Clinical trials: Next Generation Sequencing
Rare Cancers, Cholangiocarcinoma
TCF-001 TRACK (Target Rare Cancer Knowledge) Study
This open label, non-randomized, multi-center, pragmatic study aims to establish whether patients with rare tumors can benefit from matched molecular therapy as dictated by their next-generation sequencing (NGS) results.
- Conditions
- Rare Cancers, Cholangiocarcinoma, Cancer of Unknown Primary Site
- Trial name
- TRACK (NCT04504604)
- Testing
- FoundationOne CDx and FoundationOne Liquid CDx
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- TargetCancer Foundation
Non-small Cell Lung Cancer
Detection Cell Free DNA in Lung Cancer Patients
third generation of EGFR-TKIs is the newest target therapy for NSCLC. However, we did not known the specific mechanisms for those non-responders and patients grow resistance.Next generation sequencing is current the most…
- Trial name
- NCT02738593
- Where
- 2 sites in China
- Volunteers
- 124 people
- Sponsor
- Sun Yat-sen University
Neoplasms, Cancer
PRediction Of Five Usual Tumors Using Blood Test for Risk Assessment and Early Detection
Liquid biopsy technology based on cell-free nucleic acids and protein characteristics has unique advantages and significant application prospects in cancer early detection.
- Trial name
- PROFUTURE (NCT05874648)
- Testing
- Multi-cancer early detection test
- Where
- China
- Volunteers
- 3,830 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Peripheral Pulmonary Lesions (PPLs)
Advanced Robotic Techniques and Rapid Onsite Evaluation for Minimally Invasive Diagnosis and Next-Generation Sequencing.
ARTEMIS is a multicenter randomized controlled trial. The goal is to understand whether rapid onsite evaluation during robotic assisted bronchoscopy improves the diagnostic performance of the procedure or not.
- Trial name
- ARTEMIS (NCT07685977)
- Testing
- Rapid onsite evaluation
- Where
- 8 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Hematopoietic Stem Cell Transplantation
Metagenomics Next-generation Sequencing Approach to Detect Microbial DNA/RNA Overtime in Individuals Undergoing Hematopoietic Stem Cell Transplant
Infections are a major cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplant (HSCT). The purpose of this study is to evaluate if metagenomic next-generation sequencing (mNGS) can detect…
- Trial name
- NCT06904053
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pulmonary Infection
The Value of mNGS in Diagnosis of Pulmonary Infection
Retrospective analysis of clinical data from 50 hospital-admitted patients with suspected pulmonary infection (as judged by clinical manifestations and imaging findings) was performed on study participants who had collected two…
- Trial name
- NCT06307405
- Testing
- next generation sequencing
- Volunteers
- 50 people
- Sponsor
- Yunfeng Hou
Carcinoma, Non-Small-Cell Lung
Phase II Umbrella Study Directed by Next Generation Sequencing
This phase II, umbrella trial study directed by next generation sequencing (NGS) works in Chinese patients with advanced stage NSCLC who never received any anti-tumor treatment.
- Trial name
- TRUMP (NCT03574402)
- Testing
- Avitinib Maleate, Afatinib, Crizotinib
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Guangdong Association of Clinical Trials
Influenza
Prospective Analysis of Seasonal Influenza - Viral Transmission and Evolution in the City of Basel, Switzerland
Influenza associated illness has a global annual impact with high morbidity and mortality. Transmission mechanisms and rates are under-investigated and overall poorly understood.
- Trial name
- NCT03010007
- Where
- 4 sites in Switzerland
- Volunteers
- 800 people
- Sponsor
- University Hospital, Basel, Switzerland
Muscle-Invasive Bladder Cancer (MIBC), Upper Tract Urothelial Carcinoma
Validation of a Circulating Tumor DNA Blood Test in Muscle-Invasive Bladder and Upper Tract Urothelial Cancer
This prospective observational study evaluates a blood-based circulating tumor DNA (ctDNA) test in patients with muscle-invasive bladder cancer or upper tract urothelial cancer.
- Conditions
- Muscle-Invasive Bladder Cancer (MIBC), Upper Tract Urothelial Carcinoma, Urothelial Carcinoma (UC)
- Trial name
- BLUT-DNA (NCT07756437)
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- AZ Sint-Lucas Gent
Lung Cancer
Feasibility of Targeted Bronchial Washing for Molecular Testing by Next Generation Sequencing in Early-stage Lung Cancer
This is a single center, clinical trial evaluating the relevance of intratumoral washing for detection of generic alteration with Next Generation Sequencing.
- Trial name
- NCT06301295
- Testing
- Ultarthin bronchoscopy with intratumoral washing
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Pusan National University Hospital
Non Small Cell Lung Cancer, Neoepitopes
AImmune - Artificial Intelligence Algorithm for Identification of Immunogenic Neoepitopes of Cancer to Predict and Boost Patient's Response to Immunotherapies.
The goal of the project is to develop and validate A.I.mmune technology. It performs complex analyses of patients' tumor and immune system state using data derived from next-generation sequencing of tumor and healthy tissue to…
- Conditions
- Non Small Cell Lung Cancer, Neoepitopes, Neoantigens, Immunotherapy
- Trial name
- NCT04145232
- Testing
- Collection of biopsy (FFPE), blood (PBMC) and stool
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Ardigen
Female Pelvic Floor Dysfunction
The Study of Genes Localization for Female Pelvic Floor Dysfunction
Female pelvic floor dysfunction (FPD) is due to defects in the pelvic support structures, degradation, damage or dysfunction. The main problem of which is pelvic organ prolapse(POP), urinary incontinence(UI) and genital tract…
- Trial name
- PFD POP UI (NCT02166528)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhiqing, Liang
Coronavirus Infectious Disease 2019 (COVID-19)
COVID-19 in Baselland: Validation of Simple and Accurate Tests for COVID-19 Detection, Monitoring and Tracing (ACCURATE-BL-COVID-19)
This study is to establish an accurate, robust and easily scalable COVID-19 viral nucleic acid analysis platform from, but not limited to, saliva to help enable and support contact tracing in the canton of Baselland/ Switzerland.
- Trial name
- NCT04625257
- Testing
- Saliva based assay: crude RNA extraction, Validation of the NGS method, Validation of the LAMP assays
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastrointestinal Diseases, Colic
Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics
The aim of the study is to elucidate the relationship between postnatal antibiotic administration on development of gut microbiota and possible protective influence of simultaneously administration of probiotic during antibiotic…
- Trial name
- NCT02865564
- Testing
- Lactobacillus reuteri DSM 17938, ampicillin and gentamicin
- Where
- Slovenia
- Volunteers
- 98 people
- Sponsor
- University Medical Centre Ljubljana
Head Neck Cancer, Oral Cancer
Newer Therapeutic Targets in Head and Neck Cancers
Based on the recently identified mutations in HNSCCs, the major pathologic pathways implicated in the tumorigenesis of HNSCC include dysregulation of four processes: 1.
- Trial name
- NCT05382585
- Testing
- Next generation Sequencing
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Banaras Hindu University
Small Cell Lung Cancer
Tempus Small Cell Lung Cancer Observational Study (Sculptor)
The study is a non-interventional evaluation of participants with extensive stage (ES) SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA and CTC biomarker…
- Trial name
- NCT05257551
- Testing
- Observation
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Tempus AI
Vancomycin-Resistant Enterococci, Probiotics
Investigation of the Optimal Cocktailed Probiotics for Decolonization of Vancomycin-resistant Enterococci in Human Gut
Vancomycin-resistant enterococci (VRE) has been a serious public health issue as an opportunistic pathogen and reservoir of antibiotic resistant genes.
- Trial name
- NCT03822819
- Testing
- probiotic cocktail capsules
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Lung Neoplasms, Carcinoma Non-small-cell Lung
Treatment of Multifocal Lung Adenocarcinoma
To gather preliminary safety and outcome data for the multimodality treatment of lung adenocarcinoma in the setting of multifocal BAC.
- Conditions
- Lung Neoplasms, Carcinoma Non-small-cell Lung, Adenocarcinoma
- Trial name
- NCT01946100
- Testing
- Multifocal Lung Adenocarcinoma
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Observational, Prospective
Targeted Next Generation Sequencing for the Efficacy of Trastuzumab Neoadjuvant Chemotherapy in Breast Cancer
To explore the genetic background of patients with HER2 positive breast cancer that benefit from trastuzumab combined with neoadjuvant chemotherapy, identify clinically actionable mutations that associated with trastuzumab…
- Trial name
- NCT03728829
- Testing
- Trastuzumab+TP
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hebei Medical University Fourth Hospital
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Screening Gene Mutations in Myeloid Cancers by Next Generation Sequencing to Improve Treatment Results
Genetic mutations have closely linked to the pathogenesis and prognostication of myeloid cancers. In addition, a number of molecularly targeted agents have been developed in recent years.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myeloproliferative Neoplasm, Aplastic Anemia
- Trial name
- NCT04060485
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital