Clinical trials: Neutrophil Activation
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ischemic Stroke
Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure
Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50%…
- Trial name
- CLOTSAFE (NCT06530927)
- Testing
- 3D rotational digital tomography, Atomic Force Microscopy, Micro-Computertomography
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Lung Injury
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
Seriously ill patients may develop a complication called acute lung injury (ALI), a form of inflammation in which lung tissue is filled by fluid containing white blood cells called neutrophils.
- Trial name
- NAP (NCT01532024)
- Testing
- Microdose of NAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Wegener's Granulomatosis
Study of One Protein Implicated in Wegener Disease
The investigators recently showed an abnormal expansion of NK-like CD4+ T cells in Wegener's granulomatosis (WG), mainly in the diffuse vasculitis presentation.
- Trial name
- DAP12WEGENER (NCT01167491)
- Testing
- Physiopathology Endpoint Classification
- Where
- France
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukocytosis, Triglycerides
Acute High Fat Bulletproof Coffee vs Black Coffee on Metabolism, Inflammation and Cognitive Function in Healthy Adults
This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.
- Conditions
- Leukocytosis, Triglycerides, Cognitive Function, Inflammatory Response
- Trial name
- NCT04307979
- Testing
- High-fat coffee, Black coffee
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Decompression Sickness, Endothelial Dysfunction
Exercise and Repetitive Diving
SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.
- Conditions
- Decompression Sickness, Endothelial Dysfunction, Neutrophil Activation, Venous Gas Emboli
- Trial name
- NCT02118207
- Testing
- Aerobic running exercise
- Where
- 2 sites in United States, Croatia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Split
Decompression Sickness, SCUBA Diving
High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation
The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving.
- Trial name
- NCT02064361
- Testing
- High intensity exercise
- Where
- 2 sites in United States, Croatia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Split
Cystic Fibrosis
Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation
The purpose of this study to investigate the effect of sulforaphane from macerated broccoli sprouts in humans and to evaluate less invasive methods of assessing potential anti-inflammatory drugs in CF.
- Trial name
- NCT01315665
- Testing
- Broccoli sprouts
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center