Clinical trials: Neutrophil Extracellular Trap Formation
Acute Ischemic Stroke, Large Vessel Occlusion
Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel Occlusion
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as a standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Neutrophil Extracellular Trap Formation
- Trial name
- NCT07552610
- Testing
- Sivelestat sodium, Endovascular Thrombectomy
- Where
- 2 sites in China
- Volunteers
- 868 people
- Sponsor
- Xuanwu Hospital, Beijing
Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation
Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes
Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes The goal of this clinical trial is to evaluate of the involvement of Neutrophil extracellular traps in the evolution of…
- Conditions
- Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation, Anesthesia, Lidocaine Infusion
- Trial name
- NCT07207304
- Testing
- Anesthesia, Anesthesia induction with TCI, sevoflurane anesthesia
- Where
- Romania
- Volunteers
- 153 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Venous Thromboses, Thromboembolic Disease
Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE)
Thrombo-embolic venous diseases are represented by deep venous thrombosis and/or pulmonary embolism. In some patients with repeated thrombosis or occurrence of thrombosis in unusual sites, the etiological workup remains negative…
- Conditions
- Venous Thromboses, Thromboembolic Disease, Neutrophil Extracellular Trap Formation, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- CLODETTE (NCT05711173)
- Testing
- Additional blood sampling
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Neutrophil Extracellular Traps Formation
Neutrophil Extracellular Traps (NETs) Mediated Killing of Carbapenem-resistant Pseudomonas Aeruginosa.
Aim of the work: To determine the killing ability of neutrophils to ATCC 27853, carbapenem-resistant P. aeruginosa. To compare between the ability of ATCC 27853, carbapenem-resistant P. aeruginosa to induce NETs formation.
- Trial name
- NCT06441708
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Assiut University
Neonatal Respiratory Distress Syndrome, Inflammatory Response
Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS
An Exploratory Randomized double-arm controlled trial to evaluate the immunomodulatory effect of low versus high dose of Alveofact with or without Budesonide.
- Conditions
- Neonatal Respiratory Distress Syndrome, Inflammatory Response, Premature Lungs, Neutrophil Extracellular Trap Formation
- Trial name
- NCT06367881
- Testing
- Alveofact, Budesonide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Neutrophil Extracellular Trap Formation, Portal Vein Tumor Thrombosis
Neutrophil Extracellular Traps as a Biomarker to Predict Portal Vein Tumor Thrombosis in Patients With Hepatocellular Carcinoma
The aim of this study was to investigate whether NETs markers can enhance predict portal vein tumor thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical decision-making.
- Trial name
- NCT05040347
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 68 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis
Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
The aim of this study was to investigate whether NETs markers can enhance procoagulant activity and predict portal vein thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical…
- Conditions
- Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis, Liver Cirrhosis
- Trial name
- NCT05012501
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 79 people
- Sponsor
- The Affiliated Hospital of Qingdao University