Clinical trials: Newborn Infant
Bronchopulmonary Dysplasia
Neurally Adjusted Ventilatory Assist vs Proportional Assist Ventilation
This study aims to assess whether neurally adjusted ventilatory assist or proportional assist ventilation is more effective in infants born prematurely with evolving or established bronchopulmonary dysplasia
- Trial name
- NCT02967549
- Testing
- NAVA, PAV
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- King's College London
Newborn, Yoga
The Effects of Mother-Baby Yoga and Baby Massage on Attachment and Sleep
Purpose: This study was conducted to examine the effects of mother-baby yoga and massage on mother-baby bonding and the baby's sleep.
- Conditions
- Newborn, Yoga, Mother-Infant Interaction, Sleep
- Trial name
- NCT06269458
- Testing
- Baby Massage, Monther-Baby Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Antalya Bilim University
Fetal Alcohol Spectrum Disorders
Nutritional Risk Factors for FASD in Ukraine
Interventional study randomizing pregnant women at two sites in Ukraine who have or have not already consumed moderate to heavy levels of alcohol in pregnancy to receiving a standard prenatal vitamin supplement with or without…
- Trial name
- NCT03782935
- Testing
- Prenatal multivitamin mineral supplement
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Oxidative Stress
Effect of Mother DHA Supplementation on Premature Newborn.
To date, the investigations in the field of the supplementation with DHA in premature babies have been focused on the study of neuronal and visual development, giving place to contradictory and ambiguous results, because they did…
- Trial name
- NCT01940640
- Testing
- DHA, control
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Respiratory Distress Syndrome In Premature Infants
Safety and Efficacy Study of the Draeger Babylog VN500 Device in HFOV Mode in VLBW Neonates
The purpose of this study is to determine the safety and effectiveness of the Babylog VN500 in high frequency oscillatory ventilation (HFOV) mode as a method for treating very low birth weight (VLBW) neonates requiring invasive…
- Trial name
- NCT02445040
- Testing
- Babylog VN500 in HFOV Mode
- Where
- 14 sites in United States
- Volunteers
- 225 people
- Sponsor
- Draeger Medical Systems, Inc.
Irritable Bowel Syndrome
Multicenter Observational Prospective Study to Describe Irritable Bowel Syndrome in the Russian Federation
Observational Prospective Study to Describe Irritable Bowel Syndrome in the Russian Federation
- Trial name
- ROMERUS (NCT03549143)
- Testing
- IBS
- Where
- 37 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Abbott
Cystic Fibrosis, Periodontitis
Cystic Fibrosis and Periodontal Diseases
The number of CF adults is increasing year after year (61.7% in 2021) confirming that patients are living longer. These data do not leave aside the desire to see CF patients "age well" considering of all the comorbidities linked…
- Conditions
- Cystic Fibrosis, Periodontitis, Gingivitis
- Trial name
- MucoParo (NCT06133335)
- Testing
- Periodontal examination
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Congenital Malformation
Pregnancy Environment and Newborn Malformations
Congenital malformations rate is about 3% in France. There are already 5 registries in France, covering about 16% of French births: Paris Registry, (about 38 000 births /year), Alsace Registry, (about 23 000 births/year)…
- Trial name
- PENEW (NCT01613638)
- Testing
- meconium samples + maternal self-questionnaire
- Where
- 11 sites in France
- Volunteers
- 1,657 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Antibiotic Stewardship, Neonatal Sepsis, Late-Onset
Vancomycin Reduction Practices (VRP) in the NICU
This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs).
- Conditions
- Antibiotic Stewardship, Neonatal Sepsis, Late-Onset, Vancomycin
- Trial name
- NCT06772675
- Testing
- External Facilitation
- Where
- 13 sites in United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Bronchopulmonary Dysplasia
Effect of Synchronized vs. Continuous HFNC Using NAVA on WOB in Infants With BPD
Patients will be randomized to begin the study with either NAVA-synchronized or continuous HFNC. Each patient will receive two 15-minute trials at different levels of continuous HFNC and two 15-minute trials at corresponding…
- Trial name
- NCT04274192
- Testing
- Synchronized HFNC at 6 liters per minute (LPM), Continuous HFNC at 6 liters per minute (LPM), Synchronized HFNC at 8 liters per minute (LPM)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Persistent Fetal Circulation, Persistent Pulmonary Hypertension of the Newborn
Nebulized MgSO4 in Persistent Pulmonary Hypertension of Newborn
The aim of this pilot randomized controlled blinded study is to evaluate the feasibility of using nebulized magnesium sulfate in the treatment of PPHN.
- Conditions
- Persistent Fetal Circulation, Persistent Pulmonary Hypertension of the Newborn, PPHN
- Trial name
- NebMag (NCT04328636)
- Testing
- Nebulized Magnesium Sulfate, Intravenous Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Sohag University
Cystic Fibrosis, Colorectal Cancer
Colorectal Cancer Screening in Cystic Fibrosis
This multi-center study will compare multi-target DNA and quantitative FIT stool-based testing to colonoscopy in individuals with Cystic Fibrosis (CF) undergoing colon cancer screening with colonoscopy.
- Conditions
- Cystic Fibrosis, Colorectal Cancer, Adenoma
- Trial name
- NICE-CF (NCT05362344)
- Testing
- Stool tests
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Induction of Labor Affected Fetus / Newborn
Obesity Study to Assess Induction of Labor
There are more and more pregnant women who are obese. It is very difficult for obese women to get into labor. That is why when women are obese, half are likely to need a Cesarean delivery(C-section).
- Trial name
- Obtainable (NCT03796416)
- Testing
- Misoprostol
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cystic Fibrosis
Study of Hepatic Glucose Production and De Novo Lipogenesis in Patients With Cystic Fibrosis
OBJECTIVES: I. Determine the amount of hepatic glucose production derived from gluconeogenesis and glycogenolysis in the post-absorptive state in patients with cystic fibrosis. II.
- Trial name
- NCT00014781
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sepsis of the Newborn
Role of 'Pentoxifylline and or IgM Enriched Intravenous Immunoglobulin in the Treatment of Neonatal Sepsis'
The investigators aim is to investigate whether adjuvant Pentoxifylline , IgM enriched IVIG or Pentoxifylline plus IgM-enriched IVIG reduced mortality from Neonatal sepsis.
- Trial name
- NCT01006499
- Testing
- Pentoxifylline, pentaglobin
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Cystic Fibrosis
A Study to Evaluate Safety, PK and PD of FDL169 in Cystic Fibrosis Subjects
This is a multicenter, randomized, placebo-controlled, dose-escalation study. Enrollment is planned to occur at approximately 14 global sites. Approximately 24 subjects with CF.
- Trial name
- NCT03093714
- Testing
- FDL169
- Where
- 14 sites in Australia, Czechia and 2 more
- Volunteers
- 27 people
- Sponsor
- Flatley Discovery Lab LLC
Congenital Hyperinsulinism
18FluoroLDOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism
The goal of this project is to determine the role of FDOPA/PET as a pre-operative diagnostic imaging procedure for differentiating focal and diffuse forms of congenital hyperinsulinism and locating focal lesions in the pancreas…
- Trial name
- DOPA PET (NCT04205604)
- Testing
- 18F-Fluoro Dopa Imaging
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Miguel Pampaloni
Cystic Fibrosis
NPD Measurement in Infants
Nasal Potential Difference measurements (NPD) have been performed in Israel since 1996. NPD measurements are used to assess the voltage across nasal epithelium, which correlates with the transport of sodium and chloride across…
- Trial name
- NCT00564304
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Cystic Fibrosis
A Study to Investigate the Safety and Tolerability of Single and Multiple Ascending Doses of KIT2014 in Healthy Subjects
This is the first-in-human study with KIT2014 designed to provide safety, tolerability and pharmacokinetic data in healthy volunteers.
- Trial name
- NCT06659757
- Testing
- KIT2014
- Where
- Australia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kither Biotech Srl
Patent Ductus Arteriosus
Acetaminophen vs Indomethacin in Treating hsPDA
The purpose of this study is to see if acetaminophen (Tylenol) is as effective as indomethacin in closing patent ductus arteriosus in premature infants.
- Trial name
- NCT03537144
- Testing
- Indomethacin, Acetaminophen
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Tennessee
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