Clinical trials: Neutrophils
Microscopic Polyangiitis (MPA)
Efficacy and Safety of Rituximab in the Treatment of Good Prognosis Microscopic Polyangiitis
The purpose of the study is to determine wether a rituximab-based treatment compared to standard therapy (glucocorticoid alone) in patients with microscopic polyangiitis without any bad prognosis marker increases the remission…
- Trial name
- RITUXGOPRO (NCT03920722)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ANCA Associated Vasculitis, Cardiovascular Diseases
ETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)
ANCA-associated vasculitis is an autoimmune disease that causes damage to blood vessels. This leads to organ damage with the number of organs affected and the severity of damage varying significantly between patients.
- Conditions
- ANCA Associated Vasculitis, Cardiovascular Diseases, Kidney Diseases
- Trial name
- SPARVASC (NCT05630612)
- Testing
- Sparsentan
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Edinburgh
Nasal Allergy
Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects
The purpose of this study is to see if the recruitment of a certain cell type (the alpha 4 integrin (CD49d) expressing neutrophil) during a nasal allergen challenge can be inhibited by pretreatment with an FDA approved…
- Trial name
- NCT03039101
- Testing
- Nasal lavage, Nasal allergen challenge, Epicutaneous skin testing
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mitchell Grayson
Hemodialysis Complication
Impact of Neutrophil Lymphocyte and Monocyte Lymphocyte Ratio on Chronic Kidney Disease Patients Outcome
The aim of this study is to establish NLR, MLR as a good predictors for outcome of CKD including hemodialysis and CKD stage (4-5) patients as regard inflammation, malnutrition and anemia on cardiovascular complication.
- Trial name
- NCT05887960
- Testing
- CBC and flow cytometry test for monocyte
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis
Algorithm for Predicting the Unfavorable Course of Sepsis in Children
A comprehensive strategy will be used to investigate the relationship and correlation between 4 diagnostically significant markers relevant for early diagnosis and prediction of complications and death in the development of…
- Trial name
- NCT05908162
- Testing
- Bood leukocyte subsets
- Where
- Belarus
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Asthma
GSK2190915 Neutrophilic Asthma Study
The purpose of this study is to investigate the effect on repeat doses of GSK2190915 in asthmatic patients with a high percentage of neutrophils in their sputum.
- Trial name
- NCT01471665
- Testing
- GSK2190915 100mg
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- GlaxoSmithKline
Healthy Women, Menstruation
The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise
The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40.
- Conditions
- Healthy Women, Menstruation, Resistance Exercise
- Trial name
- NCT06985420
- Testing
- Resistance exercise, Menstrual Cycle Phases
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Central Florida
ANCA-related Vasculitis
Clinical Relevance of Anti-Neutrophil Cytoplasm Antibody (ANCA)in Hospitalized Patients
Laboratory testing of Anti-Neutrophil Cytoplasm Antibody (ANCA) is used to confirm diagnosis of patients who have a high level of suspicion for ANCA-related vasculitis.
- Trial name
- NCT01238003
- Testing
- Interpretation of blood test results
- Where
- Israel
- Volunteers
- 380 people
- Sponsor
- Hillel Yaffe Medical Center
Purpura, Schoenlein-Henoch, Graft Versus Host Disease
Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases
OBJECTIVES: I. Determine whether there is prompt engraftment after autologous peripheral blood stem cell transplantation using filgrastim (G-CSF) mobilization in patients with life threatening autoimmune diseases. II.
- Conditions
- Purpura, Schoenlein-Henoch, Graft Versus Host Disease, Anemia, Hemolytic, Autoimmune, Rheumatoid Arthritis
- Trial name
- NCT00006055
- Testing
- anti-thymocyte globulin, cyclophosphamide, cyclosporine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fairview University Medical Center
Psoriasis, Atherosclerotic Cardiovascular Disease
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
Background: Psoriasis causes chronic inflammation in the body. Researchers want to see if a kind of vitamin B3 dietary supplement can help. This might lead to more treatment options.
