Clinical trials: Newly-diagnosed Crohn's Disease
Crohn's Disease, Ulcerative Colitis
Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease, which includes both Crohn's disease and ulcerative colitis, is a disease of the gastrointestinal tract leading to symptoms of abdominal pain, diarrhea, and growth disturbance.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Protein Metabolism
- Trial name
- NCT00586352
- Testing
- stable isotope infusions
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Indiana University
Crohn Disease
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both.
- Trial name
- CAMEO (NCT05781152)
- Testing
- Anti-TNF therapy
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,270 people
- Sponsor
- Connecticut Children's Medical Center
Newly-diagnosed Crohn's Disease
Development and Validation of a Nomogram for Predicting Surgery in Newly-diagnosed Crohn's Disease: a Retrospective Cohort Study
A majority of patients with Crohn's disease undergo surgery during the disease course. We aimed to develop an easily available nomogram to predict the risk of surgery at diagnosis.
- Trial name
- NCT06457035
- Testing
- immunosuppressant
- Volunteers
- 490 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Chrohn's Disease
Efficacy of Top-down Therapy With Mirikizumab Versus Standard of Care With Azathioprine in Patients With Newly Diagnosed, Moderate-to-severe Crohn's Disease
The choice of drug therapy for Crohn's disease depends on several factors, such as the severity of the condition, the sections of the bowel affected, or the patient's previous treatment history.
- Trial name
- NCT07659353
- Testing
- Mirikizumab, Azathioprine (AZA)
- Where
- Germany
- Volunteers
- 320 people
- Sponsor
- University Hospital Schleswig-Holstein
Crohn Disease
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Newly Diagnosed Active Crohn Disease
Dysbiosis can be rectified by several methods: antibiotics, prebiotics, probiotics, dietary modulation, and fecal microbiota transplantation.
- Trial name
- ALTER-CD (NCT06890650)
- Testing
- Fecal Microbial Transplantation, Crohns disease exclusion diet
- Where
- 6 sites in India
- Volunteers
- 168 people
- Sponsor
- All India Institute of Medical Sciences
Crohn Disease
The Effect of Oral Polymeric Diet Enriched With TGF-beta 2 (Modulen) on Clinical Response and Mucosal Healing in Adult Patients With Newly Diagnosed Crohn's Disease
The aim of this study is to evaluate prospectively a possible effect of an oral polymeric diet enriched with TGF-beta 2 (Modulen) as compared to Budesonide (one of the commonly accepted treatments for Crohn's disease) on clinical…
- Trial name
- NCT04233463
- Testing
- Modulen, Budesonide
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Crohn's Disease
The Vitamin D in Pediatric Crohn's Disease
The purpose of this study is to determine if vitamin D as an adjuvant therapy can improve the outcome (i.e. fewer relapses) and the quality of life, including levels of physical activity, in children with newly diagnosed Crohn's…
- Trial name
- ViDiPeC (NCT02186275)
- Testing
- Vitamin D3: 3000 or 4000 UI/day then 2,000 UI/day, Vitamin D3 800 UI/day then 800 UI/day
- Where
- 10 sites in Canada
- Volunteers
- 25 people
- Sponsor
- St. Justine's Hospital
Crohn's Disease
Retrospective Data Analysis in Crohn's Disease
The purpose of this study is to identify prognostic parameters about efficacy of Mesalazine in recently diagnosed patients with Morbus Crohn by retrospective data collection.
- Trial name
- Crohn 2 (NCT01363427)
- Where
- 16 sites in Germany
- Volunteers
- 161 people
- Sponsor
- Ferring Pharmaceuticals
Crohn Disease
Observational Prospective Study to Identify Intestinal Microbial Profiles in Newly Diagnosed Crohn's Disease Patients
Crohn's disease (CD), a chronic inflammatory disease affecting the intestine, is characterised by a relapsing course. In 25% of cases, the onset of this disease occurs in childhood.
- Trial name
- NCT06324591
- Testing
- Collection biological sample and analysis
- Where
- 3 sites in Austria, Italy
- Volunteers
- 30 people
- Sponsor
- Meyer Children's Hospital IRCCS
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
Safety and Efficacy of Capsule FMT in Treatment-naïve Patients With Newly Diagnosed Chronic Inflammatory Diseases
PURPOSE: The main purpose is to explore clinical efficacy and safety associated with capsule FMT (cFMT) performed in newly diagnosed, untreated patients with rheumatic and gastrointestinal chronic inflammatory diseases (CIDs).
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Crohn Disease
- Trial name
- FRONT (NCT04924270)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Odense University Hospital
Inflammatory Bowel Diseases
Butyrate in Pediatric Inflammatory Bowel Disease
The first prospective randomised placebo-controlled study in the IBD pediatric population was conducted to evaluate the effectiveness of oral sodium butyrate as add-on therapy in IBD.
- Trial name
- NCT05456763
- Testing
- sodium butyrate
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Crohn's Disease
Prospective Evaluation of a Scoring System in Patients Newly Diagnosed With Crohn's Disease
The purpose of this study is to prospectively evaluate a scoring system to predict a mild course of disease in patients newly diagnosed with Crohn's disease.
- Trial name
- PROGNOS (NCT02193048)
- Testing
- This study will evaluate a new clinical scoring system in patients receiving routine treatment
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- Ferring Pharmaceuticals