Clinical trials: Newborn Diseases
Tracheobronchomalacia, Tracheal Stenosis
Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis
It is not clearly understood what causes tracheobronchomalacia (weakening of the windpipe and airways) or tracheal stenosis (narrowing of the windpipe).
- Trial name
- NCT00705848
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
GNE Myopathy, Hereditary Inclusion Body Myopathy
International GNE Myopathy Patient Registry
GNE myopathy, an ultra-rare disease, is a severe progressive myopathy that typically presents in early adulthood as weakness in the distal muscles of the lower extremities and progresses proximally, leading to a loss of muscle…
- Trial name
- NCT04009226
- Testing
- Patient Registry
- Where
- United Kingdom
- Volunteers
- 430 people
- Sponsor
- Newcastle University
Funnel Chest
Evaluation of a New Model of Metallic Bar and Stabilizer for Use in MIRPE
Pectus excavatum (PE) is the most common deformity of the chest wall, occurring in approximately 1/1000 people. Currently, surgical treatment by minimally invasive technique is consolidating as preferred technique for the…
- Trial name
- NCT03087734
- Testing
- Implantation of new model of bar with oblique stabilizers, Implantation of regular bar with perpendicular stabilizers
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Long QT Syndrome
Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
This study will evaluate the effect of oral GS-6615 on QTc interval in healthy adults with dofetilide-induced QTc prolongation.
- Trial name
- NCT02365532
- Testing
- GS-6615, Dofetilide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Atopic Dermatitis (AD), Atopic Dermatitis (Eczema)
Clinical Trial to Evaluate the Efficacy and Safety of an Ozonated Oil in Atopic Dermatitis
This clinical trial is designed to evaluate the efficacy, safety, and tolerability of a topical ozonated vegetable oil formulation in paediatric patients with mild-to-moderate atopic dermatitis.
- Trial name
- NCT07744516
- Testing
- ozonated oil, non-ozonated oil
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Laboratorios Ozoaqua
LCA (Leber Congenital Amaurosis), RP (Retinitis Pigmentosa)
Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)
The purpose of this study is: To evaluate the safety of up to 3 additional courses of oral QLT091001 administered once daily for 7 days in subjects treated previously with a single 7-day course of QLT091001 in Study RET IRD 01 To…
- Trial name
- NCT01521793
- Testing
- QLT091001
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 27 people
- Sponsor
- QLT Inc.
Primary Congenital Glaucoma
The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma
Primary congenital glaucoma, which presents at birth or in infancy, if left untreated, may threaten vision. The incidence of congenital glaucoma varies among different geographic locations and ethnic groups.
- Trial name
- NCT01020721
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
OSA, Malocclusion
Changes of the Upper Airway Volume After Orthognathic Surgery
The aim of the present project is to analyze the impact from orthognathic surgery on the upper airway respiratory volume. The primary objective is comparison of differences in the in the airway changes due to maxillary movements…
- Conditions
- OSA, Malocclusion, Dentofacial Deformities
- Trial name
- NCT05060133
- Testing
- Orthognathic Surgery
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Duchenne Muscular Dystrophy (DMD)
Study of Eteplirsen in DMD Patients
The main objective of this study is to provide evidence of efficacy of eteplirsen (AVI-4658) in Duchenne muscular dystrophy (DMD) patients that are amenable to skipping exon 51.
- Trial name
- PROMOVI (NCT02255552)
- Testing
- eteplirsen
- Where
- 37 sites in United States
- Volunteers
- 109 people
- Sponsor
- Sarepta Therapeutics, Inc.
Alzheimer's Disease, Multiple Sclerosis
A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery
The purpose of this research project is to collect and store blood samples and clinical data. Researchers can then use the stored samples in future studies.
