Clinical trials: Next Generation Sequencing
Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Genomics Study in CML Patients With Ponatinib Treatment
This study will evaluate whether responsiveness and adverse events (AEs) to second-line or later ponatinib treatment are associated with genetic variations as measured by real-time quantitative polymerase chain reaction (qRT-PCR)…
- Trial name
- CAP (NCT06945146)
- Testing
- Ponatinib
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Dong-Wook Kim
Central Nervous System (CNS) Infection, Encephalitis
Establishment of Prevention and Control System of Central Nervous System Infection
Central nervous system (CNS) infection is a common nervous system acute and severe disease, mainly manifested as encephalitis, meningitis and meningoencephalitis, but also manifested as brain abscess and brain granuloma et al.
- Conditions
- Central Nervous System (CNS) Infection, Encephalitis, Meningitis
- Trial name
- NCT04722328
- Testing
- CSF metagenomic next generation sequencing (mNGS)
- Where
- China
- Volunteers
- 715 people
- Sponsor
- Xuanwu Hospital, Beijing
Autism Spectrum Disorder
Precise Objective Automated Assessment System of Autism Spectrum Disorder From an Existing Big Cohort
The project's significance includes a big cohort of Autism spectrum disorder (ASD), originality/novelty (new approaches and technologies including next-generation sequencing, multi-echo functional MRI, metabolomics, microbiomics…
- Trial name
- NCT04875481
- Testing
- Psychiatric diagnosis, ASD diagnosis
- Where
- Taiwan
- Volunteers
- 214 people
- Sponsor
- National Taiwan University Hospital
Familial Lipomatosis, Very Rare Dermatologic Diseases
Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing
The primary purpose of the protocol is to use next generation sequencing to identify pathogenic variants in genes involved in very rare skin diseases.
- Trial name
- DERMA-SEQ (NCT02509650)
- Where
- 2 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Nonunion of Fracture
NGS for Non-unions
The purpose of this study is to investigate the role of genetic testing to look for possible infection as a cause for failure of non-healing fractures.
- Trial name
- NCT03937310
- Testing
- Next-generation sequencing of swabs collected during surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rothman Institute Orthopaedics
Recurrence, Metastasis
Clinical Relevance of NGS Analysis for High-purity CTC From Cancer Patients With Disruptive Gene Mutation(s)
Distant metastasis of cancer remains the major cause of cancer death. One of the evidence is that some rare cells shed from primary tumor exist in the circulation of cancer patients, which has been proven to be related to cancer…
- Conditions
- Recurrence, Metastasis, Death
- Trial name
- NCT03002350
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Malignant Glioma
Molecular Characterization of Gliomas Using a Broad Next Generation Sequencing (NGS)Panel
Gliomas are the most common malignant primary brain tumors with poor prognosis. The genotyping of tumors using NGS platforms enables the identification of genetic alterations that constitute diagnostic, prognostic and predictive…
- Trial name
- NCT05486247
- Volunteers
- 32 people
- Sponsor
- Hellenic Cooperative Oncology Group
Penile Implantation, Infections
Next Generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Implants: Impact of Culture Identification on Outcomes
Randomized prospective study to evaluate next generation sequencing (NGS) and standard-of-care culture for clinically infected penile implants and to compare outcomes with identification of microbes.
- Trial name
- NCT05287438
- Testing
- Next-Generation DNA Sequencing, Standard Culture
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- MicroGenDX
Hepatocellular Carcinoma
Dissection of the Molecular and Immunological Interaction in Patients With HCC of Viral and Non-viral Etiologies
This project will clarify the potential interaction between HBV infection and steatosis, and their impact on genetic alterations and tumor immune microenvironment.
- Trial name
- T4222 (NCT05613621)
- Where
- 4 sites in Taiwan
- Volunteers
- 579 people
- Sponsor
- National Health Research Institutes, Taiwan
Infertility
Next Generation Sequencing Screening for Embryonic Ploidy Status
To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy. All viable blastocysts will be biopsied and cryopreserved for future transfer.
- Trial name
- nexgen (NCT02032264)
- Testing
- Comprehensive Chromosome Screening, Morphologically Best
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Non Small Cell Lung Cancer, Neoepitopes
AImmune - Artificial Intelligence Algorithm for Identification of Immunogenic Neoepitopes of Cancer to Predict and Boost Patient's Response to Immunotherapies.
