Clinical trials: Next Generation Sequencing
Breast Cancer, Measurable Residual Disease
Exploratory Research on Constructing a Computational Biological Model Based on NGS for MRD After Breast Cancer Surgery
This study will include 80 subjects after radical breast cancer resection, collect blood samples of the above subjects, observe and quantify the characteristic changes of cfDNA in the blood of breast cancer subjects after…
- Trial name
- NCT06595966
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Squamous Cell Carcinoma
Detection of Circulating Tumor DNA in p16- Locally Advanced Head Neck Squamous Cell Carcinoma
Locally advanced head and neck squamous cell carcinoma (LAHNSCC) is a heterogeneous disease, associated with a poor prognosis and no improvement in overall survival for years.
- Trial name
- PERSO-NECK (NCT03896412)
- Testing
- Detecton of circulating tumor DNA
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Henri Becquerel
Fractures, Bone, Infections
Clinical Metagenomic of Post-traumatic Infections
Treatment of fracture related infection is challenging and often lead to failure in such situation that carry a high health cost burden.
- Trial name
- METADIAG (NCT05770856)
- Testing
- Metagenomic sequencing
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Breast Cancer, Metastatic Breast Cancer
Next Generation Sequencing-based "Oncochip" for Therapeutic Decision in Metastatic Breast Cancer. Study SHARP
The present trial clinical proposes to randomize patients with cancer metastatic disease of the breast progressing on standard therapy to receive a treatment selected from 4 "targeted" drugs (a MEK kinase inhibitor, an mTOR…
- Trial name
- NCT06727357
- Testing
- Chemotherapy
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- European Institute of Oncology
Lymphoma
Enhancing Diagnosis in Chronic B-cell Lymphoproliferative Disorders Using Next-Generation Sequencing
To enhance the diagnosis of unclassifiable, non-CLL B-LPDs using next-generation sequencing technology.
- Trial name
- ENABLE-NGS (NCT03344809)
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Solid Tumors, Metastatic Disease
CPCT-02 Biopsy Protocol
A major challenge for researchers in cancer care is to expedite the development of new therapeutics and the Center for Personalized Cancer Treatment (a collaboration of the Dept.
- Trial name
- CPCT-02 (NCT01855477)
- Testing
- Histological biopsy procedure
- Where
- Netherlands
- Volunteers
- 6,927 people
- Sponsor
- Foundation CPCT
Lung Cancer Stage III, Mutation
Neoadjuvant Umbrella Trial for Patients With Unresectable Stage III NSCLC Harboring Rare Mutations.
This umbrella trial directed by next generation sequencing (NGS) includes patients with treatment-naive unresectable stage III non-small-cell lung cancer (NSCLC).
- Trial name
- NUMER (NCT06563999)
- Testing
- Sunvozertinib, Crizotinib, Pralsetinib
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Cryptogenic Organizing Pneumonia, Idiopathic Interstitial Pneumonias
Screening Microorganism of Cryptogenic Mechanical Pneumonia Through Next Generation Sequencing to Lung Tissue Fluid
The etiology of cryptogenic organizing pneumonia (COP)was not clear, but previous studies have shown that in some patients, some pathogen could be detected in bronchoalveolar lavage fluid (BALF), and may be one of the causes of…
- Trial name
- COPandNGS (NCT04511884)
- Testing
- Next-generation sequencing
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Neoplasms, Lung Neoplasms
CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician Choice
Registry participants with advanced malignancy or myelodysplasia will have a sample of their tumor or tissue analysed for genetic alterations using next generation sequencing (NGS) performed in a lab that has been certified to…
- Conditions
- Neoplasms, Lung Neoplasms, Colon Neoplasms, Breast Neoplasms
- Trial name
- N1 (NCT02900248)
- Testing
- Provider determined
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- CureOne
HIV Infection
Pathogen Detection in HIV-infected Children With Non-malarial Febrile Illnesses Using Metagenomic Sequencing
In Uganda, 130,000 children (0-14 years of age) were living with HIV in 2018. Last year, nearly 450 infants acquired HIV every day; most of them during childbirth and these are at extremely high risk of dying in the first two…
- Trial name
- PHICAMS (NCT05085158)
- Where
- Uganda
- Volunteers
- 138 people
- Sponsor
- Makerere University
Lung Neoplasms, Carcinoma Non-small-cell Lung
A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing
The investigators are doing this research to see if they can use small tissue samples or fluid to develop a test that will determine if the tissue samples are related or not related to each other.
- Trial name
- NCT02705404
- Testing
- Multifocal Tissue Banking
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Renal Cell Carcinoma, Renal Tumor
Non-Invasive Diagnostics of Small Renal Masses
NiSAR is a Ph.D. study and consists of three substudies. Renal cancer is one of the most deadly urologic malignancies and accounts for 900 new cases and 300 deaths per year.
- Trial name
- NISar (NCT03667885)
- Testing
- Blood sample, urine sample, Multi planar MRI
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Odense University Hospital
Pulmonary Infection
mNGS for Detection of Pathogens for Pulmonary Infection
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases.
- Trial name
- NCT03798925
- Testing
- None Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Microbial Colonization, Burns
Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology
The purpose of this investigation is to better understand the wound microbiome in burn wounds and the role it plays in outcomes and complications related to treatment.
- Trial name
- NCT05275335
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Von Willebrand Disease
Molecular and Clinical Profile of Von Willebrand Disease in Spain
The present Project is a third phase of the previous PCM-EVW-ES Project (Batlle et al. Thromb \& Haemost 2015) with the aim of its extension, further analysis with an innovation development in the field of von Willebrand disease…
- Trial name
- PCM-EVW-ES (NCT02869074)
- Testing
- VWF gene analysis
- Where
- Spain
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Spanish Society of Thrombosis and Haemostasis
Familial Hypercholesterolemia
Genetic Causes of Hypercholesterolaemia in the Emirati Population
The scientific aims of the project are to understand the genetic basis of Familial Hypercholesterolaemia (FH) in the Emirati population and estimate the overall prevalence of the disease.
- Trial name
- NCT03597958
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London Diabetes Centre
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Syphilis
Transcriptomic and Next Generation Sequencing Approaches to Infection With Treponema Pallidum
Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade.
- Trial name
- NCT03310424
- Testing
- No active intervention.
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Intellectual Disability, Congenital Abnormalities
Apparently Balanced Chromosomal Translocation/ Next-generation Sequencing/ Intellectual Disability
Apparently balanced chromosomal rearrangement (ABCR) associated with an abnormal phenotype is a rare but problematic event. It occurs in 6% of de novo reciprocal translocations and 9% of de novo inversions.
- Trial name
- ANI (NCT02451761)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hospices Civils de Lyon
Developmental and Epileptic Encephalopathy, Epilepsy in Children
Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing
This study focuses on children with Developmental and Epileptic Encephalopathy (DEE), a severe form of epilepsy that often has a genetic origin.
- Trial name
- EEPILOG (NCT07396883)
- Testing
- Long-read Whole Genome Sequencing (lrWGS)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France