Clinical trials: Neutrophils
Cystic Fibrosis, Pulmonary
Real World Environmental Exposure Study With Healthy and Cystic Fibrosis Subjects
Cystic fibrosis (CF) is the most common autosomal recessive disease that leads to early mortality in Caucasians and affects around 7500 patients in France.
- Trial name
- ExpoCF (NCT06339450)
- Testing
- walk tours
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Cardiovascular Diseases
Search of Biomarkers of Mineralocorticoid Receiver Activity : the Value of Neutrophil Gelatinase Associated Lipocalin (NGAL)in Serum or Urine in Human
Aldosterone and its target the mineralocorticoid receptor are implied in development of cardiovascular disease such as arterial high blood pressure or cardiac failure.
- Trial name
- NCT02129621
- Testing
- Urinary and blood lipococalin levels determination, Spironolactone
- Where
- 3 sites in France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Acute Appendicitis
Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis
The goal of this prospective observational study is to evaluate the diagnostic accuracy of pro-adrenomedullin (Pro-ADM) in adults with acute appendicitis and compare its performance with conventional inflammatory biomarkers…
- Trial name
- PROADM-APP (NCT07889544)
- Testing
- Serum Pro-Adrenomedullin Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Acute Kidney Injury
Neutrophil Gelatinase Associated Liocalin in Predicting AKI in Coronary Artery Disease
The aim of this work is to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI in patients exposed to PCI.
- Trial name
- NCT03266367
- Testing
- Neutrophil gelatinase-associated lipocalin (NAGL)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy
Anti-platelet Effects of Colchicine in Healthy Volunteers
This is a pilot study. Volunteers will be given 1.8 mg (1.2 mg followed by 0.6 mg one hour later), 1.2 mg, or 0.6 mg of colchicine.
- Trial name
- NCT02140372
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Acute Kidney Injury, Heart Valve Diseases
Correlation of Brain and Thenar Muscle Oximetry During Cardiac Surgery With Parameters of Acute Kidney Injury
Identification of risk factors of acute kidney injury (AKI). It is hypothesized that there might be a correlation between brain oximetry, tissue saturation of thenar muscle and marker of AKI in blood - neutrophil…
- Trial name
- NCT02979275
- Testing
- Open heart surgery on cardiopulmonary bypass.
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Respiratory Infection
Netosis in Determination of Respiratory Infection Severity
The study aims to evaluate the prognostic value of alveolar and blood NETosis in patients under mechanical ventilation and treated for an acute low-respiratory tract infection.
- Trial name
- NETMINDERS (NCT04318691)
- Testing
- Blood sampling, Bronchoalveolar lavage
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke
Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure
Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50%…
- Trial name
- CLOTSAFE (NCT06530927)
- Testing
- 3D rotational digital tomography, Atomic Force Microscopy, Micro-Computertomography
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Zurich
COPD, Emphysema
Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to the lung in chronic obstructive pulmonary disease (COPD) and cause tissue destruction.
- Conditions
- COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT00147082
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Periodontitis, Diabetes Mellitus, Type 2
White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis
White blood cell membrane and surface structures are affected by the metabolic disorders and complications found in diabetes mellitus.
- Trial name
- DMS (NCT01848379)
- Testing
- ADT+FD, FD
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zentrum fuer Zahn-, Mund- und Kieferheilkunde
Wegener's Granulomatosis
Study of One Protein Implicated in Wegener Disease
The investigators recently showed an abnormal expansion of NK-like CD4+ T cells in Wegener's granulomatosis (WG), mainly in the diffuse vasculitis presentation.
- Trial name
- DAP12WEGENER (NCT01167491)
- Testing
- Physiopathology Endpoint Classification
- Where
- France
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Allogeneic Granulocyte Donation
Improving White Blood Cell Collection From Healthy Donors
Background: White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells.
- Trial name
- NCT01553214
- Testing
- Filgrastim, Dexamethasone
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
A Study of CCX168 in Japanese and Caucasian Healthy Adult Males
The objectives of the study will be to investigate the safety and pharmacokinetics of a single oral administration and a twice-daily multiple oral administration of CCX168 in Japanese healthy adult males; and to compare the…
- Trial name
- NCT05988008
- Testing
- CCX168
- Where
- Japan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Amgen
MMPs and NGAL in Ruptured and Non-ruptured Aneurysms
Matrix Metalloproteinases (MMPs),Neutrophil Gelatinase-associated Lipocalin (NGAL) Tissue and Plasma Levels and Aneurysms
An association between arterial aneurysms and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling.
- Trial name
- NCT02145533
- Where
- Italy
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Neutrophil-mediated Inflammatory Dermatoses, Inflammatory Dermatoses
Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
This study is to identify rare, disease-causing mutations of several rare neutrophil dermatoses. To identify associations between NMID and variants in the genome next generation sequencing, mainly whole exome sequencing, will be…
- Trial name
- NEUTROSKIN (NCT05732987)
- Testing
- Analysis of samples
- Where
- Switzerland
- Volunteers
- 3,370 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
White Blood Cells
Study of the Cell Response in the Tear Film After Overnight Contact Lens Wear
The purpose of this study was to count and analyze the white blood cells in tear samples collected from study participants following sleep.
- Trial name
- CORNWALL (NCT01379768)
- Testing
- Lotrafilcon A contact lens, Lotrafilcon B contact lens, Clear Care Cleaning and Disinfection Solution
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CIBA VISION
Healthy Smokers
Range of Neutrophil Response to 20,000 EU of Clinical Center Reference Endotoxin in Otherwise Healthy Smokers
Endotoxin is a component of outdoor air pollution, an air contaminant found in a number of different workplaces, and is even found in homes.
- Trial name
- NCT00753870
- Testing
- CCRE inhalation
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Burns
Relationship Between Neutrophil Function and Sepsis in Adults and Children With Severe Thermal Injuries
The study aims to validate neutrophil function, immature granulocyte and plasma free DNA levels as predictive diagnostic biomarkers of sepsis in burn patients.
- Trial name
- SIFTI-2 (NCT04693442)
- Testing
- taking of blood, urine and blood samples and objective scar assessment
- Where
- United Kingdom
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Systemic Lupus Erythematosus, Systemic Sclerosis
Neutrophil Extracellular Traps in Systemic Sclerosis
Systemic sclerosis (SSC) is a systemic disease characterized by limited or diffuse cutaneous sclerosis, microangiopathy, overproduction of autoantibodies and variable organ damage due to vasculopathy and/or fibrosis.
- Trial name
- NET-SSC (NCT03374618)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- CHU de Reims