respiratory Muscle Dysfunction
Respiratory muscle dysfunction may contribute to the development of postoperative pulmonary complications. However, it prevalence in patients receiving neurosurgery is largely unknown.
- Conditions
- Diaphragm Issues, Neurosurgery, Pulmonary Complication
- Trial name
- NCT05951114
- Testing
- Maximum inspiratory/Expiratory manoeuvre for patients can follow the order
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Sanbo Brain Hospital
Postoperative Delirium
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anesthesia (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
- Trial name
- NCT06115031
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 696 people
- Sponsor
- Samsung Medical Center
Blood Pressure
Multidisciplinary Study to Verify Blood Pressure Documentation and Response to Titration of Intravenous Medications
This study is an observational, non-randomized, study that will examine the variability in blood pressure (BP) response to intravenous (IV) vasoactive medications when BP is continuously sampled versus real-world BP sampling.
- Trial name
- VERBATIM (NCT06253780)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Cerebral Tumors
Confocal Laser Endomicroscopy (CLE) During Medically Induced Neurosurgery in Craniobasal and Glioma Tumours
Purpose of the study is to answer the question whether confocal laser endomicroscopy (CLE, also named 'optical biopsy') might improve the results of medically necessary neurosurgery to prove practicability, safety and…
- Trial name
- Cleopatra (NCT02491827)
- Testing
- Cellvizio mini laser probe
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charalampaki, Cleopatra, M.D.
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Minimally Invasive Techniques, Neurosurgical Procedures
Cranio-spinal Neurosurgical Approaches
The goal of this observational study is to learn how different cranio-spinal surgical approaches work and how much anatomical exposure each technique provides in donated human cadaver specimens.
- Conditions
- Minimally Invasive Techniques, Neurosurgical Procedures, Cadaveric Training
- Trial name
- Neuro_SURGEM (NCT07287462)
- Testing
- Standardized cranio-spinal neurosurgical approaches performed on donated cadaveric specimens to assess surgical exposure, feasibility, anatomical variation, and selected new techniques.
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pituitary Adenoma
OCT-angiography as a Pronostic Marker for Visual Impairment in Patients Undergoing Neurosurgery for Compressive Macroadenoma : a Prospective Study.
The aim of the study is to assess accurancy of OCT angiography as a pronostic marker for patients undergoing neurosurgery for compressiver macroadenoma as compared with visual acuity, visual field and OCT.
- Trial name
- FIRST (NCT04074642)
- Testing
- Neurosurgery
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Patients Treated at the Neurosurgery Department
Patient Registry of the Neurosurgery Department
The investigators record all indications, treatments and outcomes from patients treated at the Neurosurgery Department. Trial with surgical intervention
- Trial name
- patregNCH (NCT01628406)
- Testing
- Treatment at the neurosurgery departement
- Where
- Switzerland
- Volunteers
- 24,000 people
- Sponsor
- University of Zurich
Electroencephalography
EEG Characteristics of Different Sedation Depths in Neurosurgery Patients
Gliomas are the most common primary intracranial malignancy, and behavioral experiments in patients with supratentorial gliomas under sedation have shown potential neurological abnormalities; however, these behavioral experiments…
- Trial name
- NCT04365777
- Testing
- OAA/S=5, OAA/S=3, OAA/S=1
- Where
- 2 sites in China
- Volunteers
- 42 people
- Sponsor
- Beijing Tiantan Hospital
Recurrent Glioblastoma
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)
The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of…
- Trial name
- OptimalTTF-2 (NCT04223999)
- Testing
- Skullremodeling surgery, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Anders Rosendal Korshøj
Aging
Large-scale Multi-omics Analysis of Cerebrospinal Fluid
The aim of this study is to explore the role of cerebrospinal fluid (CSF) biomarkers in aging and neurodegenerative diseases.
- Trial name
- NCT06636201
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Essential Tremor, Parkinson's Disease
Neurotransmitter Measurements Using (WINCS) During Deep Brain Stimulation Neurosurgery
In this study, the investigators will monitor extracellular neurotransmitter levels using a probe that is able to perform real time electrochemical detection during deep brain stimulation surgery.
- Conditions
- Essential Tremor, Parkinson's Disease, Dystonia
- Trial name
- NCT01705301
- Testing
- WINCS
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Glioblastoma Multiforme
Dendritic Cell Cancer Vaccine for High-grade Glioma
A randomised, open-label, 2-arm, multi-centre, phase II clinical study with one group receiving standard therapy with Temozolomide, radiotherapy, and Trivax; and a control group receiving standard therapy with Temozolomide and…
- Trial name
- GBM-Vax (NCT01213407)
- Testing
- Trivax, Temozolomide, Surgery, Radiotherapy, Temozolomide, Surgery, Radiotherapy
- Where
- 8 sites in Austria
- Volunteers
- 87 people
- Sponsor
- Activartis Biotech
Quality of Life
Endoscopic Perfusion Utilizing ICG Fluorescence Technology
The main objective of the study is to evaluate the efficacy of indocyanine green (ICG) endoscopy to evaluate tissue perfusion during endoscopic neurosurgery.
- Trial name
- ICG (NCT02383628)
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- University of Pittsburgh
Glioma, Glioblastoma
Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions
This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system…
- Conditions
- Glioma, Glioblastoma, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT04047264
- Testing
- Microdialysis, Magnetic Resonance Imaging, Computed Tomography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Neurosurgery
Correlation of PaCO2 to the Inspired and Expired Oxygen Gradient
The purpose of this study is to evaluate whether a correlation exists between the partial pressure of carbon dioxide existing within arterial blood and the gradient between inhaled and exhaled fractions of oxygen.
- Trial name
- O2 Fraction (NCT01513213)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Swedish Medical Center