- Conditions
- Alzheimer's Disease, Multiple Sclerosis, Parkinson's Disease, Huntington's Disease
- Trial name
- NCT01592552
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Achondroplasia, Small for Gestational Age
Adaption and Testing of the Quality of Life in Short Stature Youth (QoLISSY) Questionnaire for Parents With Children From 0-4
The aim of the study is the adaption, implementation and validation of the instrument for the investigation of the short stature specific quality of life (QoLISSY) for children (age 0-4 years) with achondroplasia (ACH), Small for…
- Conditions
- Achondroplasia, Small for Gestational Age, Growth Hormone Deficiency
- Trial name
- NCT05603936
- Testing
- Questionnaire
- Where
- Germany
- Volunteers
- 168 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Dystrophic Epidermolysis Bullosa
A Follow-up Study to Evaluate the Efficacy and Safety of ALLO-ASC-DFU in ALLO-ASC-EB-101 Clinical Trial
This is an open-label follow up study to evaluate the safety for the subjects with ALLO-ASC-DFU treatment in phase 1/2 clinical trial(ALLO-ASC-EB-101) for 24 months.
- Trial name
- NCT03183934
- Testing
- ALLO-ASC-DFU
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Anterogen Co., Ltd.
Hematologic Malignancies
A Single-arm Safety Study of Transplantation Using Umbilical Cord Blood and Human Placental-derived Stem Cells From Partially Matched Related Donors in Persons With Certain Malignant Blood Diseases and Non-malignant Disorders
To investigate the safety of partially matched related human placental-derived stem cells (HPDSC) administered in conjunction with umbilical cord blood (UCB) stem cells from the same donor in subjects with various malignant or…
- Trial name
- HPDSC (NCT00596999)
- Testing
- UCB and HPDSC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Celgene Corporation
Aplasia Cutis Congenita
Genetic and Functional Analysis of Aplasia Cutis Congenital (ACC)
The goal of this research study is to identify genes and regulatory elements on chromosomes that cause ACC. The investigators also study tissue samples from patients to learn about the processes that lead to this disorder.
- Trial name
- ACC (NCT01630421)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- UConn Health
Spinal Muscular Atrophy
A Pilot Study of Biomarkers for Spinal Muscular Atrophy
The goal of this pilot study is to identify a marker or panel of markers in the blood or urine from a wide range of Spinal Muscular Atrophy (SMA) patients that segregates with measures of clinical severity.
- Trial name
- BforSMA (NCT00756821)
- Where
- 18 sites in United States, Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Congenital Heart Disease With Systemic Right Ventricle
Study of Adaptation of the Right Ventricle to Systemic Afterload
the first purpose of the study is to determine the adaptative mechanisms of right ventricle (RV) to systemic afterload, and the mechanisms of RV failure, in patients with congenital heart disease and subaortic RV, using cardiac…
- Trial name
- STARS (NCT02066506)
- Testing
- asymptomatic group, symptomatic group
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atopic Dermatitis
Dose-ranging Study of Nemolizumab in Atopic Dermatitis
Assess the efficacy of several subcutaneous doses of nemolizumab in moderate-to-severe atopic dermatitis (AD) subjects with severe pruritus receiving TCS, who were not adequately controlled with topical treatments.
- Trial name
- NCT03100344
- Testing
- Nemolizumab
- Where
- 67 sites in United States, Australia and 4 more
- Volunteers
- 226 people
- Sponsor
- Galderma R&D
Fetomaternal Transfusion
Effect of Placental Drainage of Fetal Blood at Cesarean Section on the Incidence of Feto-Maternal Transfusion
Study hypothesis: umbilical cord drainage of fetal blood after delivery of the infant would reduce the incidence of feto-maternal transfusion.
- Trial name
- NCT00470899
- Testing
- drainage of placenta of fetal blood
- Volunteers
- 86 people
- Sponsor
- Lester E. Cox Medical Centers
Premature Birth
Family Integrated Care (FICare) in Level II NICUs
In Alberta, nearly one in every twelve babies is born too soon (preterm). Preterm babies are at greater risk for breathing and feeding problems, as well as infections, than babies born on their due date (full term).
- Trial name
- FICare (NCT02879799)
- Testing
- Implement Family Integrated Care
- Where
- 10 sites in Canada
- Volunteers
- 765 people
- Sponsor
- University of Calgary
Fetal Growth Restriction, Small for Gestational Age at Delivery
Evaluation of HALP Score in Distinction Between FGR and SGA
Fetal Growth Restriction (FGR) and Small for Gestational Age (SGA) are two conditions that can happen when a baby doesn't grow as much as expected during pregnancy.
- Trial name
- NCT05814198
- Testing
- HALP score
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.