- Conditions
- Psoriasis, Atherosclerotic Cardiovascular Disease, Obesity, Dyslipidemia
- Trial name
- NCT04271735
- Testing
- Niagen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications
The primary objective of this study will be to evaluate the drug-drug interaction potential of CCX168 with concomitant medications, as either a perpetrator or a victim, following oral administration of CCX168 to healthy…
- Trial name
- NCT06004947
- Testing
- CCX168, Midazolam, Celecoxib
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amgen
Lung Injury, Cardiopulmonary Bypass
Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality.
- Trial name
- NCT04296071
- Testing
- Research study
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sophia Koutsogiannaki
Granulomatosis With Polyangiitis, Microscopic Polyangiitis
An Observational Study of The Safety of MabThera/Rituxan (Rituximab) in Participants With Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis
This prospective observational study will evaluate the long-term safety of MabThera/Rituxan (rituximab) in participants with granulomatosis with polyangiitis (Wegener's) or microscopic polyangiitis.
- Trial name
- NCT01613599
- Testing
- Rituximab
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- Genentech, Inc.
SLE (Systemic Lupus), Systemic Sclerosis
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
This is an open clinical pharmacological translational Research Study, aiming to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of CD19 or CD19-BCMA CAR-T in patients with active SLE, SSc, AAV…
- Conditions
- SLE (Systemic Lupus), Systemic Sclerosis, ANCA Associated Vasculitis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT06548607
- Testing
- CD19 or CD19-BCMA CAR-T
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Coronary Thrombosis
Periprocedural Myocardial Infarction: the Role of Human Neutrophil Peptide-1 to 3
The aim of this study is to determine the role of human neutrophil peptide-1 to 3 in the occurrence of periprocedural myocardial infarction.
- Trial name
- NCT02591264
- Testing
- Blood sample
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hillel Yaffe Medical Center
ANCA Associated Vasculitis, Maintenance Therapy
Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis
This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is not inferior to that of patients…
- Trial name
- LEFAZAREM (NCT04737343)
- Testing
- Leflunomide, Azathioprine Tablets
- Where
- 4 sites in China
- Volunteers
- 114 people
- Sponsor
- Chinese SLE Treatment And Research Group
Hypertension in Pregnancy
Effect of Hydroxytyrosol on NLR, MLR, and SOD in Hypertensive Pregnant Women
The goal of this clinical trial is to evaluate whether hydroxytyrosol supplementation (10 mg/day for 4 weeks) is effective in improving inflammatory and oxidative stress markers in pregnant women diagnosed with hypertensive…
- Trial name
- HyPreg (NCT07074548)
- Testing
- Hydroxytyrosol
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Cystic Fibrosis
Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers
Inflammation clearly contributes to the progression of the cystic fibrosis (CF) lung disease, and administration of the anti-inflammatory agent high-dose ibuprofen retards the rate of decline of pulmonary function.
- Trial name
- NCT00531882
- Testing
- Pioglitazone, Simvastatin, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Peritoneal Dialysis-associated Peritonitis
Neutrophil Gelatinase-Associated Lipocalin (NGAL) Rapid Test (Colloidal Gold) Clinical Trial Protocol
According to the requirements of the "Technical Guidelines for Clinical Trials of In Vitro Diagnostic Reagents", the first registered product (hereinafter referred to as the assessment reagent) - Neutrophil Gelatinase-Associated…
- Trial name
- NCT05450523
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Qingdao HIGHTOP Biotech Co., Ltd.
Myocardial Ischemia
The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Ischemia reperfusion injury may be attenuated by HO-1 induction. Our previous data confirmed strong HO-1 induction in peripheral blood cells following heme arginate infusion in healthy humans.
- Trial name
- NCT02314780
- Testing
- Heme arginate 3mg/kg, Heme arginate 1mg/kg
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Martin Andreas, M.D.