Clinical trials: Neurosurgery
Anesthesia, Spinal, Neurosurgery
Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery
The goal of this pilot clinical trial is to test the feasibility of conducting a randomized controlled trial that will examine the use of ropivacaine in the spinal anesthesia for patients undergoing elective 1- or 2-level lower…
- Conditions
- Anesthesia, Spinal, Neurosurgery, Ropivacaine, Bupivacaine
- Trial name
- SASS (NCT05824338)
- Testing
- Spinal anesthesia for lumbar surgery: ropivacaine, Spinal anesthesia for lumbar surgery: bupivacaine, General anesthesia for lumbar surgery
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Fraser Health
Brain Injury, Neurosurgery
Electrocorticographic Monitoring of Brain Retraction Injury (EMBRI)
A single centre IDEAL Stage 1 feasibility study using novel electrophysiological recording techniques in adult participants undergoing neurosurgery.
- Conditions
- Brain Injury, Neurosurgery, Brain Ischemia
- Trial name
- EMBRI (NCT06409806)
- Testing
- ECOG Array
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Diaphragm Issues, Neurosurgery
Post-neurosurgical Respiratory Muscle Dysfunction
Respiratory muscle dysfunction may contribute to the development of postoperative pulmonary complications. However, it prevalence in patients receiving neurosurgery is largely unknown.
- Conditions
- Diaphragm Issues, Neurosurgery, Pulmonary Complication
- Trial name
- NCT05951114
- Testing
- Maximum inspiratory/Expiratory manoeuvre for patients can follow the order
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Sanbo Brain Hospital
Postoperative Pain, Neurosurgery
Incidence, Risk Factors and Impact of Significant Pain in Patients Undergoing Neurosurgery
The proposed study intends to evaluate incidence of postoperative pain after neurosurgery. This study is likely to help in understanding of the magnitude of this problem in our country and inform about possible predictors which…
- Trial name
- NCT05264012
- Testing
- Neurosurgery
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Rehabilitation, Neurologic Disorder
The Experience in Neurorehabilitation Setting: a Qualitative Study
In this exploratory qualitative study with a hermeneutic phenomenological approach, we will describe and understand the experience of treatment and hospitalization in hospitalized people suffering from stroke, multiple sclerosis…
- Conditions
- Rehabilitation, Neurologic Disorder, Stroke, Parkinson Disease
- Trial name
- NURSEXPERIENCE (NCT06264037)
- Testing
- semi structured interview
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Laryngoscopy, Intubation
Effect of Lidocaine Sprayed for Attenuating Hemodynamic Response During Laryngoscopy and Intubation
The goal of this clinical trial is to to evaluate the efficacy of lidocaine sprayed at the laryngeal inlet combined with the endotracheal tube cuff compare with intravenous lidocaine on the hemodynamic response to laryngoscopy…
- Conditions
- Laryngoscopy, Intubation, Hemodynamics, Neurosurgery
- Trial name
- NCT06226532
- Testing
- lidocaine spray, Intravenous Lidocaine
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Neurosurgery
Superficial Cervical Plexus Block for Postoperative Chronic Pain
The incidence of postoperative chronic pain after craniotomy is high. Postoperative chronic pain seriously affects patient's quality of life. Compound local scalp nerve block is a good choice for analgesia after craniotomy.
- Trial name
- NCT05108337
- Testing
- Superficial cervical plexus block, Control group
- Where
- 2 sites in China
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Neurologic Complication, Neurosurgery
The Potential Impact of Clindamycin on Neurosurgery Patients.
A prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy to assess its effect on neurological complication in relation…
- Trial name
- NCT06068673
- Testing
- Clindamycin 600 mg, standard regimen
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Damanhour University
Neurosurgery, Neuro-Oncology
Intraoperative Hyperspectral Imaging for Fluorescence Guided Surgery in Low Grade Gliomas
The purpose of this study is to obtain images of brain tumours during surgery using a new type of surgical camera. The study will assess how the information obtained from the images during surgery matches the removed tissue.
- Conditions
- Neurosurgery, Neuro-Oncology, Brain Tumor
- Trial name
- Neuro-qFHSI (NCT05397574)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Neurosurgery, Neurovascular
Intra-operative Hyperspectral Imaging in Neurosurgery
Brain surgery operations include brain tumour removal and blood vessel procedures. Each year in the UK, approximately 70,500 patients are diagnosed with a brain tumour, 5,000 of whom undergo surgery.
- Conditions
- Neurosurgery, Neurovascular, Neuro-Oncology
- Trial name
- NeuroHSI (NCT05294185)
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- King's College London
Neurosurgery, Intervention
Pharmacokinetic and Pharmacodynamic Modelling of Norepinephrine in Patients Under Target Controlled Infusions (TCI) for Anaesthesia
Currently, administration of norepinephrine diluted at 5 µg/ml bolus or continuous infusion is common during sympatholysis hypotension of TCI following the elimination of hypovolemia or anesthetic overdosage.
- Trial name
- NOR-PHARM (NCT03454204)
- Testing
- Pharmacokinetic
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Orthopedic Surgery, Neurosurgery
Distribution of Medication Disposal Packets - Acute Opioid Prescribing
Many prescription opioids following surgery are left unused and are at risk of being misused or diverted. Encouraging proper disposal is important, yet motivating this behavior remains challenging as patients must understand the…
- Conditions
- Orthopedic Surgery, Neurosurgery, Surgery, Opioid Use
- Trial name
- NCT05169281
- Testing
- Medication Disposal Packet
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- University of Pennsylvania
Venous Thromboembolism, Neurosurgery
Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A Multicenter, Prospective, and Cohort Study
- Conditions
- Venous Thromboembolism, Neurosurgery, Risk Assessment
- Trial name
- NCT05860790
- Testing
- Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Pain, Postoperative, Neurosurgery
Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy
Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space occupying lesions, spinal stenosis, disc herniation, injuries, etc.
- Trial name
- NCT04153396
- Testing
- The Treatment group, The Control group
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Beijing Tiantan Hospital
Informed Consent, Health Literacy, Risk, Spinal Puncture, Neurosurgery
Communicating Risks: Consent for Lumbar Puncture
The goal of this randomized control trial is to compare the effect of visual aids on the recall of probabilistic risks in healthy participants.
- Trial name
- NCT05717465
- Testing
- Anatomy diagrams, Standard informed consent
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Anti-epileptic Prophylaxis in Intracranial Neurosurgery
Comitial Prophylaxis in Neurosurgery in Patients Who Have Undergone Intracranial Surgery Programmed Supratentorial Surgery (Exeresis or Biopsy) Between 2019 and 2022
JUSTIFICATION Anti-epileptic prophylaxis has long been a systematic practice for supra-tentorial intracranial surgeries. Since 2021, European guidelines no longer recommend this prophylaxis and practices have evolved.
- Trial name
- PRO-CON (NCT05670860)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
Patients Undergoing Neurosurgery
The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery
This study aims to find an excellent drug in terms of hemodynamic stability when comparing the propofol and remifentanil with the combined use of remimazolam and remifentanil.
- Trial name
- NCT05164146
- Testing
- propofol, remimazolam
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Ambulatory Surgery, Laparoscopy
Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit.
- Conditions
- Ambulatory Surgery, Laparoscopy, Shoulder Impingement Syndrome, Ovarian Cysts
- Trial name
- Herko (NCT04142203)
- Testing
- 23 h surgery
- Where
- Finland
- Volunteers
- 993 people
- Sponsor
- Kuopio University Hospital
Neurosurgery
Driving Pressure in Neurosurgery
The effect of driving pressure (DP)-guided positive end expiratory pressure (PEEP) on early postoperative pulmonary ventilation is to be determined for patients undergoing neurosurgery.
- Trial name
- DPNS (NCT04421976)
- Testing
- PEEP
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Capital Medical University
Intracranial Infections, Ventriculitis
The Clinical Character，Risk and Prognosis of Post-neurosurgical Intracranial Infection With Different Pathogens.
Intracranial infection is one of the common clinical complications after neurosurgery, especially after external cerebrospinal fluid drainage.
- Conditions
- Intracranial Infections, Ventriculitis, Meningitis, Gram-Positive Bacterial Infections
- Trial name
- NCT04917380
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine