Clinical trials: Newborn, Transient
Hereditary Anemias
Utility of Fibroscan in Estimating Hepatic Iron Concentration
In patients with hereditary anemias (e.g. thalassemias), defective red blood cells are produced due to an error in the genes, or DNA, that provide the instructions for their synthesis.
- Trial name
- NCT02067130
- Testing
- Fibroscan
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
TTN
The Effectiveness of Inhaled Salbutamol in the Management of Transient Tachypnea of the Newborn(TTN)
TTN is the most common respiratory disorder in the perinatal period, causing 40% of cases of respiratory distress after birth. Lung fluid absorption is initiated by beta-adrenergic agonists, such as endogenous steroids and…
- Trial name
- NCT07350421
- Testing
- Salbutamol (Albuterol), Normal Saline
- Where
- Syria
- Volunteers
- 1 people
- Sponsor
- Latakia University
Transient Tachypnea Newborn, Cesarean Delivery Affecting Fetus
Misoprostol Before Elective Caesarean Section for Decreasing the Neonatal Respiratory Morbidity
Neonatal respiratory distress may occur in either term or preterm newborns with a higher relative risk in preterm, and whether born vaginally or through caesarean section, but in a higher percentage after elective caesarean…
- Trial name
- NCT03031353
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Down Syndrome
Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21
Patients with trisomy 21 are in greater danger of developing caries. It has been hypothesized that adding silver nanoparticles to fluor varnishes could promote remineralization of the teeth.
- Trial name
- NCT01975545
- Testing
- Fluor varnish, Fluor varnish with nanoparticles
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Transient Hypothyroxinemia of Prematurity (THOP)
Study of Thyroid Hormones in Prematures
The investigators hypothesize that continuous infusion of 4 µg/Kg/day T4 with 30 µg/Kg/day oral potassium iodide (KI) for 42 days from birth will reduce by 30% or more (from an estimated 30% to 21%) the proportion of extremely…
- Trial name
- THOP2 (NCT02103998)
- Testing
- thryoid hormone T4 + oral potassium iodide (KI) for 42 days, D5W - 5% dextrose water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- New York Medical College
Patent Foramen Ovale, Stroke
Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO)
The primary objective of the study is to determine whether the STARFlex® septal closure system will safely and effectively prevent a recurrent embolic stroke/transient ischemic attack (TIA) and mortality in patients with a PFO…
- Conditions
- Patent Foramen Ovale, Stroke, Ischemic Attack, Transient
- Trial name
- NCT00201461
- Testing
- STARFlex septal closure system, Best medical therapy
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- NMT Medical
Patent Foramen Ovale
Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism
The primary objective of this study is to demonstrate the safety of the PFX Closure System when utilized for patients with patent foramen ovale (PFO) suffering from cryptogenic stroke, transient ischemic attacks or paradoxical…
- Trial name
- NCT00196027
- Testing
- PFX Closure System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cierra
Compare Between the Serum Level of Lcarnitine in HIE Cases and TTN
Measuring Serum Level of Total L Carnitine in HIE and TTN
It is a comparative prospective and observational study conducted at Neonatal Intensive Care Unit (NICU) in Assiut University Children Hospital.
- Trial name
- HIELcarnitine (NCT04546321)
- Testing
- serum L carnitine level measuring
- Volunteers
- 47 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (>6 hours of life).
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome
- Trial name
- NCT07344714
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Transient Tachypnea of the Newborn
Role of Salbutamol and Furosemide in TTN
to see the effects of slabutamol and IV furosemide in the treatment of transient tachypnea of newborn
- Trial name
- NCT03208894
- Testing
- Furosemide Injection
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Armed Forces Hospital, Pakistan
Transient Tachypnea of the Newborn, TTN
Lung Ultrasound to Diagnose Transient Tachypnea of the Newborn (TTN) Versus Respiratory Distress Syndrome (RDS) in Neonates
The investigators hypothesize that ultrasonography of the newborn lung can be used as an effective diagnostic tool in neonates ≥ 28 weeks gestation with early symptoms of respiratory distress.
- Conditions
- Transient Tachypnea of the Newborn, TTN, Respiratory Distress Syndrome, RDS
- Trial name
- NCT01517958
- Testing
- Respiratory Distress Group, Control Group
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Transient Tachypnea of the Newborn
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN)
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn: Randomized controlled trial to assess:
- Trial name
- NCT05006235
- Testing
- Epinephrine Inhalation Solution, Salbutamol, Saline Inhalants
- Volunteers
- 135 people
- Sponsor
- Ahmed Noaman
Diastolic Dysfunction, Neonatal Encephalopathy
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography
The goal of this single-centre longitudinal observational study is to create reference values for diastolic function parameters in neonates born at 35 weeks' gestation or above, and to assess the influence of pre-defined…
- Conditions
- Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
- Trial name
- DiFuSE (NCT06200519)
- Where
- Ireland
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University College Cork
Infant, Premature, Diseases, Infant, Newborn, Diseases
Pulmonary Function Using Non-invasive Forced Oscillometry
The purpose of this observational study is to measure pulmonary function in term and preterm infants with and without pulmonary disease including respiratory distress syndrome, bronchopulmonary dysplasia, transient tachypnea of…
- Conditions
- Infant, Premature, Diseases, Infant, Newborn, Diseases, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
- Trial name
- PUFFOR (NCT03346343)
- Testing
- Non-invasive forced airway oscillometry
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Transient Tachypnea of the Newborn
Reducing Respiratory Distress After Elective Caesarean Birth Through Knee-chest-flexion: a Randomized Controlled Trial
Planned caesarean birth is a risk factor for the development of neonatal respiratory distress commonly known as transient tachypnoea of the newborn.
- Trial name
- NCT06270823
- Testing
- Knee-to-chest-flexion manoeuvre
- Where
- Tanzania
- Volunteers
- 562 people
- Sponsor
- Kilimanjaro Clinical Research Institute
Spinal Cord Injuries
Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients
To investigate the clinical effect of detrusor botulinum toxin A (BoNT-A) injection on neurogenic detrusor overactivity (NDO) and renal function and to compare the difference of expressions of sensory receptors and nerve growth…
- Trial name
- NCT01682603
- Testing
- Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Transient Tachypnea of the Newborn
nHFOV Versus nCPAP in Transient Tachypnea of the Newborn
In this prospective, randomised clinical trial the investigators aim to assess if nasal high frequency oscillatory ventilation (nHFOV) could be used as the primary modality of respiratory support in late preterm and term infants…
- Trial name
- NCT03006354
- Testing
- nHFOV, nCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Heart Failure, Dilated Cardiomyopathy
PITA-HF: Feasibility, Safety, and Tolerability
Heart failure affects over 25 million people worldwide and nearly 7 million adults in the United States alone. Nearly 25% of patients with heart failure have worsened disease burden from dyssynchronous ventricular contraction due…
- Trial name
- NCT04159454
- Testing
- PITA
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Maternal Attachment, Breastfeeding
Reciprocal Mother-Infant Voice Exposure in the Neonatal Intensive Care Unit
This randomized controlled trial evaluates the effect of reciprocal maternal-infant voice exposure on maternal attachment and breastfeeding outcomes in a neonatal intensive care unit (NICU).
- Conditions
- Maternal Attachment, Breastfeeding, Transient Tachypnea of the Newborn, Neonatal Intensive Care Unit
- Trial name
- NCT07597954
- Testing
- Reciprocal Voice Exposure Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Biruni University