The goal of the project is to develop and validate A.I.mmune technology. It performs complex analyses of patients' tumor and immune system state using data derived from next-generation sequencing of tumor and healthy tissue to…
- Conditions
- Non Small Cell Lung Cancer, Neoepitopes, Neoantigens, Immunotherapy
- Trial name
- NCT04145232
- Testing
- Collection of biopsy (FFPE), blood (PBMC) and stool
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Ardigen
Vancomycin-Resistant Enterococci, Probiotics
Investigation of the Optimal Cocktailed Probiotics for Decolonization of Vancomycin-resistant Enterococci in Human Gut
Vancomycin-resistant enterococci (VRE) has been a serious public health issue as an opportunistic pathogen and reservoir of antibiotic resistant genes.
- Trial name
- NCT03822819
- Testing
- probiotic cocktail capsules
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Carcinoma, Non-Small-Cell Lung
Phase II Umbrella Study Directed by Next Generation Sequencing
This phase II, umbrella trial study directed by next generation sequencing (NGS) works in Chinese patients with advanced stage NSCLC who never received any anti-tumor treatment.
- Trial name
- TRUMP (NCT03574402)
- Testing
- Avitinib Maleate, Afatinib, Crizotinib
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Guangdong Association of Clinical Trials
Lung Neoplasms
Validation of Molecular Diagnostic Thecnologies for Lung Cancer Patients.
This is a non-interventional multi-center with investigational sites in Chile and Brasil diagnostic study to validate novel diagnostic technologies, such as Next Generation Sequencing (NGS) from both tissue and blood compared to…
- Trial name
- NIRVANA (NCT03220230)
- Where
- 37 sites in Brazil, Chile and 1 more
- Volunteers
- 4,240 people
- Sponsor
- Pfizer
Cancer
Cost of Cancer Diagnosis Using Next-generation Sequencing Targeted Gene Panels in Routine Practice
The aim of this study was to measure the total cost of performing next-generation sequencing (NGS) in clinical practice in France, in both germline and somatic cancer genetics.
- Trial name
- NCT04656717
- Testing
- Measure of the total cost of performing next-generation sequencing (NGS)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Metastatic and/or High Risk Solid Tumor of Children
Use of Specific Genetic Alteration s of Tumoral Cells Identified by the Next Generation Sequencing Techniques (NGS) to Follow Peripheral Samples of Children With Metastatic and/or High Risk Solid Tumor - NGSKids
The search for genetic alterations in primary tumor by NGS techniques followed by the detection of these alterations in circulating tumor DNA and/or CTC/DTC present in peripheral samples (blood, cerebrospinal fluid, bone marrow…
- Trial name
- NGSKids (NCT02546453)
- Testing
- Tumoral specific genetic alterations
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Curie
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics
Ovarian Cancer
MOLecular Characterization and Treatment of THYroid Carcinoma on Struma Ovarii
Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumor, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours, and 5 to 10% of struma ovarii.
- Trial name
- MOLTHYSO (NCT04053114)
- Testing
- DNA and RNA extraction from FFPE or frozen tissue sample
- Where
- France
- Sponsor
- Institut Bergonié
Red Blood Cell Alloimmunization in Pregnancy, HDFN
Prenatal Blood Typing With Next Generation Sequencing (NGS) - an Implementation Study in HDFN (PREFAB)
Determination of Fetal Blood Group by Next-Generation Sequencing - A Clinical Study in Pregnancies with Maternal Alloantibodies Directed Against Fetal Blood Cells (Alloimmunization During Pregnancy) Maternal antibodies can cross…
- Conditions
- Red Blood Cell Alloimmunization in Pregnancy, HDFN, Next Generation Sequencing (NGS)
- Trial name
- PREFAB (NCT07715214)
- Testing
- NGS analysis for fetal red cell blood type in maternal plasma
- Volunteers
- 750 people
- Sponsor
- Karolinska University Hospital
Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma
Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients
This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma.
- Conditions
- Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma, Epithelioid Sarcoma, Solitary Fibrous Tumors
- Trial name
- PIPER (NCT04008238)
- Testing
- Trabectedin
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Institut Bergonié