Clinical trials: Neurotrophic Keratitis
Neurotrophic Keratitis
A Study of STSP-0902 Ophthalmic Solution in Healthy Subjects
This trial is a Phase I clinical study to evaluate the safety, tolerability, and pharmacokinetic (PK) characteristics of STSP-0902 ophthalmic solution in healthy subjects following single and multiple administrations.
- Trial name
- NCT06597422
- Testing
- STSP-0902 ophthalmic solution
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Corneal Disease, Neuropathy
QST for Corneal Nerve Function
This study is designed to learn more about the impact different types of stimuli, such as heat, cold and vibration, can have on ocular pain response. This is called quantitative sensory testing (QST).
- Conditions
- Corneal Disease, Neuropathy, Dry Eye Disease, Neurotrophic Keratitis
- Trial name
- NCT05758753
- Testing
- Quantitative Sensory Test
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Autoimmune Diseases, Dry Eye
Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease
Single-site, open label pilot study of 20 autoimmune patients diagnosed with dry eye demonstrating via the proparacaine challenge some peripheral corneal pain component.
- Conditions
- Autoimmune Diseases, Dry Eye, Neurotrophic Keratitis
- Trial name
- MNK (NCT06964269)
- Testing
- Acthar Gel 80 UNT/ML Injectable Solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Dry Eye, Neurotrophic Keratitis
DOMPE -MT Neurotrophic Keratitis
TITLE: Toyos Clinic / A Phase 4 Study to Assess Longer Duration of Treatment with Cenegermin in Moderate to Severe Dry Eye-Associated Neurotrophic Keratitis
- Trial name
- NCT06947850
- Testing
- Cenegermin Ophthalmic Solution [Oxervate]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Sjogren's Syndrome, Dry Eye
Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye
In this study the investigators plan to enroll three groups of patients: non-Sjogren's dry eye, Sjogren's dry eye and controls. The study has the following primary goals: 1.
- Conditions
- Sjogren's Syndrome, Dry Eye, Neurotrophic Keratitis
- Trial name
- IIR (NCT06364657)
- Testing
- Eye Exam
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neurotrophic Ulcer, Neurotrophic Keratitis
OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate
Neurotrophic keratitis (NK) is a condition where the cornea, or clear outer covering of the eye, has reduced sensation due to a variety of reasons.
- Conditions
- Neurotrophic Ulcer, Neurotrophic Keratitis, Neurotrophic Corneal Ulcer, Neurotrophic Keratoconjunctivitis
- Trial name
- NCT04573647
- Testing
- Cenegermin-Bkbj 0.002% Ophthalmic Solution [OXERVATE]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sight Medical Doctors PLLC