Clinical trials: Newborn Infant
Patent Ductus Arteriosus After Premature Birth
Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants
Patent ductus arteriosus (PDA), the most common cardiovascular complication of prematurity, is associated with higher mortality and morbidities in extremely low gestational age neonates (ELGANs, < 27+0 weeks).
- Trial name
- NCT05340582
- Testing
- Acetaminophen Injection, Ibuprofen 20 mg/mL oral suspension or Ibuprofen lysine 10 mg/mL injection solution (Neoprofen), Sodium chloride 0.9% injection
- Where
- 9 sites in Australia, Canada and 2 more
- Volunteers
- 310 people
- Sponsor
- Mount Sinai Hospital, Canada
Sepsis, Neonatal
Comparison Between Split Septum and Mechanical Valve Needleless Connector in Preterm Babies
The goal of this clinical trial study is to compare the effectiveness between split septum and mechanical valve needleless connector in very preterm babies (or under 1500 grams) The main questions it aims to answer are: What is…
- Trial name
- NCT06414174
- Testing
- Split septum needleless connector, Mechanical valve needleless connector
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Cystic Fibrosis, Inflammation
Connexin Genotypes in Cystic Fibrosis
Background: There is wide variety in lung disease phenotype for the delta F508 (homozygous) genotype. A leukocyte driven inflammation is most important for the pathogenesis of pulmonary disease in CF.
- Trial name
- NCT04242420
- Testing
- Genotyping, Lung function, Microbiology
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 300 people
- Sponsor
- University Childrens' Hospital (Zentrum für Kinderheilkunde des Universitätsklinikum Bonn)
Infant and Young Child Feeding
Standardized Application of Feeding Evaluations Using SMART Tool
Premature and medically complex infants have delayed development of oral feeding skills, leading to prolonged hospitalization, costs, and family stress.
- Trial name
- SAFEST (NCT07136610)
- Testing
- SMART Tool
- Where
- 14 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- Wake Forest University Health Sciences
Neurodevelopment, Neonatal Mortality
Newborn Kit to Save Lives and Brains in Kenya
Each year, more than 3 million neonatal deaths occur worldwide and greater than 200 million children under the age of 5, almost all in low- and middle-income countries, are not fulfilling their developmental potential.
- Trial name
- NCT02208960
- Testing
- Neonatal Kit, Neonatal Stimulation
- Where
- Kenya
- Volunteers
- 2,294 people
- Sponsor
- The Hospital for Sick Children
Newborn Morbidity, Pain
Epidemiology of Painful Procedures in Neonates
Sick or premature neonates are exposed to frequent painful and stressful procedures during their stay in neonatal intensive care units.
- Conditions
- Newborn Morbidity, Pain, Procedures, Intratracheal Intubation
- Trial name
- EPIPPAIN (NCT01346813)
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Hôpital Armand Trousseau
Cystic Fibrosis
Tobramycin Administered by eFlow Rapid Nebulizer: Pharmacokinetic Study
This study assesses the aerosol delivery characteristics (measured by nebulization time, serum and sputum tobramycin pharmacokinetic parameters) and safety of tobramycin administered for inhalation by PARI eFlow rapid electronic…
- Trial name
- NCT00420836
- Testing
- Tobramycin
- Volunteers
- 20 people
- Sponsor
- Novartis
Cystic Fibrosis
Macrolide Antibiotic Therapy for Patients With Cystic Fibrosis
The purpose of this study is to evaluate whether Biaxin (clarithromycin) improves sputum abnormalities, lung function, and overall feeling of well-being in people with cystic fibrosis (CF).
- Trial name
- NCT00205634
- Testing
- Biaxin ( clarithromycin)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University
Cystic Fibrosis
Choline Nutritional Status Of Children With Cystic Fibrosis X-Sectional Study
Cystic fibrosis (CF) is the most common lethal, inherited disorder among Caucasians. Choline is an essential vitamin and as a methyl donor is critically needed to support the normal metabolism.
- Trial name
- NCT01150136
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Birth Trauma
The Effect of Stress Ball and Expressive Touch Application
Purpose: The study will be conducted to examine the effects of stress ball and expressive touch application on pain, mobilization and breastfeeding during episiotomy repair.
- Trial name
- NCT06740734
- Testing
- Stress ball, Expressive touch applications
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Mine Gokduman Keles
Amount of Breast Milk
Care Based on the Lactation Management Model Provided to Mothers With Babies in the Intensive Care Unit
Using breast stimulating techniques (skin-to-skin contact, relaxation exercises, breast massage, nipple stimulation, hot application, etc.) stimulates the secretion of milk and increases its amount.
- Trial name
- NCT06125548
- Testing
- Lactation Management Model
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mersin University
Intrauterine Growth Restriction, Premature - Weight 1000g-2499g or Gestation of 28-37weeks
Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies.
- Conditions
- Intrauterine Growth Restriction, Premature - Weight 1000g-2499g or Gestation of 28-37weeks, Neurodevelopmental Disorder, EEG; Spikes, Centrotemporal, Epilepsy of Childhood
- Trial name
- NCT01942525
- Testing
- aEEG
- Where
- Austria
- Volunteers
- 156 people
- Sponsor
- Medical University of Vienna
Apnea of Prematurity, Intermittent Hypoxemia
The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants
The aim of this proposal is to characterize the acute effect of early postnatal sound exposure on neuronal maturation of the respiratory control regions of the brain in preterm infants.
- Conditions
- Apnea of Prematurity, Intermittent Hypoxemia, Bradycardia
- Trial name
- NCT05298748
- Testing
- Womb sound recordings
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Case Western Reserve University
Breast Feeding
Clinical Trial of Immediate Skin to Skin Contact at Birth Early vs. Immediate (CPPITLH)
SUMMARY: Human lactation is a simple, cost-effective strategy contributing to infant and maternal mortality control. Skin to skin contact (SSC), is an immediate postpartum period strategy that has proven to benefit the initiation…
- Trial name
- CPPITLH (NCT02687685)
- Testing
- Skin to skin contact immediate, skin to skin contact early
- Where
- Colombia
- Volunteers
- 300 people
- Sponsor
- Universidad de la Sabana
Social Support, Spouse
The Effect of Newborn Basic Care Training Provided to Prospective Fathers Via a Website on Self-Efficacy and Perceptions of Spousal Support During Pregnancy
Support programs and training should be provided to parents by healthcare professionals, especially neonatal nurses and midwives, in line with these basic newborn care needs.
- Conditions
- Social Support, Spouse, Self Efficacy, FATHER
- Trial name
- ENBC-T (NCT07248215)
- Testing
- Web Group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Parents of Healthy Newborns, Pregnant Women and Partners
French Cross-cultural Adaptation of the Iowa Infant Feeding Attitude Scale (IIFAS)
Our study will consist of two parts: Part 1: Cross-cultural adaptation of the Iowa Infant Feeding Attitude Scale (IIFAS) among postpartum mothers and co-parents in France and assessment of its psychometric properties Part 2…
- Trial name
- FRENCH IIFAS (NCT07620704)
- Where
- France
- Volunteers
- 930 people
- Sponsor
- University Hospital, Clermont-Ferrand
Prematurity
Creating a Calmer NICU: Optimizing Growth and Brain Development in Preterm Infants
Infants born preterm can spend months in the neonatal intensive care unit (NICU) where they experience stressful but essential procedures. Untreated stress is associated with altered brain development.
- Trial name
- NCT04911452
- Testing
- Calmer
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Lung Diseases, Bronchopulmonary Dysplasia
Antecedents of Bronchopulmonary Dysplasia
To identify risk factors for bronchopulmonary dysplasia/chronic pulmonary disease of prematurity and to estimate proportions of this group of disorders attributable to antenatal risk factors, perinatal events, and neonatal care…
- Trial name
- NCT00005293
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Mobile Application Based Learning
Effectiveness of Module Based Learning and Mobile Application Based Learning Regarding Facility Based Newborn Care Among Nursing Students
The study evaluates the effectiveness of Module based learning and Mobile application based learning regarding Facility based newborn care among nursing students.Total 70 Nursing students were randomly allocated to MBL and MABL…
- Trial name
- NCT03224663
- Testing
- Module based learning, Mobile application based learning
- Volunteers
- 70 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Premature Birth of Newborn
Enteral Feeding and Early Gut Colonization of Preterm Infants
The aim of this study is to evaluate the potential role of the enteral feeding systems on the bacterial colonization of premature infants during their NICU admittance and its evolution after 2 years, which is the age when the…
- Trial name
- PRECOL (NCT02502916)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
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