Clinical trials: Neutrophils
Evaluation of Early Inflammatory Process in CKD
Studying the Relationship Between Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio With Inflammation and Proteinuria in Chronic Kidney Disease
Inflammation begins during early stages of CKD in which neutrophil counts are increased, whereas lymphocyte counts are decreased during inflammation.
- Trial name
- NCT03149068
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colonic Neoplasms
Double Blinded Randomized Clinical Trial of the Effect of Open Versus Laparoscopic Colectomy on Neutrophils in Patients With Colon Cancer
The purpose of this study is: to determine neutrophil activity in patients with colon cancer, to determine levels sFas, sFasL and IL - 17 in serum of healthy volunteers and colon cancer patients and establish its prognostic…
- Trial name
- NCT00860691
- Testing
- Therapeutic conventional colorectal surgery, Therapeutic laparoscopic colorectal surgery, Peripheral blood sampling and performing: ELISA test of sFas, sFasL, IL - 17 and Bursttest
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Neonatal Sepsis
Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
- Trial name
- NCT04800445
- Testing
- Salivary CRP
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psoriasis Vulgaris, Atopic Dermatitis
The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders
Pro-inflammatory cytokines are critically important drivers of inflammatory and autoimmune diseases and cytokine-targeted biologics have been transformative in the treatment of several inflammatory and autoimmune diseases.
- Conditions
- Psoriasis Vulgaris, Atopic Dermatitis, Ichthyosis Vulgaris
- Trial name
- NEUTROPRO (NCT04750161)
- Testing
- No intervention
- Where
- Ireland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Over the Age of 65, Admitted to the Trauma Service
Immunologic Function in the Elderly After Injury
The purpose of this research is to learn more about the function of the body's ability to fight infection when the immune response is activated when injury occurs, in the elderly population.
- Trial name
- NCT00447135
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Summa Health System
Healthy
Bioequivalence Study of ARQ 197 Amorphous and Crystalline Polymorphs A and B in Normal Healthy Volunteers
This is a bioequivalence study designed to compare three solid states of ARQ 197 in normal healthy volunteers using a randomized crossover design.
- Trial name
- NCT00658554
- Testing
- ARQ 197
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Healthy Volunteer
A Pharmacodynamic Study to Evaluate Neutrophil Distribution Kinetics and Function Following Single-Dose RoActemra/Actemra (Tocilizumab) in Healthy Volunteers
This Phase IV, single-blind , randomized, two-arm study will explore the pharmacodynamics effects of RoActemra/Actemra (tocilizumab) on neutrophil redistribution, function and survival in healthy subjects.
- Trial name
- NCT01991990
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Respiratory Infection
Netosis in Determination of Respiratory Infection Severity
The study aims to evaluate the prognostic value of alveolar and blood NETosis in patients under mechanical ventilation and treated for an acute low-respiratory tract infection.
- Trial name
- NETMINDERS (NCT04318691)
- Testing
- Blood sampling, Bronchoalveolar lavage
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Immunosuppression
Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis
Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit…
- Trial name
- NCT01976884
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Rheumatoid Arthritis
Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune disease characterized by synovial inflammation and joint destruction that follows a relapsing- remitting course.Disease activity assessment is important for rheumatoid arthritis management…
- Trial name
- NCT03617250
- Testing
- Disease Activity Score-28
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Volunteer
A Bioequivalence Study Of AG-013736 Tablets Under Fed Conditions In Healthy Volunteers
The purpose is to show that 5 mg Form IV tablet of AG-013736 produces similar drug concentrations in plasma compared to 5 mg Form XLI tablet of AG-013736 after oral dosing under fed conditions.
- Trial name
- NCT01020136
- Testing
- AG-013736
- Where
- Singapore
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cardiovascular Diseases
Search of Biomarkers of Mineralocorticoid Receiver Activity : the Value of Neutrophil Gelatinase Associated Lipocalin (NGAL)in Serum or Urine in Human
Aldosterone and its target the mineralocorticoid receptor are implied in development of cardiovascular disease such as arterial high blood pressure or cardiac failure.
- Trial name
- NCT02129621
- Testing
- Urinary and blood lipococalin levels determination, Spironolactone
- Where
- 3 sites in France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Corneal Neovascularization, Neutrophils
Correlation Between a Novel Subset of Neutrophil and Corneal Neovascularization.
The purpose of this study is to determine whether a novel subset of neutrophils is correlated with corneal neovascularization in the patients suffered from ocular chemical injury.
- Trial name
- NCT05659940
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Acute on Top of Chronic Liver Cell Failure
Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as a Prognostic Predictor Among Patients With Acute on Top of Chronic Liver Cell Failure
Acute on chronic liver failure (ACLF) is a clinical syndrome of sudden hepatic decompensation observed in patients with pre-existing chronic liver disease and associated with one or more extrahepatic organ failures and increased…
- Trial name
- ACLF (NCT06857682)
- Where
- Egypt
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periodontal Diseases
A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels
A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels.
- Trial name
- (1346) (NCT06875440)
- Testing
- CHX mouthwash
- Where
- Iran
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Healthy
Bioequivalence of Two Different Polymorphs of Dabigatran Etexilate in Healthy Male and Female Volunteers
To establish the bioequivalence of two polymorphs of dabigatran etexilate, polymorph I and polymorph II
- Trial name
- NCT02171481
- Testing
- Dabigatran etexilate polymorph II, Dabigatran etexilate polymorph I
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Covid-19
Covid-19: Possible Role of Neutrophil Extracellular Traps
The process by which neutrophils expel DNA together with various proteins to the outside, forming a network structure called Neutrophil Extracellular Traps (NETs) constitutes a particular cell death that involves the destruction…
- Trial name
- NETSINCOVID (NCT04412382)
- Testing
- NETosis markers
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Adenomyosis, Leiomyoma
New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma
Both pelvic masses and preoperative diagnosis of them have still continued as an important investigation subject. It is important to discriminate the diagnoses of leiomyoma and adenomyosis before operation especially among…
- Conditions
- Adenomyosis, Leiomyoma, Inflammation
- Trial name
- NCT02997787
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Endotoxemia
Ethnic Differences in the Inflammatory Response in Systemic Inflammation
The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.
- Trial name
- NCT00284869
- Testing
- LPS
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss
Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss
1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance; 2.
- Trial name
- NCT03735108
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai First Maternity and Infant Hospital